Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 2.3e-06 0.03 15.9 0.1 20 52 3 35 1 36 0.95

2 9 0.036 4.6e+02 2.5 0.2 23 43 34 54 32 62 0.78

3 9 0.19 2.5e+03 0.1 0.0 26 52 65 91 56 93 0.86

4 9 0.42 5.5e+03 -0.9 0.1 21 30 88 97 77 101 0.87

5 9 0.0041 54 5.5 0.0 22 50 117 145 109 147 0.85

6 9 1.2e-05 0.16 13.6 0.1 21 52 144 175 141 176 0.91

7 9 0.018 2.3e+02 3.5 0.0 22 47 173 198 170 202 0.87

8 9 0.12 1.6e+03 0.8 0.0 26 51 205 230 199 233 0.84

9 9 0.52 6.8e+03 -1.2 0.1 22 30 229 237 226 239 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	2.3e-06	0.03	15.9	0.1	20	52	3	35	1	36	0.95
2	9	0.036	4.6e+02	2.5	0.2	23	43	34	54	32	62	0.78
3	9	0.19	2.5e+03	0.1	0.0	26	52	65	91	56	93	0.86
4	9	0.42	5.5e+03	-0.9	0.1	21	30	88	97	77	101	0.87
5	9	0.0041	54	5.5	0.0	22	50	117	145	109	147	0.85
6	9	1.2e-05	0.16	13.6	0.1	21	52	144	175	141	176	0.91
7	9	0.018	2.3e+02	3.5	0.0	22	47	173	198	170	202	0.87
8	9	0.12	1.6e+03	0.8	0.0	26	51	205	230	199	233	0.84
9	9	0.52	6.8e+03	-1.2	0.1	22	30	229	237	226	239	0.87

Coding Sequence: ATGAACACCAGTGAAAAACCATATAAGTGTGACTTATGCAGTTCAAAATTCAGTGATAAAAGTAATTTGAAAAGACATGTTAGGTTGCAACATGGCTTCAAACCATACAAGTGTAAAATTTGTTATAAGAAATTCAGCCTGAAAGAACGGTTGAGATTACACCACAGGGTGCACACTGGTCAAAAACTCTTCGAGTGTGAAATTTGCAATAAAAAGTTCAGTCAGAAAGGGTACCTGAAGATACACATTAGGCTTCACACTGGTGAAAAACCTTTCGAATGTGACATTTGCAATCAAAAATTTAGTCTGAAAATTAGTATGGTGAATCACCGAAGGCTGCATACTGGTGACAAACCATACAAATGTGACTTTTGTTGCAAAGAATTTACTCAGAAAGGGAATTTGAAGTCACATCTCAAGGTGCATACTGGTGAAAAACCCTTCGAGTGTGCCATATGCAATAAAACATTCAGTCAGAAAAGGAGTATGAATAGACACCTCACGGTGCACAAGAATAAAAAACCGTTTGAATGTGGCATCTGCCATGAAAAATTTgatctggaaaatattttggaGAGGCACCTCAAGTTGCACGCTGCTGAAGGACTGTTGGAGTGTCACATCTGcaaattgaaatttattcaaaatgaagagCTGAACAATCATATCAAGTTGCACATTGATGAAAAACCGTTGAAATGTGACATTTGCAATATAGAATTTGGTTTGAGAACTTTGGAGCATGACAATTCGTATGAACACATGGCAATGAATATTGATGGAAAATCATGCATATGTGGGTCTGGTAGAATTATTAATTTGGAATCAATAAAAAACGAAGTTGATGCCGATTTCATCGAGGAAAAATGTAAAATTGAAGTTCAAACTGATGAAATTAAATTAGAAGAAAGTGATCACGTCGTTTACATAAAAGAAGAAAATACCTATTATGATGAAGAGTTTATAAGTTAG
Protein Sequence: MNTSEKPYKCDLCSSKFSDKSNLKRHVRLQHGFKPYKCKICYKKFSLKERLRLHHRVHTGQKLFECEICNKKFSQKGYLKIHIRLHTGEKPFECDICNQKFSLKISMVNHRRLHTGDKPYKCDFCCKEFTQKGNLKSHLKVHTGEKPFECAICNKTFSQKRSMNRHLTVHKNKKPFECGICHEKFDLENILERHLKLHAAEGLLECHICKLKFIQNEELNNHIKLHIDEKPLKCDICNIEFGLRTLEHDNSYEHMAMNIDGKSCICGSGRIINLESIKNEVDADFIEEKCKIEVQTDEIKLEESDHVVYIKEENTYYDEEFIS

Sequence clustering based on sequence similarity using MMseqs2