Basic Information

Insect: Chrysolina americana
Gene Symbol: topi
Assembly: GCA_958502065.1
Location: OY293421.1:5787901-5792317[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 0.0034 0.59 12.6 2.1 2 21 98 117 97 118 0.94

2 13 2.1e-05 0.0036 19.6 1.7 1 23 141 163 141 163 0.96

3 13 0.014 2.5 10.7 2.0 3 23 171 191 170 191 0.95

4 13 0.03 5.2 9.6 0.2 2 20 210 228 209 230 0.86

5 13 0.00067 0.12 14.8 1.1 2 23 281 302 280 302 0.97

6 13 0.0037 0.65 12.5 3.4 2 22 345 365 344 368 0.88

7 13 0.0011 0.2 14.1 0.4 1 23 500 523 500 523 0.97

8 13 0.0071 1.2 11.6 0.3 1 23 527 549 527 549 0.97

9 13 1.1e-06 0.00019 23.6 2.4 1 23 555 577 555 577 0.98

10 13 0.032 5.5 9.6 0.2 1 23 583 608 583 608 0.96

11 13 0.11 19 7.9 2.9 1 23 614 636 614 636 0.86

12 13 6.9e-06 0.0012 21.1 0.3 1 23 642 664 642 664 0.98

13 13 4.6e-06 0.00079 21.7 2.2 1 23 670 693 670 693 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	0.0034	0.59	12.6	2.1	2	21	98	117	97	118	0.94
2	13	2.1e-05	0.0036	19.6	1.7	1	23	141	163	141	163	0.96
3	13	0.014	2.5	10.7	2.0	3	23	171	191	170	191	0.95
4	13	0.03	5.2	9.6	0.2	2	20	210	228	209	230	0.86
5	13	0.00067	0.12	14.8	1.1	2	23	281	302	280	302	0.97
6	13	0.0037	0.65	12.5	3.4	2	22	345	365	344	368	0.88
7	13	0.0011	0.2	14.1	0.4	1	23	500	523	500	523	0.97
8	13	0.0071	1.2	11.6	0.3	1	23	527	549	527	549	0.97
9	13	1.1e-06	0.00019	23.6	2.4	1	23	555	577	555	577	0.98
10	13	0.032	5.5	9.6	0.2	1	23	583	608	583	608	0.96
11	13	0.11	19	7.9	2.9	1	23	614	636	614	636	0.86
12	13	6.9e-06	0.0012	21.1	0.3	1	23	642	664	642	664	0.98
13	13	4.6e-06	0.00079	21.7	2.2	1	23	670	693	670	693	0.98

Sequence Information

Coding Sequence: ATGAACAATCTTGATAAAATCGTGATCAAAGTACACAAGATCGCAGAAAATGGAACGGTGATTTACTCGTCAAGATTCGAAATGGATCCAAATACAAAAGAACCTATTTCAAGTACCTACCTGTCGCCGGAAAAAGTGAGTTTTGTTCTGTCGTCTGAAAATAAACTGACCCTCAATTATCAGCGATTCGAAATTGACGAGGAACACCTGAAATGCCTGAAATTGGACGAAAGCGAAGATGGTGTCCTGCCGGTGTCCGGAAAACTGGCCCTAAGTATCCCCACGATGATAAGATGCCAGAATTGCGAAACCAATTTCCCTACCAAATATCAATATCAGAGGCACCAGTGCGAGTTTAACGCAGACAAAGTTGTCTTTAAAACGGAATTTGAACACTTGGACAAAGGCGTACGCGTGAAATATTTTTGCACATTTTGCGACAAACAGTTCGTGAGCAAGAGCAATCTCGATCGTCATCTGGTTAGCCATGAAAATACGAAGGAAAATATCTGCGAGCATTGCAATAAACAATTCGTGAGCGAAAACAGACTCAGAATACACAAAGAAAACCACTGTAAGAAGGCCGGTGACATTtccaagttctacagaagcgaTGTAACAGTTTGGAAATGCAAAAAGTGCCACGAAGTTTTTTCTTCCCCGATAACGGCGAATTATCATGTATCagtttgttccgaaatcatCGATCTGGACTCCGACGAACCCGCAGAACTAGCTGGAGAGGAAGATGAGAACGCTGCTTCGAATTCAAACGACGAAAACGACAGGGACGCCTTGGCTgacgaaaatatcgaaaaaatgttGACGGAAATTTTGTTACAATGCGAGTTTTGCAACAGGACGTACGCCGAGAAGAACTTGCTATTGATGCACCAAAGAAAGCACTCCACGTCGAAAAACTACGAGTGTGTGAACTGTTGCCAGGTATTCGACTCTTACGCTACAGCTGCGCAACACTGGATGAGGAAATGTTCCGACTACGTGAGTCTTTTTTACCTTCCGAAGCTCACCTACTGTGAATATTGCGATAGGACCTTCAAATCCCACGAGCTGCTGTACACGCATAAGATCAAAAAGAAGCATTACACTTCGAAGCTGCATAAGGTGAATGTCGAGCCATCTGAGCCAGAGGAAAAAGACTCCGACACCGCCCACAAAGAAAAATGCCTCGATAACAAGGAAATCTTGAACAAGCTCATAGAAGACGTTCTAAAAACGCTCGATGTTCCGGTGAACAAAATTGCCCTCGCCCAGAATTCGCTAGAGAATGACAACGCAGACAAAAACGTAGACGATGAGGGAAACCCTATGATCGAGATCGGCGAAATTAAAACTGAAAACGAGGAAGTGTCGGGATGCAATGAAAGCAATAACGAAGTAGTGGAGAAAAAGAAAAGAGGCAGGAGACGCAAATGGCCCAAGAACCAATGCGTCGGACTGAAAAAAGTGTGTTCCGAAGTCAATCATGGGTTCAAATACCAGTGTGAACGCTGCGTCAAAGTTTTCGATAAGACTGGAGATCTGGAGACGCACCGTGAGAAAGAACACGCTTCTAGTTTCTCCTGTGAGGAATGTGGACAGgTTCTCCACAGTGCCAAGTCTTTGCTGATTCATAGTCGCGCCCACAAGAGCCTGAAACCATACGTGTGTGAAACTTGTGGTCGTAGCTATTCTCAAACTTCCCATCTTTGGCAACATATGCGATTCCACCAAGGAATAAAGCCCTTTGCTTGTCCTCACGAAGGATGCGAAGCCAGGTACACCATTCGCCCCGATCTTAAAGACCACATCAGAAAGGTCCACACGAGAGAGCGCCCCTTCAAGTGTAACGTTTGCGACAAGTGCTTCCTGACGGGCTCTGTTTACTACCAGCATCGGTTGATACACACCAACGATAGAAGATACGCCTGCGACCTTTGTCCGAAGAGATTTTTCAGAGCTGACGCTCTGAACAACCACCGGAGGATCCACACTGATGAGCGGCCGTATCCGTGCCATGTTTGCGGCAGAGAGTTTAGACAGAAGGGCGATCGTAACAAACATTTGCGAACGCAACACCCGGATAGCTTTCTGGTTTGA
Protein Sequence: MNNLDKIVIKVHKIAENGTVIYSSRFEMDPNTKEPISSTYLSPEKVSFVLSSENKLTLNYQRFEIDEEHLKCLKLDESEDGVLPVSGKLALSIPTMIRCQNCETNFPTKYQYQRHQCEFNADKVVFKTEFEHLDKGVRVKYFCTFCDKQFVSKSNLDRHLVSHENTKENICEHCNKQFVSENRLRIHKENHCKKAGDISKFYRSDVTVWKCKKCHEVFSSPITANYHVSVCSEIIDLDSDEPAELAGEEDENAASNSNDENDRDALADENIEKMLTEILLQCEFCNRTYAEKNLLLMHQRKHSTSKNYECVNCCQVFDSYATAAQHWMRKCSDYVSLFYLPKLTYCEYCDRTFKSHELLYTHKIKKKHYTSKLHKVNVEPSEPEEKDSDTAHKEKCLDNKEILNKLIEDVLKTLDVPVNKIALAQNSLENDNADKNVDDEGNPMIEIGEIKTENEEVSGCNESNNEVVEKKKRGRRRKWPKNQCVGLKKVCSEVNHGFKYQCERCVKVFDKTGDLETHREKEHASSFSCEECGQVLHSAKSLLIHSRAHKSLKPYVCETCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFKCNVCDKCFLTGSVYYQHRLIHTNDRRYACDLCPKRFFRADALNNHRRIHTDERPYPCHVCGREFRQKGDRNKHLRTQHPDSFLV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00329937;
90% Identity: iTF_00329937;
80% Identity: -