Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.9e-16 1.5e-13 50.2 0.5 10 72 16 72 11 76 0.93

2 2 1.9e-16 1.5e-13 50.2 0.5 10 72 249 305 244 309 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.9e-16	1.5e-13	50.2	0.5	10	72	16	72	11	76	0.93
2	2	1.9e-16	1.5e-13	50.2	0.5	10	72	249	305	244	309	0.93

Coding Sequence: ATGGATCCAAAGTCCAAAATGCCAATGGATCCAATTTTCAACAGGCCGTTTGAATATGGTTGGAAAAGAGAGGTGGTATATAGGACCAATGGAAATGCAATTGATATATATTACCGTACACCAGATAAAAAGAAACTAAGATCGAAACCGGAAGTACGTGAATATTTAAAGCAAAGAACGCGATTGAAAATAGAGAATTTCACGTTTAAAAGAAAAGCCCTAGGTTTAGACAATTCCAAGGAAATATGCAGAAACGCTTATTCAACTGAAAGAGCTGAAAATAATCGTGGTGGAAACGAAAAGCCCAATAATGACCGATCCTCTTCTACGAGTACTGGCAAAACTGTAGAATCAGATAAAGGTAGATTGACTGAAACAAATATGCGTTTAGATATTAACGGTCGGCGATTTCAGTTTAAAAAGAGATCAAATAAAGAAAGCCAAGCTAAACTAGCCTTTATTAATGATATAATATATGAATCGGACAACACCACTCCACTATATTCCCCTTTTCTTCTCAAAAGAGACTTCTCCTTTCATTTCGACATTATTCTATCGCACTGGAAGTCGTCATCGGTTTACCGCCCGTCTTCATCAAGCGAAAATCTCGGGAGGTCGAACGATCGTTTTATATTTGAAGAACTAACATTATCATCTACTCCTACGAATCACCGTACATTTGGCTGTAAAACAATTTCAATGGATCCAAAGTCCAAAATGCCAATGGATCCAATTTTCAACAGGCCATTTGAATATGGTTGGAAAAGAGAGGTGGTATATAGGACCAATGGAAATGCAATTGATATATATTACCGTACACCAGATAAAAAGAAACTAAGATCGAAACCGGAAGTACGTGAATATTTAAAGCAAAGAACGCGATTGAAAATAGAGAATTTCACGTTTAAAAGAAAAGCCCTAGGTTTAGACAATTCCAAGGAAATATGCAGAAACGCTTATTCGACTGAAAGAGCTGAAAATAATCGTGGTGGAAACGGTATAAATAATGAAAATTATTTTTAG
Protein Sequence: MDPKSKMPMDPIFNRPFEYGWKREVVYRTNGNAIDIYYRTPDKKKLRSKPEVREYLKQRTRLKIENFTFKRKALGLDNSKEICRNAYSTERAENNRGGNEKPNNDRSSSTSTGKTVESDKGRLTETNMRLDINGRRFQFKKRSNKESQAKLAFINDIIYESDNTTPLYSPFLLKRDFSFHFDIILSHWKSSSVYRPSSSSENLGRSNDRFIFEELTLSSTPTNHRTFGCKTISMDPKSKMPMDPIFNRPFEYGWKREVVYRTNGNAIDIYYRTPDKKKLRSKPEVREYLKQRTRLKIENFTFKRKALGLDNSKEICRNAYSTERAENNRGGNGINNENYF

Sequence clustering based on sequence similarity using MMseqs2