Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.02 1.2e+02 4.3 0.0 24 45 81 102 70 107 0.86

2 7 0.37 2.3e+03 0.2 0.0 25 49 131 155 120 160 0.82

3 7 0.086 5.3e+02 2.2 0.4 27 48 165 185 157 191 0.78

4 7 0.0057 35 6.0 0.1 21 43 215 237 207 241 0.85

5 7 0.0079 49 5.6 0.1 13 45 235 267 231 271 0.90

6 7 0.12 7.6e+02 1.7 0.2 21 45 271 295 268 298 0.88

7 7 9.6e-06 0.059 14.9 0.2 21 45 299 323 296 328 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.02	1.2e+02	4.3	0.0	24	45	81	102	70	107	0.86
2	7	0.37	2.3e+03	0.2	0.0	25	49	131	155	120	160	0.82
3	7	0.086	5.3e+02	2.2	0.4	27	48	165	185	157	191	0.78
4	7	0.0057	35	6.0	0.1	21	43	215	237	207	241	0.85
5	7	0.0079	49	5.6	0.1	13	45	235	267	231	271	0.90
6	7	0.12	7.6e+02	1.7	0.2	21	45	271	295	268	298	0.88
7	7	9.6e-06	0.059	14.9	0.2	21	45	299	323	296	328	0.86

Coding Sequence: ATGGCAAAGAAAGGGAAAATTAAGGACGACGATACAACAATACAAATCGACGAGAGTCTGAGCAATGTGATAGTGATCGAGGACAGTTTGGACAGTGTAATCGATGTGGATATGCTGAGCGCCCAACATACGGCAACCTACTATGGCGATATACGTTGCCCGAAGTGCGGTCAAAAGTTCGAGACTGGTGCGGAGCTCGCACATCACACCGGAACAGCAGGAACCGGCTGTTCCGATATCGAGTCGATTTGCCACATTTGTATGAAAGTTGTCTCTGGACACAATAACCTCTTGAATCACATCAAAACTCATGACCTGACCGAGGAAGATGATGAACCGATCGAAGTGAAGGATGAGATAACATCGCAAGAAGACGGCGAAGAAACGGAACTGAAATGTCCGTTTTGCGGAGAAGGAGTTGGCGACGGTATGGACTTTGAAAAACACCTACACATTCATGCCTTTCCCGATTCGTCAGGTACCCGATATCCTTGCAGAGTATGCGGTAAGGAATTTAAATCACGAGGCGATTtacgtcggcatatgctacgtcATGCTAACATAAAACCATACAAGTGTATTTATTGCATTAAGGGATTCGTCACGAAAAATGAACTGCAAACTCATCTACGCTCGCATACCGGCGAACATCCGTATGAATGTGATTTATGTTTTGCCTCCTTTACAACATCGAGTTCAATGAAAAAGCATCGAAGTAAGCATACGGGCGAAACACGCTATTCCTGTTACATTTGTTCGAAAAAGTATTTCGATTCGTACGCATTGAATCGACATATTATGATGCATACAGGAGAAAGACCGTTTCATTGTAGCGTCTGTAATCGGGGATTTTGTCAGCGCGGCGATATGAGAGTTCACATGCGAATTCATACCGACGAGAGACCGTTTGAATGTCCCATATGTTTTGTAACGTTCAAACAGTCGAGCAATAGGAATGCACATTTTAAGCGTCACACCAGTCAAGCTCAGTAG
Protein Sequence: MAKKGKIKDDDTTIQIDESLSNVIVIEDSLDSVIDVDMLSAQHTATYYGDIRCPKCGQKFETGAELAHHTGTAGTGCSDIESICHICMKVVSGHNNLLNHIKTHDLTEEDDEPIEVKDEITSQEDGEETELKCPFCGEGVGDGMDFEKHLHIHAFPDSSGTRYPCRVCGKEFKSRGDLRRHMLRHANIKPYKCIYCIKGFVTKNELQTHLRSHTGEHPYECDLCFASFTTSSSMKKHRSKHTGETRYSCYICSKKYFDSYALNRHIMMHTGERPFHCSVCNRGFCQRGDMRVHMRIHTDERPFECPICFVTFKQSSNRNAHFKRHTSQAQ

Sequence clustering based on sequence similarity using MMseqs2