Basic Information

Gene Symbol
MBD2
Assembly
GCA_963669355.1
Location
OY770262.1:3888616-3896266[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1e-07 0.001 20.1 0.0 1 37 5 42 5 83 0.72
2 2 0.00022 2.2 9.4 0.0 29 74 137 190 91 193 0.88

Sequence Information

Coding Sequence
ATGAATATTTCGATCGAGCGGAAAAAGCCggattgtaatgttctgccgcCGAAGGGCTGGCCACCGCGGGAAGATGTTATGCGAAAGACCCTTTCAGCCGGGAAAGTCGATGTTTACTATTACAGCCAAGGGCTTGGTGTTGGTGGCGGCGGTgctcctaaaaaaatcaccgaTACAAAATCACAGCTAGCGCGTCAATTAAGCGACACACTAGACGTAACACCGATCGATTTTCAAAGCGGGAAAATCCTTTCGAATGCCCAACCGATTACGCTTCAACGTAACGCTTCGAGTTCGTTAAAACGTAAATTAACAACAACAGGAACTGGAACAGGACCAACGAATTTATGTAGTCCGGGCGGTAGTGTTTCGTCGGCACTTCGTCATCATCTCGAATTCAGCAGAGGACTACGAACAGACATATCTTTAGTGCCGCCGATTCGTCAGACAGCATCGATTTTCAAGCAACCGGTAACCGTTTATAAAACGCAAGATGGTAAAgtgaaaaatgatttgaaacaTGGAACCCAGGAGAAACCGAAACAATTATTCTGGGAGAAGCGTCTGGAAGGTTTACGATCGTGCGATATTACTGGCAGTGAATTCGGTCCGATCGATTTACCGCGCGGCATTAAACCGGTCGGTCCGAACGTATGCGAACAAACACTTCTACAATCGGTTGCGACGGCCTTGCACGTTTCCAGCCAACCAGTTACGGGACAAACGACGGCCAAACAAGTTCTATGTGCCAATACCGGTGTGTTCTTAAATCCCGATCAGCCCTTGATGCATTCGATTAGCATAACCGAGGACGATATCCGGCGACAAGAGGATCGTGTTACGCTCGCTCGACGAAGACTGCAAGAAGCTCTTAAGGCATAA
Protein Sequence
MNISIERKKPDCNVLPPKGWPPREDVMRKTLSAGKVDVYYYSQGLGVGGGGAPKKITDTKSQLARQLSDTLDVTPIDFQSGKILSNAQPITLQRNASSSLKRKLTTTGTGTGPTNLCSPGGSVSSALRHHLEFSRGLRTDISLVPPIRQTASIFKQPVTVYKTQDGKVKNDLKHGTQEKPKQLFWEKRLEGLRSCDITGSEFGPIDLPRGIKPVGPNVCEQTLLQSVATALHVSSQPVTGQTTAKQVLCANTGVFLNPDQPLMHSISITEDDIRRQEDRVTLARRRLQEALKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00202584;
90% Identity
iTF_00202584;
80% Identity
-