Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3.2e-23 7.3e-20 69.8 0.0 2 72 5 70 4 75 0.94

2 2 0.004 9.2 5.3 0.0 29 73 96 149 76 153 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3.2e-23	7.3e-20	69.8	0.0	2	72	5	70	4	75	0.94
2	2	0.004	9.2	5.3	0.0	29	73	96	149	76	153	0.80

Coding Sequence: ATGTCGGCCCTTGAGAAGAAAAGATACGATTGCACCGCCCTTCCAAAGGGCTGGCAGAGGGAAGAGATCACGAGGAAGTCGGGACTCTCCGCCGGGAAAGTCGACGTCTGCTACTACAGCCCCGAGGGTCAGAAATTTGAAAGCAAGCCGCAGCTCGTCCGCGCAATAAGCGACACCGTCGACCTGACGGCGTTCGACTTCTCGACCGGCAAGTGCAATAACAGCCTCCTGGTGCGGAGGCACAAAAAACCAAGAGCTAACCAGTTTGACTACAGCAGCCGAGGGATGCGGAATGATGCCTCCCTGGTGCCTCCGATTAGACAGACAGCGTCCATATTTAAGCAACCAGTGACTCTGTACCGCACCCAGGAGGGTAAGACCAAATCGGAGTTTGGAAAACATGGAAACCAAGAAAAGCCCAAGCAGttgttctgggaGAAACGACTCGAAGGGCTGAGGGCGAGTGACATAGATGGTTCAGAACTCAAAGGAATGGAACTACCAAGGAATTTGAAATCAGTCGGACCAAATGTCAATGACGAGACGCTACTACAGTCCATGGCCACTGCTTTACACGTCCTCGGTCAGCCTATAACAGGCCAGCTGGGAGCGAAAGCCTCCCTTGAGAAAAATCCAGGCGTTTACCTCAACCCTGAGCAACCACTTGTTCAGGCCGTTTCAATCACTGAAGAAGATATTAAAAGACAGGAAGAGCGAGTCAACCTTGCCCGGAAGAGGCTTGAAGATGCTATGAAAGAGCTGGAAGGCTAA
Protein Sequence: MSALEKKRYDCTALPKGWQREEITRKSGLSAGKVDVCYYSPEGQKFESKPQLVRAISDTVDLTAFDFSTGKCNNSLLVRRHKKPRANQFDYSSRGMRNDASLVPPIRQTASIFKQPVTLYRTQEGKTKSEFGKHGNQEKPKQLFWEKRLEGLRASDIDGSELKGMELPRNLKSVGPNVNDETLLQSMATALHVLGQPITGQLGAKASLEKNPGVYLNPEQPLVQAVSITEEDIKRQEERVNLARKRLEDAMKELEG

Sequence clustering based on sequence similarity using MMseqs2