Basic Information

Insect: Chrysolina americana
Gene Symbol: topi
Assembly: GCA_958502065.1
Location: OY293412.1:92091419-92097316[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 17 1 1.8e+02 4.8 2.5 2 21 42 61 41 63 0.82

2 17 0.28 48 6.6 3.7 1 23 69 91 69 91 0.98

3 17 0.0016 0.28 13.6 1.8 1 23 94 116 94 116 0.96

4 17 0.0068 1.2 11.7 0.5 2 23 123 144 122 144 0.95

5 17 2.2e-05 0.0038 19.5 2.0 1 23 153 176 153 176 0.93

6 17 2.2e-05 0.0038 19.5 0.3 2 23 186 207 185 207 0.97

7 17 9.1e-06 0.0016 20.7 1.8 1 23 213 235 213 235 0.97

8 17 2.1e-05 0.0036 19.6 0.5 1 23 241 263 241 263 0.99

9 17 0.55 95 5.7 1.1 2 23 315 336 314 336 0.88

10 17 0.072 12 8.5 1.8 1 23 342 363 342 363 0.97

11 17 0.65 1.1e+02 5.4 2.5 2 23 367 388 366 388 0.94

12 17 0.89 1.5e+02 5.0 0.9 2 23 396 417 395 417 0.91

13 17 0.0012 0.21 14.0 0.9 2 23 426 448 425 448 0.95

14 17 1.2e-05 0.0021 20.3 0.2 3 23 459 479 458 479 0.97

15 17 2.2e-05 0.0039 19.5 0.7 1 23 485 507 485 507 0.98

16 17 0.00052 0.089 15.2 1.0 3 23 515 535 513 535 0.97

17 17 3.2e-06 0.00056 22.1 0.8 1 21 541 561 541 562 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	17	1	1.8e+02	4.8	2.5	2	21	42	61	41	63	0.82
2	17	0.28	48	6.6	3.7	1	23	69	91	69	91	0.98
3	17	0.0016	0.28	13.6	1.8	1	23	94	116	94	116	0.96
4	17	0.0068	1.2	11.7	0.5	2	23	123	144	122	144	0.95
5	17	2.2e-05	0.0038	19.5	2.0	1	23	153	176	153	176	0.93
6	17	2.2e-05	0.0038	19.5	0.3	2	23	186	207	185	207	0.97
7	17	9.1e-06	0.0016	20.7	1.8	1	23	213	235	213	235	0.97
8	17	2.1e-05	0.0036	19.6	0.5	1	23	241	263	241	263	0.99
9	17	0.55	95	5.7	1.1	2	23	315	336	314	336	0.88
10	17	0.072	12	8.5	1.8	1	23	342	363	342	363	0.97
11	17	0.65	1.1e+02	5.4	2.5	2	23	367	388	366	388	0.94
12	17	0.89	1.5e+02	5.0	0.9	2	23	396	417	395	417	0.91
13	17	0.0012	0.21	14.0	0.9	2	23	426	448	425	448	0.95
14	17	1.2e-05	0.0021	20.3	0.2	3	23	459	479	458	479	0.97
15	17	2.2e-05	0.0039	19.5	0.7	1	23	485	507	485	507	0.98
16	17	0.00052	0.089	15.2	1.0	3	23	515	535	513	535	0.97
17	17	3.2e-06	0.00056	22.1	0.8	1	21	541	561	541	562	0.95

Sequence Information

Coding Sequence: ATGACTTACTTTTCTAggaacaaaaagaaaaaaacaaggAAAAAACGACAAAATACAGATAAATCTACAAGTAAAAAACTCaaatcattcattatcaacCTCATGGAGCTTTCAATGCCACTGCATTGCAAAATTTGTGACGAAAATTACAACACAAACCATGAATTCGCCTTCCACTCCAAAGCACATGACGCAGACTTGATGTACTCCTGCCATCTATGCGAATTCAAATGCGATGCCAAAAAAGAAATCAGGGCCCACATGATGAACCACAACGTTTACAAATGCGAAATGTGCGACAAAATCTTCAAATTTAAACATGGCGCATACAGGCACGCGGAAATCCACTTGGATCAAAACAGTGTACAATGCGAAATATGCGGGAAAAACCTCCAAAGGCAATCTTTGAACACTCACCTGAAACTTCTTCACTCCGAGGAATTTTCTGGTGTGTCGTACGATTGTTCCATTTGCAAAAAAGCTTACAAATATAACTCTAGCCTCAAGAAACACATTTCTTTCAATCATAGAGAGCTCGGAATCGACGTTTCCGTCGTTTGTGACATATGCGGGAGAAGGATTTCCAGCAAAAGTAAGCTGCAGCAGCACCTCAAAATACACAGTGGCGAGAAACCGTATTCGTGTACATTTTGCGGGAAGCAGTTTCGATCCAAGGACACCATGAAATCGCACATGGTCGTGCATACTGGGGAAAAGCCCTACGTATGCGGGTACTGCGGAAAAAAGTTCGGCCAGAGTGCCCCATATCGATATCACATCAAAACTCACACCGGCGAGAAATCATCAGCTAGAAGTGCAGCAAACAACAGGTGGTCTAGGAAAAGaagaaatgagaaatccttGAATCGCAATGTGGCAAATGATGCTTTTCTAGAAAAGTTCCCATTTATTGTGAATGtcaatgaaatgaaacaatCAAAGACATGCAGTCTCTGTGAAGAGAGTTTTGAAAGGCACTTAGACTTTGCCTTGCATTCCACGGCTCACTCGCAGGACTTGGTATTTTCTTGTCATTTATGTAAAACTGAAATTAACCAAAAAATGTTGATAAAACACATGGAAATTCATGAACAATTGAAATGCACCCTTTGCAATAAATATCTCAAGAACCGAAATTACGCCAGCAAGCATTCCAAACTACATTCATTCGAAATGGAACTGGTCAAATGTCGTCTGTGCGGACAGCAACTAACAAGGAGGGACCTCAAAGACCACAAAATAAAGGAACACCAGGGATCCACGCCGGGGTCTGTCAAATGCTCGGTTTGTGACAAAGAATACCTGAGCAGGTCAAGCCTGCAGAGGCACTACTCGTCCAGTCACAAGGAGTTTGGCATTGATACCTCGAAAATATGCGATATGTGCGGAAAAGTGTACAGCAACACTCAAAAACTTCAAGAACATATAAGAATCCACACCGGGGTCAAGCCATTTGAATGTGCCCTTTGTCCAAAAAAATTCATGACGAAGCAAGTTCTGATAAAACACATGAGGTCGCACACTGACGAAAAACCACTGGCTTGCAATTTTTGCGgaaagaaattcaaatatgacggTGGGTATCGATACCATCTCAAGACACATACAGGGGAGAAAGAGCACTGCTGTCCTATTTGCGGAAGAGCTTTCATTTCCAAGTCGAATATGAAAGTTCACATGAAGGGTTGTGGAATGTCGAATTCCAAATGA
Protein Sequence: MTYFSRNKKKKTRKKRQNTDKSTSKKLKSFIINLMELSMPLHCKICDENYNTNHEFAFHSKAHDADLMYSCHLCEFKCDAKKEIRAHMMNHNVYKCEMCDKIFKFKHGAYRHAEIHLDQNSVQCEICGKNLQRQSLNTHLKLLHSEEFSGVSYDCSICKKAYKYNSSLKKHISFNHRELGIDVSVVCDICGRRISSKSKLQQHLKIHSGEKPYSCTFCGKQFRSKDTMKSHMVVHTGEKPYVCGYCGKKFGQSAPYRYHIKTHTGEKSSARSAANNRWSRKRRNEKSLNRNVANDAFLEKFPFIVNVNEMKQSKTCSLCEESFERHLDFALHSTAHSQDLVFSCHLCKTEINQKMLIKHMEIHEQLKCTLCNKYLKNRNYASKHSKLHSFEMELVKCRLCGQQLTRRDLKDHKIKEHQGSTPGSVKCSVCDKEYLSRSSLQRHYSSSHKEFGIDTSKICDMCGKVYSNTQKLQEHIRIHTGVKPFECALCPKKFMTKQVLIKHMRSHTDEKPLACNFCGKKFKYDGGYRYHLKTHTGEKEHCCPICGRAFISKSNMKVHMKGCGMSNSK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00328407;
90% Identity: iTF_00328407;
80% Identity: iTF_00328407;