Basic Information

Gene Symbol
-
Assembly
GCA_963691955.1
Location
OY829906.1:8823878-8824562[+]

Transcription Factor Domain

TF Family
HMGA
Domain
HMGA domain
PFAM
AnimalTFDB
TF Group
Unclassified Structure
Description
This entry represents the HMGA family, whose members contain DNA-binding domains, also known as AT hooks due to their ability to interact with the narrow minor groove of AT-rich DNA sequences. They play an important role in chromatin organisation [1]. The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [2].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.0034 81 3.4 3.6 11 21 13 23 11 24 0.71
2 4 0.095 2.3e+03 -1.2 2.1 12 15 35 38 34 39 0.93
3 4 4.1e-10 9.9e-06 25.5 2.2 4 21 56 73 54 74 0.87
4 4 1 2.4e+04 -4.6 3.3 10 14 88 92 87 93 0.66

Sequence Information

Coding Sequence
ATGTCTGACGACGGCGCAGCAGTTGTTGAGAAGAAAGGACGCGGAAGACCCAAGGCTAACGGAAACAAAGCTGACGCTGAACCCAAAGCAGATGCTAAAAAACGGGGTCGGCCACCAGTGGCTACTAAACCAGCAAAAGAGTCCGCTAAGTCATCTGATGATGAGCAGGCGCCAGTAGCAAAACGCGGCCGCGGCAGACCGAAGGGTTCTAAGAAGAAGGCCCCCGCAGCTAAAGCAAAGagtGCATCAGAATCTAAAGGTCGCGGACGGGGACGTAAGGAAGCTCCTCCTAAAAAGGATGCTTCATCTGAAGAGGAACAGGAAGATGATGAGGAAGAAGAGGGCTCCGATGAGTAA
Protein Sequence
MSDDGAAVVEKKGRGRPKANGNKADAEPKADAKKRGRPPVATKPAKESAKSSDDEQAPVAKRGRGRPKGSKKKAPAAKAKSASESKGRGRGRKEAPPKKDASSEEEQEDDEEEEGSDE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01161391;
90% Identity
-
80% Identity
-