Basic Information

Gene Symbol
-
Assembly
GCA_036417725.1
Location
CM071139.1:8989763-9002283[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 0.00012 0.0078 17.1 0.1 3 23 131 151 130 151 0.97
2 19 1e-06 7.1e-05 23.6 1.2 1 23 157 179 157 179 0.99
3 19 6.5e-06 0.00044 21.1 2.7 1 23 185 207 185 207 0.99
4 19 4.3e-06 0.00029 21.6 2.6 1 23 222 244 222 244 0.98
5 19 0.00023 0.015 16.2 0.3 1 23 259 281 259 281 0.98
6 19 5.9e-05 0.0041 18.0 3.1 1 23 296 318 296 318 0.98
7 19 4.1e-07 2.8e-05 24.8 1.5 1 23 333 355 333 355 0.99
8 19 0.00018 0.013 16.5 2.8 1 23 361 383 361 383 0.98
9 19 0.00041 0.028 15.4 0.1 1 23 390 412 390 412 0.99
10 19 1.3e-05 0.00088 20.1 2.1 1 23 418 440 418 440 0.99
11 19 0.042 2.9 9.1 1.8 1 23 447 469 447 469 0.98
12 19 7e-07 4.8e-05 24.1 2.3 1 23 475 497 475 497 0.99
13 19 0.049 3.3 8.9 1.8 1 23 504 526 504 526 0.98
14 19 2.9e-06 0.00019 22.2 1.5 1 23 532 554 532 554 0.99
15 19 0.00054 0.037 15.0 0.7 1 23 561 583 561 583 0.99
16 19 2.8e-06 0.00019 22.2 1.8 1 23 589 611 589 611 0.98
17 19 0.0023 0.16 13.0 0.3 1 20 617 636 617 639 0.93
18 19 4.5e-05 0.003 18.4 1.4 2 23 646 667 645 667 0.96
19 19 3.5e-06 0.00024 21.9 1.3 1 23 673 696 673 696 0.97

Sequence Information

Coding Sequence
ATGTTCGAACAACAGATCAAGGCTGAGCCTATGAGcTTTTACACCTCCCATCCACATGTACACTCCGGTCCCCCAACAATAGTCCGTTCGGATTCAAACCAAGGGATCATCAGCATGCATCACCAACATCACCAAGAGGACTCGAAGGACAGCCTTATAGTTCAACAACAAGTACAACACCAACAGGACCTTATGGAACAACACCAACAACAGGAATTGCAACAACAGGATGACGAGCTGAGCTTTAAAGGTATGGATGATGAAGGCGTTGATATGGATATGGATGGCCGACAATGCTCCCAGGGCATGGGTGTGGACCTGGGTTCAGTACAAACTAAAATGGAAGTCTCAAACGGGGGTCAGTCGGCACCACGGTCTAAACCACAGGCTTGTAAAGTCTGTGGCAAAGTACTATCGTCCGCGTCATCATATTACGTCCACATGAAACTTCATTCAGGAAATAAGCCCTTTCAATGCACGGTATGCGACGCGGCGTTTTGTCGCAAGCCGTACTTGGAAGTGCACATGCGCACGCACACGGGGGAGCGCCCCTTCCAATGCGATCTCTGCCTGAAGCGATTCACACAAAAGTCCAGTCTCAACACGCACAAACGCGTCCACACAGATGAGCACATGCGCGCGTTGATGGTGAAGGACCGGCCCTACAAGTGTGAGCTCTGTCAGATGCGGTTCACGCAGAGCTCCAGCCTCAACAGACACAAGAAAATACACACGGAGGAACACAGACGCGCGCTGCTGGCTAAGGAACGACCCTACCAGTGCGGCATCTGCCTAGTGAGATTCACCCAGAAATCGAGTTTGGGCCGGCACGGGAAAATACACACCGAGGAGCACAGACGAGCCCTGTTAGAGAAAGTGCGGCCGTACCAGTGCCACATCTGTTTTATGCGCTTCACTCAGAAGTCCAGCCTGGGACGACATGGGAAAATACATACCGAGGAGCACATCCAATCGCTGATCAACAAAGTGCGCCCCTATCAATGTGACATCTGTGACAAGCGGTTCACGCAGAAGTCCAGCCTTGGCACTCATAAACGTATACACACCGGGGAGCGGCCGTTCCAGTGCACCGTCTGCCTCAAGTCCTTCACGCAGAAGTGCGCGCTCAATTTGCACGAAAAGATACATACGGTGCAAGGGCGCCCTTACCGGTGCGGGCTCTGCCCCGCGGCCTTCGCACGCCGCCCCTACCTGGACTCTCACGTGCGCACGCATACAGGCGAGCGGCCCTATCAGTGCGACGCGTGTCTCAAGCGCTTCACACAGAAGTCCAGCCTCAATATACATAAGAGGACGCACACAGTCCAGGGCAGACCGTTCCAGTGCCTGTCGTGCCCCGCCGCCTTCACCTGCAAGCAATACTTGGAGATTCACACGCGCACGCACACCGGCGAGCGACCCTATCAGTGCGACATCTGTCTCAAGCGGTTCACACAGAAATCCAGTCTCAACATACACAAGCGGACGCACTCAGTGCAGGGGCGGCCCTTCCAGTGCCTGCAGTGCCCGGCCGCCTTCACCTGCAAGCAGTACCTGGAGATCCACAACCGCACGCACACCGGCGAGCGACCCTACCAGTGTGACGTCTGCCTCAAGAGATTCGCGCAAAAATCTACACTCAACATACACAAAAGAACGCACACAGTGCAAGGTCGCCCGTACCAATGCATGGAGTGTCCTGCGGCGTTCACATGCAAGCCGTACCTGGAGATACACATGCGCACGCACACCGGCGAACGTCCGTTCGAGTGCGATGTCTGTTACAAACGCTTCTCGCAGAAATCCACGCTCAACATTCACAAACGCATTCATACCGGGGAACGTCCATACGCATGTGATATTTGTCAGAAACGCTTTGCTGTGAAGAGCTACGTTACAGCTCATAGATGGTCGCACGTGGCGGACAAGCCGCTGAACTGCGACCGGTGCTCGATGACGTTCACGTCCAAGTCGCAGTTCGCGCTGCACATCCGCACGCACTCCGCCGGCTCCTGCTACGAGTGCAGCGTCTGCGGACGGAGCTTCGTCAGGGACAGCTATTTAATAAGACACCACAACCGCGTGCACCGTGAGAACCACAGTAACATGTCAGCCAACAGCATCGGCATCAACAGCATCGCCACCAACACTAACAACTCCACCACCAACTACGACTCGCCCGGCGTCTGTGACTTAAGCTTTGTGCCAATGGTGAATCGATATATGACCTCGCAAGGAACTCAGGTCTCGATGCAAGACACGCAGAGCAAAATGTCGGCGATGTCACCGCAATCTATTGCGTCTATTTCATCGCCGCCGCCCTCACACACCCCTACCCCGCAACCCCAGATGTCAGGTCAGATGCATCTCGCAGACTGA
Protein Sequence
MFEQQIKAEPMSFYTSHPHVHSGPPTIVRSDSNQGIISMHHQHHQEDSKDSLIVQQQVQHQQDLMEQHQQQELQQQDDELSFKGMDDEGVDMDMDGRQCSQGMGVDLGSVQTKMEVSNGGQSAPRSKPQACKVCGKVLSSASSYYVHMKLHSGNKPFQCTVCDAAFCRKPYLEVHMRTHTGERPFQCDLCLKRFTQKSSLNTHKRVHTDEHMRALMVKDRPYKCELCQMRFTQSSSLNRHKKIHTEEHRRALLAKERPYQCGICLVRFTQKSSLGRHGKIHTEEHRRALLEKVRPYQCHICFMRFTQKSSLGRHGKIHTEEHIQSLINKVRPYQCDICDKRFTQKSSLGTHKRIHTGERPFQCTVCLKSFTQKCALNLHEKIHTVQGRPYRCGLCPAAFARRPYLDSHVRTHTGERPYQCDACLKRFTQKSSLNIHKRTHTVQGRPFQCLSCPAAFTCKQYLEIHTRTHTGERPYQCDICLKRFTQKSSLNIHKRTHSVQGRPFQCLQCPAAFTCKQYLEIHNRTHTGERPYQCDVCLKRFAQKSTLNIHKRTHTVQGRPYQCMECPAAFTCKPYLEIHMRTHTGERPFECDVCYKRFSQKSTLNIHKRIHTGERPYACDICQKRFAVKSYVTAHRWSHVADKPLNCDRCSMTFTSKSQFALHIRTHSAGSCYECSVCGRSFVRDSYLIRHHNRVHRENHSNMSANSIGINSIATNTNNSTTNYDSPGVCDLSFVPMVNRYMTSQGTQVSMQDTQSKMSAMSPQSIASISSPPPSHTPTPQPQMSGQMHLAD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00010401;
90% Identity
iTF_00150865;
80% Identity
-