Basic Information

Gene Symbol
-
Assembly
GCA_949316135.1
Location
OX438618.1:5381829-5400806[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 3.2e-12 8.3e-09 35.3 0.1 7 49 188 232 184 234 0.87
2 7 4.8e-13 1.3e-09 38.0 0.1 4 49 229 276 228 278 0.88
3 7 4.8e-13 1.3e-09 37.9 0.1 4 49 273 320 272 322 0.88
4 7 4.8e-13 1.3e-09 37.9 0.1 4 49 317 364 316 366 0.88
5 7 3.4e-13 9e-10 38.4 0.2 4 49 361 408 359 410 0.87
6 7 6.3e-13 1.6e-09 37.6 0.1 5 49 406 452 405 454 0.88
7 7 1.5e-16 3.9e-13 49.2 0.0 4 70 449 513 447 517 0.89

Sequence Information

Coding Sequence
ATGTCGGATGAAATGGCGGTGATTGAAAACGTAACAGGCGAAGAGCCTAAATTAAATGGAGATGAGGTGTCGGAAGCAAGTACCGCTAATACGGAGCAGGTCAAGGTGGAGCCTTCCAGTGACCCACCAGCCCCTCAACATGAGGAACCAGCCGTAGGAACGGATGAACCTTTGGAAGATGGGACGGAAGATTCAGATGACAAGCGAGGCATCAAGAGGAGAGCGTCGGCCGCTTTCAATGATGACGGAACTGAACAAGATTTTAAGGGATTTGACAAGATCACAGATCCCGATGACTCTATGTTAGAGTCTAAACGTGTTTTGGAACGCTTGGAGGCGAAAGTGTCTGCGGACAGTAAAGGCTTCACTCCACTGAAGCATCTGGGTTCGCTCACTGCTGGGTTACGAGCATCCAAACGACCAAGACAAGACACTGatggaTCAAGACCATCATCAGCACTCTCATCAAGGTCAGACGGTGACACTCACACTGATGTGAGTACAGGCATGTCCCCGCTGCGGCGGCGCGCCACAGTGGAGCGCGAGATGGGCTCCGTCCTACTGCGCGCGCCGTTGGACGCGGGCTGGCGGCGCGAGCTCGTGTACCGCGCCGCGCTCGACGCGCACAGCCGCCGCACCGGCGACATCTACTACTACACGCCGCAAGGGAAGAAGCTGCGCTCCACTAGAGAGCTGCGCGCGCCGCTGGACGCGGGCTGGCGGCGCGAGCTCGTGTACCGCGCCGCGCTCGACGCGCACAGCCGCCGCACCGGCGACATCTACTACTACACGCCGCAAGGGAAGAAGCTGCGCTCCACTAGAGAGCTGCGCGCGCCGCTGGACGCGGGCTGGCGGCGCGAGCTCGTGTACCGCGCCGCGCTCGACGCGCACAGCCGCCGCACCGGCGACATCTACTACTACACGCCGCAAGGGAAGAAGCTGCGCTCCACTAGAGAGCTGCGCGCGCCGCTGGACGCGGGCTGGCGGCGCGAGCTCGTGTACCGCGCCGCGCTCGACGCGCACAGCCGCCGCACCGGCGACATCTACTACTACACGCCGCAAGGGAAGAAGCTGCGCTCCACTAGAGAGCTGCGCGCGCCGCTGGACGCGGGCTGGCGGCGCGAGCTCGTGTACCGCGCCGCGCTCGACGCGCACAGCCGCCGCACCGGCGACATCTACTACTACACGCCGCAAGGGAAGAAGCTGCGCTCCACTAGAGAGCTGCGCGCGCCGCTGGACGCGGGCTGGCGGCGCGAGCTCGTGTACCGCGCCGCGCTCGACGCGCACAGCCGCCGCACCGGCGACATCTACTACTACACGCCGCAAGGGAAGAAGCTGCGCTCCACTAGAGAGCTGCGCGCGCCGCTGGACGCGGGCTGGCGGCGCGAGCTCGTGTACCGCGCCGCGCTCGACGCGCACAGCCGCCGCACCGGCGACATCTACTACTACACGCCGCAAGGGAAGAAGCTGCGCTCCACTAGAGAGgttgCCGAACACCTTGCTGGCACTGGATTGACTTTGGAAAACTTCTCTTTCTTCAAAGAACCGCTTGGCATTGATGACCCTGAGAAGGAAATaataagAGATGCAAAACTAATGCGTCGCGTGGAGTCTCCAGTCCCTACACCGCCTGTTACAGTCGAGGGCAAAAGACAACCGAAACCGAAGGCACCCAAAGGAGCCAGCCCGGAACCTTCACCGAAATCACCAGCAGCCAGACTAAAGGTGAAGTCAGTGGGGTCTCGTTTGAACAACAGTGGTGCCACGCctacaaacaagcagacgaagAAACCTCAAGCAACTCCTACCACTGATAACAACAATACCGCCGCCTGGAAGAAGCCCAGGCTCGGCTCCGCCCCGCCCTTGGTACCGGCGCCGCAGCCAACGCTCCTGCCCAGGCCGGAATTGCAGTCACCTGATATGCAAACGGGCAGACAGTTGCTGCAGCCGTGCTCCATGAGCTGCGGGCGCGGCGTGCCGTCGCTGGCGTGCGCGGCCTGCCTGTGCCTGTACCATCCGCACTGCGTCGGGCACTCGCAACCGGACAGCGACGACTTCTTCTGTACAAACTGTCGCAAGTCAACGTCTCCTCCTTTGGAGCCCCCACCTTTGGTTCACAAGTCGGGCTCAGCCCCGCGCCGCACCTCCGTCCCGCAAGGGAAGCCGCCCGCCGACAAGAGAGTACTACTCAGGATGAAAGTGTCCGGCGGTGGCCCGGACGGCGAGCGTGTATGGGCGGTATCCCGTCCCACGGCACCGCCGGCCCAAGCACGGGCCGCCTTGCCTCAGTCGCTGGCCATGCTCAACGGTCGCAGGTTCATTGTCGTGCCAAGGAACGTCGTACTGCCCGTCACGCAGCCCGGTGAGGACAAACGTCAGAGCCGCACCCGGTCGTGCAATGGCGTGACGTCACCGTTAACGTCGCCGCGGCGCCGAGGGAGGCCGAGGAATGACGACACGGATCACTTCACTGCATTCTACAATACGGCCCAGCAGCACAACTATAATGTCGTCATACAGatattcCAATACCTGGGCATGCGGGACTTGGCGAGAAGCGCGCGAGTGTGCAAGCTGTGGCGCGAGCTGGCCGCCACGCCCGCACTGTGGAGACACGTGCGGATGAAAAACTCACACGTAAGTGATTGGGGAGGATTGTGCACAGCTCTCAAGAAGCACGGGACGAAATGGTTAGATCTACGCAAGATGTTACTGCCACAGAACGACACCGTGTTTTGGGAACAGTTCGCTCAGCACATAGCAGCGGTCGACACCTTGGAGAGGATAGAGATGTGCCGCTGCCCGGCGCGCGCCGTGGAGGGCGTGTGCCGCGCGCTGCCGGCGCTGCTGGCGCTGTCGGCGCCCGCCATACGCGACGCGCGCCTGGACCCCGGCCCGCTGGCGGCGCTGCGCCGGCTGCGCGAGCTGCGCCTCAAGTCCATGGCCGGCCTGGCGCTCACCACCGACCTCACGGCGCTCAGCGCGCTCACCGACCTGCACCATCTCTCGCTCACGTCTATCAAGGAGCTCGGTTGGTGTGCATGCGACGTGATTGGCTCGCTCAGACAGTTGGAGTCATTAGAACTGGGCGAATGTACGTTCCGCGCGGAGTTCGGACAAGTACTGCGGCAACTGACCCGCCTGCGTCGCTTGCGCCTAGAGCGCGGTACAGCGGCGTGCGCGGCGCCTGCCTTGCTGCGAGCGCTGGCGCAGCTGCCCAGCCTCACCGCGCTCGAGCTCGTCAACGTCGACGTCAAGGTTGGCTTTGACGATGCCCTGGCGGAGTGTAAAAACATACAGCGGTTGTTAATCATACCGACATACGTGTCACAATCTGCCACTACTAATAAACAGGTCCTGAGCGGCGTCCTGAGACTAAAAGACACACTCACACACTTAATGTGGGGTGTGACCATCGAGTTACTTCGCGTAACAGAGCTCTTCATAGACCAGTGCGAGCAAGGCGGCGATGACAGTAAGAAGAAGGACTTTGGCGAGTGCATCCCTGTGCTCAAACCGGTGCCCGGGTTCAAGCTACCTGATCAGCATCACGTTGCTGGACCGCCACAGGTTGAGATCCTGCCGTTGCCGACGCTACAAAAGCTGCTGTCAGAGCAGTTACCAAACACCAAACTCAAACTGTTACGCATCCCCTTCCACGCCACCTGGCGGCAGTCACTCGCGGACTTTCAATAG
Protein Sequence
MSDEMAVIENVTGEEPKLNGDEVSEASTANTEQVKVEPSSDPPAPQHEEPAVGTDEPLEDGTEDSDDKRGIKRRASAAFNDDGTEQDFKGFDKITDPDDSMLESKRVLERLEAKVSADSKGFTPLKHLGSLTAGLRASKRPRQDTDGSRPSSALSSRSDGDTHTDVSTGMSPLRRRATVEREMGSVLLRAPLDAGWRRELVYRAALDAHSRRTGDIYYYTPQGKKLRSTRELRAPLDAGWRRELVYRAALDAHSRRTGDIYYYTPQGKKLRSTRELRAPLDAGWRRELVYRAALDAHSRRTGDIYYYTPQGKKLRSTRELRAPLDAGWRRELVYRAALDAHSRRTGDIYYYTPQGKKLRSTRELRAPLDAGWRRELVYRAALDAHSRRTGDIYYYTPQGKKLRSTRELRAPLDAGWRRELVYRAALDAHSRRTGDIYYYTPQGKKLRSTRELRAPLDAGWRRELVYRAALDAHSRRTGDIYYYTPQGKKLRSTREVAEHLAGTGLTLENFSFFKEPLGIDDPEKEIIRDAKLMRRVESPVPTPPVTVEGKRQPKPKAPKGASPEPSPKSPAARLKVKSVGSRLNNSGATPTNKQTKKPQATPTTDNNNTAAWKKPRLGSAPPLVPAPQPTLLPRPELQSPDMQTGRQLLQPCSMSCGRGVPSLACAACLCLYHPHCVGHSQPDSDDFFCTNCRKSTSPPLEPPPLVHKSGSAPRRTSVPQGKPPADKRVLLRMKVSGGGPDGERVWAVSRPTAPPAQARAALPQSLAMLNGRRFIVVPRNVVLPVTQPGEDKRQSRTRSCNGVTSPLTSPRRRGRPRNDDTDHFTAFYNTAQQHNYNVVIQIFQYLGMRDLARSARVCKLWRELAATPALWRHVRMKNSHVSDWGGLCTALKKHGTKWLDLRKMLLPQNDTVFWEQFAQHIAAVDTLERIEMCRCPARAVEGVCRALPALLALSAPAIRDARLDPGPLAALRRLRELRLKSMAGLALTTDLTALSALTDLHHLSLTSIKELGWCACDVIGSLRQLESLELGECTFRAEFGQVLRQLTRLRRLRLERGTAACAAPALLRALAQLPSLTALELVNVDVKVGFDDALAECKNIQRLLIIPTYVSQSATTNKQVLSGVLRLKDTLTHLMWGVTIELLRVTELFIDQCEQGGDDSKKKDFGECIPVLKPVPGFKLPDQHHVAGPPQVEILPLPTLQKLLSEQLPNTKLKLLRIPFHATWRQSLADFQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-