Basic Information

Gene Symbol
-
Assembly
GCA_949628265.1
Location
OX451263.1:19201721-19205293[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 6.3e-12 1.3e-08 34.4 0.0 12 64 26 76 17 88 0.86
2 3 1.4 2.8e+03 -1.9 0.0 42 67 251 274 226 282 0.60
3 3 5.4 1.1e+04 -3.9 0.0 56 69 426 439 419 441 0.76

Sequence Information

Coding Sequence
ATGAGCAAGAGACTGAGTAAACCATACAATGCATCTGTGATGTGCAAAGTCAAACACATCACACAACCTTTGGGAAAAGATGGTTGGCGTCGAAGAGTTTACCTGAGAACCACTGGCGCGAGTGCAGGTCGCAAGGACATCGTTCTCATCGCCCCTGACGAAACCCTTTTGCGTTCAAGAGTTGAGATTGATCGCTACTGCAAGGAGCACAATTTGACACTGGATCCGGAGGTGTATAGCGTTTCTCAATCAAAAGCTGAACACCttttcaaaaaagaaattgcgGCTCTGATTAGAATTAAAGAAGCAACCAAAAACACTCAAGAGAGTGTTGCTAGGAAAGCTAAAGAAAATGATAAGGCCAACAAAGAGTCGCTTAAAGACAaggtagcagcagcagcatcagcagctcAAATGTCAGTCGCACCAGTTAAGGCCAAGAGGGGCAGGCCGCCAAAAGTTAAGTCTGTCCTCTCTGAGAGATGCAGGAACAAGTCTGGAGACTCTGCTAGCAGCTCTCTCACAAAGAAACGAAAACATTCAGTTTCTCCAGTCAAGGATGCGAAGAAATTGAAGGAATCACCCACTGCATTAACTGGTCGGCAAACAAGGAACTCGCTGGCAACCTCTTTTTCCCCACCAAAGCTGGATAATCCAACTGGGCTGGTCACCCCTGATAGCCTGCCAAAATCTTGGAAGGTGCAGAAAAATGGGGACAGTAACTTGATATTTGTCgagagcggcagcagcagtctGAGCTCCCTTCGACAGCTGAAGATATACGCTGCCAAACACTGCATTCGTGTGGACTTAGAGGAGTTTAAGCACTTCTTTGAAACTCAATCAGACGCGACTGGTAATCATGCAAGCCAAAATGAGACTGCTGAAGCGGACATACCAGAAGGTGCAGACGAAAGTAAGAGTGTTGCTACCTCTGAATCGTTGGAACACATTGAAGATATCAGTGAAGATGAGGAGGACAAAGAAACTGGGGAGCAAGCTGAAGGTTCTGAAGCAAAAAAAGAGGGCGAAGAGGACACTGCATTGGCaaatgcAGAAGAATCTGAGTCCCTGGGGAGTGAATTAGAGGAACTTGCATCAAACATCTTTGAGTCTGACGACTACGACGTGCCAATGGATGACTTTGAAACCAGACTGCAAACTGAAGAGTTtgcaggaaaagaaaaagaaccGGAAGCAGAAGCTAATTCTAAAGAAGTGAAAGAGGAAGAAATTGATCCAGAAATACCAGTTGAAGACATCAAAGTGGTGAACAACAAAGACCTGGACAAGATAGACCCAACCAACTTCAAGTTCTTTGTACTGCCAGAAGATGATGGTGAACTGCCCAGTGACTCAATAACTGCCGCTGATAACCAATGTGAAGAAGAAAGTTCCAACGAGGAGGAGAGCCATGTTCCTGAATCAGCAACAGAATTGGCAGGCGTACAAGGTGAACCAGAAGAAGAGTGGGATCTGTGCTCCCCGTACAACCTGATTTACGAGAGCCTGGGCACAGACCAATGGCGCCTACTTGTTGCCTCGATAATCCAGCCTCACGTGTCGGCACAAGTCGGACAAGTTCTGACTCTCAACTTCCTTGAACGCTGTCCCGACCCAGCATCAGCCCTCCAGCTGTCTGACCCTTTTTCTCTTCCTGAGTGCGAGGTCGACCCAAAGTTTGCGTGGGTGCTGGGCAAATTGCTGAAGCTGGCCAGGTTTCTGACTGAAGGAACAACCGACGAGAAGCTGAAGGAGCTGATTGGATCGTACGGCGTTGCTGTCCTCACTATATTTGGTGAATCAAAGCTGGACATTGTAACAGAAGAGTATGATCTCAAGACATACCTGAGTTGGCGCCGAAACCAGCAAAGTATGGGTCAAGAtgaatag
Protein Sequence
MSKRLSKPYNASVMCKVKHITQPLGKDGWRRRVYLRTTGASAGRKDIVLIAPDETLLRSRVEIDRYCKEHNLTLDPEVYSVSQSKAEHLFKKEIAALIRIKEATKNTQESVARKAKENDKANKESLKDKVAAAASAAQMSVAPVKAKRGRPPKVKSVLSERCRNKSGDSASSSLTKKRKHSVSPVKDAKKLKESPTALTGRQTRNSLATSFSPPKLDNPTGLVTPDSLPKSWKVQKNGDSNLIFVESGSSSLSSLRQLKIYAAKHCIRVDLEEFKHFFETQSDATGNHASQNETAEADIPEGADESKSVATSESLEHIEDISEDEEDKETGEQAEGSEAKKEGEEDTALANAEESESLGSELEELASNIFESDDYDVPMDDFETRLQTEEFAGKEKEPEAEANSKEVKEEEIDPEIPVEDIKVVNNKDLDKIDPTNFKFFVLPEDDGELPSDSITAADNQCEEESSNEEESHVPESATELAGVQGEPEEEWDLCSPYNLIYESLGTDQWRLLVASIIQPHVSAQVGQVLTLNFLERCPDPASALQLSDPFSLPECEVDPKFAWVLGKLLKLARFLTEGTTDEKLKELIGSYGVAVLTIFGESKLDIVTEEYDLKTYLSWRRNQQSMGQDE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-