Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 4.5e-38 5.4e-35 119.9 0.0 2 83 72 152 71 156 0.96

2 3 3.2 3.9e+03 -1.4 0.1 30 49 240 258 230 273 0.76

3 3 3.5 4.1e+03 -1.5 0.4 38 77 309 325 293 334 0.49

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	4.5e-38	5.4e-35	119.9	0.0	2	83	72	152	71	156	0.96
2	3	3.2	3.9e+03	-1.4	0.1	30	49	240	258	230	273	0.76
3	3	3.5	4.1e+03	-1.5	0.4	38	77	309	325	293	334	0.49

Coding Sequence: atggcgcctgtTTTCCAGTCCAGCTTTTCCATACGCGCCTTGTtgtccaacaacaacagcagcagcagcagcacacaaCTGGAGAGTAATACAAACGCCGCCGAATATTATATAAATGCACCAGCGGAGAGTCCCAGCGAATCGAATTCTTCAGAGGATGCCTCCTCAGACGAATGCAACACTGTGCAGAGCAATAAGCATAAAAGTGAAACCAAGCCGGCTTATACCTACAGTGCGCTCATTGTAATGGCCATACGCAGCAGTCCGGAGAAACGTCTGACACTGAGCGGCATTTGTAAATGGATAGCCGATAATTTTGCCTATTATCAGAATCACAAAAGCGTTTGGCAAAATTCCATACGTCATAATTTGAGCTTGAATCCTTGTTTTGTGCGTGTGCCACGCGCACTAGACGATCCCGGACGTGGTCATTATTGGGCGCTGGATCCATTTGCGGAGGACTTGACAATTGGTGAGACCACAGGACGTTTGCGGCGCAGCAATACAGCGCTGCTATGTCGCAATCTGGGCACAGCAACGGCCGCACTACGTACAAAGGCTGCACTGCAGCAGTATGGCAAAAGTTTTGTGCATCCTTATCCTTATCAACAGCTAAACAGCTGTAGCTCTAACATGGCATTGTATGCGGCGCAGCTTATTAAACCGAATGCAGCCTATTTTCCCATCTCAGATGAACTACGCGCCGCACAACAGCACAGAATCAtaatgcaacagcaacaacaacaacaacaacaacagcaggctTGGGATAACAACCGACAGCTTGGGACAACAACAAATCTTAGCGAAACTTCAGCACAGTTGCAAGCGGCAGCACATcgataccaacaacaacaacagcaacaagctgCACTGCTATCGCAGCAGTTCCATCGTgcttgcaacagcaacaacaacaacaattactacCAACGACAAGCAACGCAGcaacaaacccaacaacaacacaattattatctacaacaacaacagcaatcgTATGGAGCAGCACTGCCTTCAGTTTATTCCGGCAAGTGGATGCGACAACCTCTTGGACATGCAAGTGGAATTTGGCGTTAG
Protein Sequence: MAPVFQSSFSIRALLSNNNSSSSSTQLESNTNAAEYYINAPAESPSESNSSEDASSDECNTVQSNKHKSETKPAYTYSALIVMAIRSSPEKRLTLSGICKWIADNFAYYQNHKSVWQNSIRHNLSLNPCFVRVPRALDDPGRGHYWALDPFAEDLTIGETTGRLRRSNTALLCRNLGTATAALRTKAALQQYGKSFVHPYPYQQLNSCSSNMALYAAQLIKPNAAYFPISDELRAAQQHRIIMQQQQQQQQQQQAWDNNRQLGTTTNLSETSAQLQAAAHRYQQQQQQQAALLSQQFHRACNSNNNNNYYQRQATQQQTQQQHNYYLQQQQQSYGAALPSVYSGKWMRQPLGHASGIWR

Sequence clustering based on sequence similarity using MMseqs2