Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 5.7e-15 4.7e-12 45.5 0.1 11 72 27 82 21 85 0.90

2 2 1.2e-11 9.9e-09 34.8 0.0 22 72 90 134 86 138 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	5.7e-15	4.7e-12	45.5	0.1	11	72	27	82	21	85	0.90
2	2	1.2e-11	9.9e-09	34.8	0.0	22	72	90	134	86	138	0.87

Coding Sequence: ATGGCCTATTTGAATTGGGATCCATTGGCTATAGAAAGGCTGTATAAAATTCTTCTTTATCCCAAGTTAAATAGGCCATTTGATTTTGGCTGGAGACGAGAAGTGGTGCATAGGGCCAATGGAAATGCAATTGATATCTATTACTTTGCGCCAGAAAACATAAAGCTACGATCAAAACCGGAAGTCAATGAATACTTAAAGCCAAAAACCCGATTGAAAATACATCATTTCACGTTTGCAAGAAAACCACTAGGTTTAGTGGTGCATAGGGCCAATGGAAATGCAATTGATATCTATTACTTTGCGCCAGAAAACAAAAAGCTACGATCAAAACCGGAAGTCAATGAATACTTAAAGCCAAAAACCCGATTGAAAATACATAATTTCACGTTTGCAAGAAAACCACTAGGTTTAGACAATTCCAAGGAAATATGCAGAAACGCTTATTCCACTGAAAGAGCTGAAAATAATCGTGGTGGAAACGGTATAAATAATGTAGAAAACCAAATTGTACAGTTAACTATTGAAGAAGATAATACACATAATGTACAATCCTGTTCTAAGAGTACTGGCAAAATTGTAGAATCAGATAAAGTTGTTTATCTGAAACAAATATGCGTTTAG
Protein Sequence: MAYLNWDPLAIERLYKILLYPKLNRPFDFGWRREVVHRANGNAIDIYYFAPENIKLRSKPEVNEYLKPKTRLKIHHFTFARKPLGLVVHRANGNAIDIYYFAPENKKLRSKPEVNEYLKPKTRLKIHNFTFARKPLGLDNSKEICRNAYSTERAENNRGGNGINNVENQIVQLTIEEDNTHNVQSCSKSTGKIVESDKVVYLKQICV

Sequence clustering based on sequence similarity using MMseqs2