Basic Information

Insect: Chironomus tentans
Gene Symbol: PAX6
Assembly: GCA_963573255.1
Location: OY754302.1:55113110-55121055[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 4.1e-35 7e-32 110.2 0.0 23 125 85 182 70 182 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	4.1e-35	7e-32	110.2	0.0	23	125	85	182	70	182	0.93

Sequence Information

Coding Sequence: ATGTTAATCGGATCTGCTATAGGAAGTGAGTTACTATCTTTACCATCATCAACTACTCCTTGGACGATGGATGCACCACCTCGTTCGAATCCAACCGGCGGAATAGCTCCAAATCCATTACCATTATCACCAACCGTGGGAATGACaccaaatttaaatgttaatgtACCTGGTTCATCGCCAACGACGCCCGCTGCTGCAACATTATTTTCAGGTGCACCGAATGCAAATACACTTGGTGCTCTTGTGTCACAACACAGATTACTCGAATTATCGAGATTTGGATTAAGAGGCTATGATTTGGCTCAACACATGCTGACACAGCAAGGAGCTGTTTCAAAACTGTTAGGAACACTTCGACCACCTGGTTTGATTGGTGGATCGAAACCAAAAGTTGCAACGCCGGCTgttgtatcaaaaattgagCAGTACAAACGAGAGAATCCAACAATATTTGCTTGGGAAATTCGTGAAAGATTAATATCTGAAGGTGTTTGCACAAATGCAACGGCACCGTCAGTTTCTTCCATTAACCGAATATTAAGAAATAGAGCAGCTGAGCGGGCGGCAGCAGAGTTTGCAAGAGCCGCCGGTTATGGACTTTATCCTCCACATCCATATTCAGGGTTTCCATGGCCATCGCCAGCACATATGTGGCCAGCACCAGGAATGCAAAATATGACATCACCTGGATCAGCTTCCACACCAAGAACATTAGGATCACCAAATTCTGGCTCTCATGATACACTAGGGTCACCGGATGGCAATAGATTAATTGATATTGAGGGAGAGGATTCATCAAGTTTAGATGGTGATCAACCAAAATTTAGAAGAAATCGTACAACATTTAGTCCCGAGCAACTCGAGGAATTAGAGAAAGAATTTGACAAATCACACTATCCATGTGTCAGTACACGAGAGAGGCTTGCAGCACGAACTACCCTTAGCGAGGCGAGAGTTCAGGTTTGGTTTTCGAACAGGCGTGCGAAATGGCGTCGTCACCAGCGAATGAACTTGCTGAAAAGAAATTCATCGCCAACTCAGCGTCACACAAACACGAGCTCAGCTTCAAATCAAATCGGTTTCACCCCTGGCTCGCCGCAAAATGTTCCACAAGCAGCACAAGCTGCAACAACGCAAAGCCAAATATCACCACAACAACCACATCATTCAACAGGAACCACTCAAAATCACCAGAGCAGTGCGACAACACAACAGGCGATCGTGTCATCAGCCACAGCATCAATTCCATTATTAATGGGCGGTGAGCATTCAGCATTTCGAGCACTTAATCCTCTCAATCCATCAACGGCTGCACTTTTGGCAGCATCTGCACAGTTAGGATTAGCACGATCGTATCTTGCTGCATCtgagcatcatcatcatctcaataacaacaataataatagcagtaacaataataatattgcatCTTCAACCTCAACCAATCAATCACCTCCAATAAGTCCACATCCAAGTGAGTctgatgaagaaattaatgTGCATGACGACGAATCGGACACAGAACTAActaataattcatcaaaaaataattctcatatAGGATATAGCAATAGCAAGACACCTCTCGAATTGACAAAGCATGATCGTAATTGA
Protein Sequence: MLIGSAIGSELLSLPSSTTPWTMDAPPRSNPTGGIAPNPLPLSPTVGMTPNLNVNVPGSSPTTPAAATLFSGAPNANTLGALVSQHRLLELSRFGLRGYDLAQHMLTQQGAVSKLLGTLRPPGLIGGSKPKVATPAVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSSINRILRNRAAERAAAEFARAAGYGLYPPHPYSGFPWPSPAHMWPAPGMQNMTSPGSASTPRTLGSPNSGSHDTLGSPDGNRLIDIEGEDSSSLDGDQPKFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLAARTTLSEARVQVWFSNRRAKWRRHQRMNLLKRNSSPTQRHTNTSSASNQIGFTPGSPQNVPQAAQAATTQSQISPQQPHHSTGTTQNHQSSATTQQAIVSSATASIPLLMGGEHSAFRALNPLNPSTAALLAASAQLGLARSYLAASEHHHHLNNNNNNSSNNNNIASSTSTNQSPPISPHPSESDEEINVHDDESDTELTNNSSKNNSHIGYSNSKTPLELTKHDRN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00319644;
90% Identity: iTF_00319644;
80% Identity: iTF_00320425;