Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.6 4.6e+02 0.8 0.1 72 108 89 128 62 130 0.72

2 3 1.2e-17 3.4e-15 56.0 0.1 11 109 182 280 172 281 0.90

3 3 3.6 1e+03 -0.3 0.0 81 109 284 312 278 313 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.6	4.6e+02	0.8	0.1	72	108	89	128	62	130	0.72
2	3	1.2e-17	3.4e-15	56.0	0.1	11	109	182	280	172	281	0.90
3	3	3.6	1e+03	-0.3	0.0	81	109	284	312	278	313	0.83

Coding Sequence: ATGGAAGTAGAAAGTTGTGAACTTTTGCCGGATAACACGAGCGTTATTTACGGACACAAAGTTTGCCAGACAAGCGATGCAAAGTGGATGTGCCTTGAGAACATTTACCAAAAGTTCCATCGTCCCAACTTCTATGATATTGGTGGTACTTACATCCAGGATGTGGCTGATTACTGGTTTGTGTATAAAACTGAAAATGTCAATAACATTTATCTTTTACACATCTTTGTCTGCAACCGCCAAGAGAGTATGTTCAGCATATCTATTAGCCGGAGCACAGATATGAAATTAGATAAGAGAAATGGTGCTGTCTACCTTTCCCAATCCCTGAAGGAGTTCAGATTCAAGAAAACAAAAGAAATGTGTCAAAATTATCTTACCACATACAGCTTCAACACCTTTGATATAGACATACTAAAAGACAGAAAACTGTTCATAGCAATTTCCTTTAACAACTCTGATGACAAATGCCTCGATCAGAGTTTGATTCATCAAGTGAAACTGAACCATGATTTTGGTGCTTTGCTTGACGATCCTGTCGGATCAGACTTTGTTATGGAGTCTGCAGATGGGGCCACCTTTAAAGTTCACAAATTAATAATAGGAGCTCATAGTGAAGTGTTTAAAGCTATGCTAAAGGAGGAAACAGCTGAAAGCCAAAATGGCTGCGTGAAATTAGTTGATGTGGGCAAGGAGGACCTTCAGTGTATATTAGAGAGCATTTATACAGGGACCATTAGGGATTTAGAAAATTGCAACTTTTTCAATATGCTGATGCTGGCTGATCGATACAACTTGAAGGGACTGAGAGAGATCTCACAATATGCTCTGGCCCAGCAGCTATCTGTAGAAAATGCCATTGATATATTTATTGTAGCAGACATGTACAATTCTGATGTTCTCAAAATAGCAGCACTTAAATTCATAAAGAAAAATGCATCTTTGATACAGTCAGGCGCATTCAAAGAGATCAACAATGCAGACTTGATGCGTCAGTTGTGTGAATACTTAATTCCTACTTGA
Protein Sequence: MEVESCELLPDNTSVIYGHKVCQTSDAKWMCLENIYQKFHRPNFYDIGGTYIQDVADYWFVYKTENVNNIYLLHIFVCNRQESMFSISISRSTDMKLDKRNGAVYLSQSLKEFRFKKTKEMCQNYLTTYSFNTFDIDILKDRKLFIAISFNNSDDKCLDQSLIHQVKLNHDFGALLDDPVGSDFVMESADGATFKVHKLIIGAHSEVFKAMLKEETAESQNGCVKLVDVGKEDLQCILESIYTGTIRDLENCNFFNMLMLADRYNLKGLREISQYALAQQLSVENAIDIFIVADMYNSDVLKIAALKFIKKNASLIQSGAFKEINNADLMRQLCEYLIPT

Sequence clustering based on sequence similarity using MMseqs2