Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 1.9e-15 6.7e-13 49.5 0.3 3 108 62 165 60 167 0.94

2 4 8.3 3e+03 -0.9 0.0 78 102 167 191 164 198 0.66

3 4 2.7e-08 9.8e-06 26.4 0.4 39 108 228 296 225 298 0.90

4 4 9.2 3.3e+03 -1.0 0.0 78 103 298 323 296 330 0.70

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	1.9e-15	6.7e-13	49.5	0.3	3	108	62	165	60	167	0.94
2	4	8.3	3e+03	-0.9	0.0	78	102	167	191	164	198	0.66
3	4	2.7e-08	9.8e-06	26.4	0.4	39	108	228	296	225	298	0.90
4	4	9.2	3.3e+03	-1.0	0.0	78	103	298	323	296	330	0.70

Coding Sequence: ATGTCAGCAAAAGATTTGACAGTCTTATTGAAAATTGATTGTGAAGAGACgaattttaaaaaagaaaatataattTGCGCAGAAGATTGGTGTACCTGGATAACTATTGGTACTACCACCAACAATTCTTTTGGGGTCGATTTAGAAGTTACACTGTCGAAAGATCAATCAGTTATTAACACGAAACTTTACAATGATGAGACATTTACTGAATTCACATTGAGCGGAGAAGATGGTAGTGTGGTGGTGCACAAAGCGCACCTGGCTGCTCACAGTGACCCATTAATGGCAATGCTTCATCAACCGATGGTTGAGAAAGGACAAAATCGTATTCAGCTGAAAGGAGTCACTGTTGCAACCTTAAAGCACTTGAAGGAGTACATGTATTTAAGCACTTTGCCTAGCAATAACGAAGACTTGCGCGCACTACTGCAGTTTGCAACgcagtattttatttacagtcTGGAGGCAGAATGCTCGATGAAGCTGCTCCAGACAATAACAGCTGAAAACTTGGACAGCCTCATTGACTTTTGTACAGAGTATAAAATTCATAACTTACTAAGCAGCATTCATAAGACAACCCCTGATACTGTTTTAGCTGCAGCTGGTGCCATAAGGGTAAAAAAACGGTTAGATTCCGTAGCCGAAGTTGTAGGTAAAAATAAAGACACCAAGAAAAAAATGCTTCATCAACCGATGGTTGAGAAAGGACAAAATCGTATTCAGCTGAAAGGAGTCACTGTTGCAACCTTAAAGCACTTGAAGGAGTACATGTATTTAAGCACTTTGCCTAGCAATAACGAAGACTTGCGCGCACTACTGCAGTTTGCAACgcagtattttatttacagtcTGGAGGCAGAATGCTCGATGAAGCTGCTCCAGACAATAACAGCTGAAAACTTGGACAGCCTCATTGACTTTTGTACAGAGTATAAAATTCATAACTTACTAAGCAGCATTCATAAGACAACCCCTGATACTGTTTTAGCTGCAGCTGGTGCCATAAGGGTAAAAAAACGGTTAGATTCCGTAGCCGAAGTTGTAGGTAAAAATAAAGACACcaagaaaaaaagaaaggaatAA
Protein Sequence: MSAKDLTVLLKIDCEETNFKKENIICAEDWCTWITIGTTTNNSFGVDLEVTLSKDQSVINTKLYNDETFTEFTLSGEDGSVVVHKAHLAAHSDPLMAMLHQPMVEKGQNRIQLKGVTVATLKHLKEYMYLSTLPSNNEDLRALLQFATQYFIYSLEAECSMKLLQTITAENLDSLIDFCTEYKIHNLLSSIHKTTPDTVLAAAGAIRVKKRLDSVAEVVGKNKDTKKKMLHQPMVEKGQNRIQLKGVTVATLKHLKEYMYLSTLPSNNEDLRALLQFATQYFIYSLEAECSMKLLQTITAENLDSLIDFCTEYKIHNLLSSIHKTTPDTVLAAAGAIRVKKRLDSVAEVVGKNKDTKKKRKE

Sequence clustering based on sequence similarity using MMseqs2