Ccos000069.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Chymomyza costata
Gene Symbol
KLHL5
Assembly
GCA_018150985.1
Location
JAECWU010000803.1:5675483-5677185[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 6.5e-30 9.1e-28 96.7 0.0 4 108 28 132 25 134 0.95

Sequence Information

Coding Sequence
ATGTCTACGGAAAACCAAGAAAACTGCAAATCTTGCAATAATAATCACCATGCCGACATGGTTCTAAAAAAACTAAAAGGGCATCTGGACAGAGAACAACTGTGCGATGTGGTTCTGATCTCGGGCTTAGACGGAAAACGTTTGCCAGCCCATCGCTTGGTGTTGTCCGCCAACAGTGAATTCTTCTCGGCAATGTTCACCAATCCAATGCGGGAAGCCAACGACAATGAGGTGACTCTTGGCGATGTAAACAACGAAGTTCTACAAATTCTGATCAACTACTGCTACACGGGAAACCTTGAAGTGCATGACGAGAATGTTGAGCTACTCATAACCACCGCCAATAGGTGGCAAATGGATTCTGCAGTCACGGCCTGCGGGAATTTTATGGCACGCAAAATGGATTCATCGAACTGCCTGGGCATTGCCTTAATTGCAGAGCAGCTCAACTGCACCACTTTGATGGAACTCACTGTGGACTATACCAGTAAGCATTTTGAGGATGTCAGCCAGAGTCAAGAGTTCTTACAATTGAGTGCCGATCACTTGGGCAAGCTGCTGTCCAGTGATGATCTCCAAGTACCCTCCGAGGAGAATGTGTTTCAGAGTCTAATGGCTTGGGTGCAACATGATAAGTCCTCACGCCAACAGCACATACCAATACTGATGGCAAAGGTGAGGCTTCCACTAATGACACTGTCGTTTATTGAGGATCATGTGGAGAGCGTGTGCAGTGCCAATGAGTGCCACAGTCAACTTGTGGAAGCATATAAGTGTCATGCCATGCCCGAGCGACTATTATCGCTTGCCCGGAGAAAGACAACGGCAAGAAATGATTGTTTGCTTGCAATTGGAAAAAGGGAGCAAGATCTTGTGATTGAGAGCTACTGTCCCACTAAGAAGCAATGGGCGCTCGTAAACAAACTTAAATTACAACGTGATGAATATGGTGCAGCATTTATTGAGAATAAACTGATATTGGTTGGTGGACGTAATGCAGGAGGTGATTTAAACACGGTGTTGAGCTTAGATTTAAAGAGCATGACCTGGACCCAACTCCAACCAATGAGTACACCAAGGAAGAGTATGGGCGTGGCAGTGCTAATGGGATTACTCTATGTGGTGGGCGGTTGGAATAATTCACCTTTGAATACAGTAGAGCGATGGAATCCTGCAACAGGTGATTGGAACAGTGTGGCACCCATGCCAACCGCAAGATATATTATCGGTGTGGCAGTTCTGAACGATTGTTTATATGCTATTGGTGGATTTAATAAAGTTAATAGCCGTTTGAGCTGCGTGGAAAGGTATGATCCATGCACAAACGAGTGGAGTCGTTTATCGCCCATGAACGAAGCTCGTGCATGGTGTGGAGTGGTACAAGCAAATGGGCTTCTTTATGCAATAGGCGACTATTTTGATAATTTAAATTCTGTTGAGTGTTACAATCCAACTATTGATGAATGGACAAAGGTTTGCTCGCTGACACACGGCCGGTGGGGACATGGCTGTGCTCTGCTTGCTAATCGTATTGTTGTAGCCGGCGGCGCAAAGTCTAATGGTACTGTCGAGGAATACGATCCAGTGCACGATGTCTGGAACAAACTTGCGTCGTTAAACAATCGCATGCATCCAACTTCCCTTTTCATCATACCCAATGATGTCACTAAGCCAACAGAAAATCCGTAA
Protein Sequence
MSTENQENCKSCNNNHHADMVLKKLKGHLDREQLCDVVLISGLDGKRLPAHRLVLSANSEFFSAMFTNPMREANDNEVTLGDVNNEVLQILINYCYTGNLEVHDENVELLITTANRWQMDSAVTACGNFMARKMDSSNCLGIALIAEQLNCTTLMELTVDYTSKHFEDVSQSQEFLQLSADHLGKLLSSDDLQVPSEENVFQSLMAWVQHDKSSRQQHIPILMAKVRLPLMTLSFIEDHVESVCSANECHSQLVEAYKCHAMPERLLSLARRKTTARNDCLLAIGKREQDLVIESYCPTKKQWALVNKLKLQRDEYGAAFIENKLILVGGRNAGGDLNTVLSLDLKSMTWTQLQPMSTPRKSMGVAVLMGLLYVVGGWNNSPLNTVERWNPATGDWNSVAPMPTARYIIGVAVLNDCLYAIGGFNKVNSRLSCVERYDPCTNEWSRLSPMNEARAWCGVVQANGLLYAIGDYFDNLNSVECYNPTIDEWTKVCSLTHGRWGHGCALLANRIVVAGGAKSNGTVEEYDPVHDVWNKLASLNNRMHPTSLFIIPNDVTKPTENP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00337636; iTF_00337623; iTF_00337638; iTF_00337624; iTF_00338458; iTF_00338440; iTF_00338459; iTF_00338444; iTF_00338448; iTF_00338445; iTF_00338455; iTF_00338468; iTF_00338463; iTF_00338453; iTF_00337632;
90% Identity
iTF_00337636; iTF_00337624; iTF_00337638; iTF_00337623;
80% Identity
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