Cfor029123.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Chloromyia formosa
Gene Symbol
MBD-R2
Assembly
GCA_964017055.1
Location
OZ024817.1:4604409-4608124[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.5e-15 2.1e-11 44.4 0.0 3 76 426 497 424 498 0.93
2 2 1.3 1.1e+04 -2.7 0.0 35 46 727 738 726 740 0.85

Sequence Information

Coding Sequence
ATGACGCGTCGTTGCATAATCGAAGGTTGCACGTCAAAATCGAGTAATCCGCAACATCAGGGCGTCACATTTCACTCGTTCCCGTTCGATTCGAAGACACGCGAAATTTGGATTGCCAATTCGCGCATAAATCCGGAAAAGAACATCACAAAAAGTGTGCTAGTGTGTTCGCGACATTTTCGACGTGTCGACTTCCAGCCGGCCAAGTCGAATAAGTATTTGCTAAAGCAGGGGGCGGTGCCGACCATTTTTCCGTGGGGACGTTTTCCTCCGCCCAACACCACCGCCACGGCAGGTGAAGCTCCTGCCACTCCTGCGACGGAGACGTCGAATGAAACGTCGACATCGAATGAAGCGTCGATCACCAATGAAGCGGTGGCGCCAAAGCCAAACCCTTTAGTTCAACTGGAAAGTGAAATGGAGGCATTGGCCGGTTCCATCGCCGCGGGCTTGGAGGAGAGTCCGGCGGACAAACCTATGCTCAAACGAGCGCTACAGGACTCTCCGACGGTATCAGACGCCAAAATGCCGAAACTCACCGTCACCTCTCCAACGGCTGCCGCTGCCGATATTCAAAATCTGGTCCCGATAGGAACAATACCCGCGCCAGCGGGCGGTCGCAAGTCCGAGACAGTATCCGGTTTCGTCCCGGGCGTGCGACTTGAAGCCCAAGACTTCGACGGTGTATGGCACACAGCACGTGTGGTGGAGGTGGACAACGACGAGCGAGAGGTCCTCATACAGTTCGAGAAGAGTGGCAAATCAAAAGGCCCGAGCGGTGTCGAAGAATGGATTCCCATGAACAGCAGTCGCCTGCGCCAGAAAATCAGCACGCCCACAAAATCCCCGAACGTATTTGTGCTCGGTGAAAAGTGCCTGGCACGTTGGAGTGGCGCGCGACGCTTCCCGGCCACGGTGCACAAAGTGCTCGAAAACGACATGTACGAGATCCTCTTCGACGACGGCTACATGAAAGTGCTGAAAAGTGCTCACATCAGCAAGCTAAAGGTGCCGATTAATAAACAATCGCCGGCCGGGGCGTCAACGAGCCCCGTGATGGCACAGAAACCGACCGCCAGTTCCACGCCCGAGAAACCGAAATCAAAGACTCAAACACCGCGCAAGGACTGGCCACTCATTTCGATGAGCTCGTTGAACCTTGCCGAGCTCAACTTGCCCGAGATCCCGAAGGACGGCGAATGGTGCTGTCATTGGGTCAACGATCAACCGATCGGACGTGAAGGATATCTCACAGTGGGCGATCACAAGAAACCGACTGTTATCGTGGACGATTGGCGTCTGCCGCCCGGCTGGACAAAACACATGTACCAGCGCTCCAATGTTCTCGGCAAGTGGGACGTGATTCTGGTGAATGAGAACGCAAAACGCTTCCGCTCCAAAGCCGATCTGAAACTTTTCATAGAGGATTTGGGTCAGCACTACAACCCGGACGTGTATGATTTCAGCATTCATCGACGCCGTGCCAAAGATATCGGCGCATATGCTTACACGAAGGACTATAAGCCTCCGCAACCGGTGAAACCACCGCCGCAACTATTAGAGCCTCTGCCACCGCTTCAGCCGGAAACATTCTTGCAAAACACGGGGCAATCGTCAGCAGTGGAGAATATACTGGCCGCGTCGACGGCGGCGGCGGCGACTCCATCGCCGCTATTCGAACCGCCGCCGCCTGTAAAGTCCGTGGAGGAGGCGATTCCACCATTGGATGACGGCTATGTCTACGTGGGGTCGCTAAAAGTTCAGATCATCGACAATCTATTCCGCTGTCCGAAAGAAGGCTGCAACAAGAATTTCCGCAAGGAGAACCACCTGCAGATTCACATCAAACATTACCACGAGGATATTGTCAAATTTCTGGGCGATTGTCCCAACATGCAAGAGCTGGCCTGCAAACGTACCATCGGCCATCCGCCCGACGAGCCGCTACCCAAAAACTACCTTCCCAACTCCCAATACTTTGCAAAACTCCATCAGCAGGACATTCTAAATCGCACTCATCGCAAATCGACAAACACTCCACTCACGGCAAACGCAGCAAGCACGTCTGTCGATAGTTTTCTAATGTCAACGACAGCCGACGATTCGTCGAAATTAATGGATGTCACAATGTCCGATATCACGGCCGCTTCAACAACACTCCCGGCAAGTCCATCATCATTCATACATCCAACGGGTGACGAAATGTCTTCGCTTGCGGACGAGCTGATGGCCACGCCTCAGTTGCCATCGACTTCGAAATCGGCATCCCGGAAATCGGGCGATCGCAAGAGTTCACGCCAACGTCTCACGAAAAAATATGTCACAGCAAGCACATCCAATCTGTTCGACACATCATCATTCCAATTGCCCGATTCCGAGGAGACGCGACACTCGTTTAACCGGACGCCCGAGCATCAGCAACGAGCCGCCAAAAAGGCCAAACTCTCACACCCGACCCCTGTACAGGACGCGAACATGGACGGCAACACAACAACAGTAAGTGTTCCCGATCAGTCGCAGCTACCGCCCAATCAAAGCCCGAAATACATCCAAGAGAACGGTGAGGTCATCAAAATAGTGCGCATGCGACAGGAGGAAATAATCAACTGCATCTGCCAGTTCGGCGAGGAGGACGGTCTCATGATACAGTGCGAACTTTGTCTGTGCTGGCAGCACGGCATCTGCAACGGAATCGAGAAGGAGTGTCAGGTGCCCGACAAGTATGTCTGCTACATTTGTCGCAACCCACTGCTGGGACGCGAAAGTATGCAATACATTCACGATCAGGACTGGCTGTACGAAGGCAAGCTGCCGACCGGCAACTATCACGGCCCCAATCCCAAGTTGCAGGATCGCTTCAACATTTTGCGAACAAGCCACACGCTCACGGGCAATCTGGTGGAACTGAAACGATTCTTGCACAGTCTTCGTGTCAAAATCAACATGGCCCAGAACAAGGATCATCCGAAAATGTATTTGTGGGCGAAAAAGTGGGAATCGTCACCGCCGCGCAGTACCGAAACCAAAGTGGAAAAATGTGACGATATGGAGGCGGCAATGAAGGAGGAAACATCTGCGGGAGAAGGTCCGTCAGACATGATAACTGCGGGTGGCGTAGGATCAGCTGATAATCTAGAGTTGAAGGAGGAAACGGACCCAAAGCAGGAAATCAAAATACAGCTGCCAAATATTCCGCAACCGGAGGCGGCAATTGATCCGGTCGAGTGTCAGCATCGTCTCTTGGAACATATTCAGAAACAGCAGTCGTTGGCAGTTGAACGGTTGCAGGATATTGAGTCGGATATTAATGAGTTGGAATCACTTGATCCGTCAGGCGATATGGATCCCAATGAATTTTCGCGAACCAAAAAGACATTGGCAATGCTTATTAAGGATTTGGAGACTATGCAAAATCTAGCGCTGATCAATAAAGCTCCGGTAAACAGATTTGCCCCAGTCGCTTAA
Protein Sequence
MTRRCIIEGCTSKSSNPQHQGVTFHSFPFDSKTREIWIANSRINPEKNITKSVLVCSRHFRRVDFQPAKSNKYLLKQGAVPTIFPWGRFPPPNTTATAGEAPATPATETSNETSTSNEASITNEAVAPKPNPLVQLESEMEALAGSIAAGLEESPADKPMLKRALQDSPTVSDAKMPKLTVTSPTAAAADIQNLVPIGTIPAPAGGRKSETVSGFVPGVRLEAQDFDGVWHTARVVEVDNDEREVLIQFEKSGKSKGPSGVEEWIPMNSSRLRQKISTPTKSPNVFVLGEKCLARWSGARRFPATVHKVLENDMYEILFDDGYMKVLKSAHISKLKVPINKQSPAGASTSPVMAQKPTASSTPEKPKSKTQTPRKDWPLISMSSLNLAELNLPEIPKDGEWCCHWVNDQPIGREGYLTVGDHKKPTVIVDDWRLPPGWTKHMYQRSNVLGKWDVILVNENAKRFRSKADLKLFIEDLGQHYNPDVYDFSIHRRRAKDIGAYAYTKDYKPPQPVKPPPQLLEPLPPLQPETFLQNTGQSSAVENILAASTAAAATPSPLFEPPPPVKSVEEAIPPLDDGYVYVGSLKVQIIDNLFRCPKEGCNKNFRKENHLQIHIKHYHEDIVKFLGDCPNMQELACKRTIGHPPDEPLPKNYLPNSQYFAKLHQQDILNRTHRKSTNTPLTANAASTSVDSFLMSTTADDSSKLMDVTMSDITAASTTLPASPSSFIHPTGDEMSSLADELMATPQLPSTSKSASRKSGDRKSSRQRLTKKYVTASTSNLFDTSSFQLPDSEETRHSFNRTPEHQQRAAKKAKLSHPTPVQDANMDGNTTTVSVPDQSQLPPNQSPKYIQENGEVIKIVRMRQEEIINCICQFGEEDGLMIQCELCLCWQHGICNGIEKECQVPDKYVCYICRNPLLGRESMQYIHDQDWLYEGKLPTGNYHGPNPKLQDRFNILRTSHTLTGNLVELKRFLHSLRVKINMAQNKDHPKMYLWAKKWESSPPRSTETKVEKCDDMEAAMKEETSAGEGPSDMITAGGVGSADNLELKEETDPKQEIKIQLPNIPQPEAAIDPVECQHRLLEHIQKQQSLAVERLQDIESDINELESLDPSGDMDPNEFSRTKKTLAMLIKDLETMQNLALINKAPVNRFAPVA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00322536;
90% Identity
iTF_00322536;
80% Identity
iTF_00322536;