Basic Information

Gene Symbol
E2f8
Assembly
GCA_013357705.1
Location
NW:381719-384725[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 1.6e-22 4.2e-19 67.3 0.2 1 65 77 145 77 145 0.90
2 3 1.5 3.8e+03 -3.1 0.0 37 43 166 172 151 173 0.68
3 3 7.4e-19 1.9e-15 55.6 0.1 2 59 215 297 214 303 0.89

Sequence Information

Coding Sequence
ATGTCAGAAATTGGACCAAGTACTCCAGATCGTATAGTTCTtggagaattaattaatagtacaAAGTTAGAGCCAATTTCACCAACAGCTAACTTACGTTTACTTACTTCATTAGCATCTAATCTAAAAAGTGTCTCTCGATCTGATCGAGAAAGTCAAAACAAAATTCAAGTCAATCAATGTTCTCCAATCGCATCTGGATCTGTTGATTCAAAAACAGGCTCTAGAAaacaaaaatctttaaaattaatatgtgAAAAttttttagGCTTCTATCGCTTGgatgttaaaaatgatgtgGTGCAGGAAATTCATTTAGACAGTACTGCTAAATCTCTAGGAACAGAGAAGCGAAGAATTTAtgacataattaatattttggaAAGTTTAGACATGGCTTCAAAAGCCGGTAAAAATCGGTATCTCTGGCATGGGCAAAATAATTTGACATCAACACTTGCAACTCTGAAGTCAAGAGCAATCAATTTAGGACTGAAAAAACGTATACAAGATATCCAAAAAACTGATAGATcatatattgaagaaaatgatgacaatatttattgtaataatgaatcaattacATTATGTGAAGAATTAGCTGATGAAAAAAGCTATGATAATGAGACTGCAATAAAGGAAGATAAAAGTTTGGGAGCAATGTGTCGAAAATTTATCATGTTATTTCTTGTGTCTATGAagaaTGGTGTCATTAATTTAGACATAGCAGAAAAAGTACTGATTTCGGAATTGGACACTCCAGAAAAACTGAATACTGTATCTAGATCTCACAGAACCAAAGTTCGACGATTATATGATATTGCTAATGTTTTAACAGCTATCGGACTCATTAAAAAAGTGTCATTACCTGacagaaatttgaaaaaacctatttttaaatatacaggACCAGAAATTGAATCTACAAATTCCAGtcaaaacaCTCCAATTCACCAAATTTATGACTCGCCAATTAAAATGACCACTCCAAAAAAACATATCACACCACTTTCGGAACAGATGcatattaattctttaattaattcggattttaaaaatttatcaaatatctCACATTCTGTTCCATCTACTGGGTATTCCCAAAATACTGTTCCACGCACTCCATTAACAGACGGACGAAGATATAGGAAAAGGAAATTATTTGAGTCAGATACATCATTCCCAAAGATTCGTAGTCTTCCAAATTTAGATAGAACTCGTTTGACTGAAGGTTTAGATGATTCATTATGTCGTGTAGTAGAAAtggaatatgaaaaaatgaattccaACAATGAATTACAAGAGCCGAAACCAAAAGCATGTACGAAATTATTTCCAAAATTTAATTCTGATTCATGTCTAAAAATTACAAACAGAAAAACTGTAAAACCTATTCAAGTGAGTGGAGAAATGCGTTCTTTAAATCATATCATTTCAATTTCTGACAAAGGCAATGCAACAACTATTACTTTTGAAAACTCTCCTCCAATGTCACAGActccaattaaaaataaaacgatgCAGCCTATTTCACTGGCTGCTATCATTATAGCCAATGctaatcaaatattaattccGCATAATACatctaatattaaaaagaatcaTGAAAAAGtatgcaataataaaaatcagacTGAAGTAAAATCTGTGAAGACCATAAAAATACCTGCGTCCACAGCAAAGCCTCAGCAAGTGGCAATAGAAAAAACAAGTAATTCAGACACGAACTATGTGAAGGTGCCTGTGGGACAAGCATCAAAGCTATCACCAGGAGATATTCTAGAAGTAGTTCAGGCTGGAGAAACTTTGCAGTTAGTAACAATAAAGACCAGTAATAGTTTCAAGAATCGTTAA
Protein Sequence
MSEIGPSTPDRIVLGELINSTKLEPISPTANLRLLTSLASNLKSVSRSDRESQNKIQVNQCSPIASGSVDSKTGSRKQKSLKLICENFLGFYRLDVKNDVVQEIHLDSTAKSLGTEKRRIYDIINILESLDMASKAGKNRYLWHGQNNLTSTLATLKSRAINLGLKKRIQDIQKTDRSYIEENDDNIYCNNESITLCEELADEKSYDNETAIKEDKSLGAMCRKFIMLFLVSMKNGVINLDIAEKVLISELDTPEKLNTVSRSHRTKVRRLYDIANVLTAIGLIKKVSLPDRNLKKPIFKYTGPEIESTNSSQNTPIHQIYDSPIKMTTPKKHITPLSEQMHINSLINSDFKNLSNISHSVPSTGYSQNTVPRTPLTDGRRYRKRKLFESDTSFPKIRSLPNLDRTRLTEGLDDSLCRVVEMEYEKMNSNNELQEPKPKACTKLFPKFNSDSCLKITNRKTVKPIQVSGEMRSLNHIISISDKGNATTITFENSPPMSQTPIKNKTMQPISLAAIIIANANQILIPHNTSNIKKNHEKVCNNKNQTEVKSVKTIKIPASTAKPQQVAIEKTSNSDTNYVKVPVGQASKLSPGDILEVVQAGETLQLVTIKTSNSFKNR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00316562;
90% Identity
iTF_00316562;
80% Identity
-