Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 6.2e-11 5.1e-08 32.5 0.2 12 68 37 91 32 99 0.83

2 2 0.82 6.7e+02 0.1 0.0 14 27 101 113 95 123 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	6.2e-11	5.1e-08	32.5	0.2	12	68	37	91	32	99	0.83
2	2	0.82	6.7e+02	0.1	0.0	14	27	101	113	95	123	0.83

Coding Sequence: ATGGCCAACATGATCAATAGTGGAACACGACCAGCGTTACCTGACCAGCCTAGGGATCGTCGTAGAAAAAAGATCGATGCAACAAGTTATTTATATAAAGTTCCGTTCGCCTTCGGCTGGAATAGAGAAATAGTCCTGAGAAATACATATCCAAGAAAAAAAAAAAAGGGCGATGTGTATTATTACTCGCCAGAAAATGTAAAATTTAGGTCGATAAAAGAAATTTTCAGAGCATTGCCAGAAAACGGAATATTGAAAACCAAACATTTTTTAATGGCACCTATTCCAACGGAAGTAAATGATTATAGGACAGAATTTATCCGCAAGGCCGGTACAAAACCAAAAGAATATATGGAATTTAATAATAAGCGTACACGGAATTTAGCCACTGAAGAAGAAGCTGCTGTCAATGGTATGGGTGTCAAGGAAGAAAATATTGCACCATCTACATCACAGCTATGTTGTCACTGTAACAATTACCACAATTAA
Protein Sequence: MANMINSGTRPALPDQPRDRRRKKIDATSYLYKVPFAFGWNREIVLRNTYPRKKKKGDVYYYSPENVKFRSIKEIFRALPENGILKTKHFLMAPIPTEVNDYRTEFIRKAGTKPKEYMEFNNKRTRNLATEEEAAVNGMGVKEENIAPSTSQLCCHCNNYHN

Sequence clustering based on sequence similarity using MMseqs2