Basic Information

Insect: Cheilosia vernalis
Gene Symbol: topi
Assembly: GCA_949126925.1
Location: OX421358.1:28006221-28008770[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 1.4 1.8e+02 3.7 1.7 1 23 245 269 245 269 0.91

2 13 0.084 11 7.6 4.0 1 21 275 295 275 298 0.80

3 13 6.9 8.7e+02 1.5 0.5 1 9 303 311 303 313 0.87

4 13 0.67 84 4.7 3.6 1 13 332 344 332 356 0.78

5 13 3.1e-05 0.0039 18.4 3.9 1 23 362 384 362 384 0.98

6 13 0.005 0.63 11.4 1.1 1 23 390 412 390 412 0.95

7 13 0.00012 0.015 16.6 1.0 1 23 418 440 418 440 0.99

8 13 1.2e-05 0.0015 19.7 2.8 1 23 446 469 446 469 0.92

9 13 9.6e-05 0.012 16.8 2.7 1 23 484 506 484 506 0.98

10 13 5.3e-06 0.00067 20.8 1.8 1 23 511 534 511 534 0.96

11 13 0.00016 0.02 16.1 2.0 1 23 540 562 540 562 0.97

12 13 4e-06 0.0005 21.2 0.3 1 23 567 589 567 589 0.99

13 13 1e-05 0.0013 19.8 1.8 1 23 595 617 595 617 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	1.4	1.8e+02	3.7	1.7	1	23	245	269	245	269	0.91
2	13	0.084	11	7.6	4.0	1	21	275	295	275	298	0.80
3	13	6.9	8.7e+02	1.5	0.5	1	9	303	311	303	313	0.87
4	13	0.67	84	4.7	3.6	1	13	332	344	332	356	0.78
5	13	3.1e-05	0.0039	18.4	3.9	1	23	362	384	362	384	0.98
6	13	0.005	0.63	11.4	1.1	1	23	390	412	390	412	0.95
7	13	0.00012	0.015	16.6	1.0	1	23	418	440	418	440	0.99
8	13	1.2e-05	0.0015	19.7	2.8	1	23	446	469	446	469	0.92
9	13	9.6e-05	0.012	16.8	2.7	1	23	484	506	484	506	0.98
10	13	5.3e-06	0.00067	20.8	1.8	1	23	511	534	511	534	0.96
11	13	0.00016	0.02	16.1	2.0	1	23	540	562	540	562	0.97
12	13	4e-06	0.0005	21.2	0.3	1	23	567	589	567	589	0.99
13	13	1e-05	0.0013	19.8	1.8	1	23	595	617	595	617	0.98

Sequence Information

Coding Sequence: ATGTGCAGTGTGTTTAAATTGGATCTAAACAAATTCAACATAGAAGATGCTTGCAGAATGTGCGGTAAATGCGACGTAATAACGTCCTCAGGTCTTGTAAACATTTTCTCTGCCGACTCGCAGTCTGATGAAAAGAATAAAGTCCTTCGAGAATTTGATTTATGGAAATTAAGCATCTCCGAAGATGATGGACTTCCACAAAAAGTGTGTAAACAATGTTTTGGCAAATTTTCCCTTATCCATAATTTTCGCAAACAGTGCGAAAACATTCAAGTTGCATTCAAAACTCTTTTCTACAAACAACGAAAGTTGCTGCCGAACACAACAAATAAAGTATCTGCACCAATTCAGTCGGTGGAGTTGCTGCCAAAAATCGAAGTACACGATTCTGGGGCAGAGAACGACCACTACCATGATAACGAGGGGTTAGATGAGATTCCGTTTGAAGATGCTGACTGTAAAAGTGTTCAGTACTTTGAATTGGAAACAGCCAAGGACAGTGAGCCTAGTAAAGAAGATACCCTTGTCGAAAAGAAACATGATGACGAAGAGGACGAGCCAACGATTGCCGAATTAAATGAGTTCAACGACGAGGAGTGGAACACACTATCGCCAAAAGAATTGATTCCCAAGTTAGAGTATGACGACGATGAGTCCAGCCTGAGCTCCGATTTGCTAAGCTCAGATGACGAACGCAAGCTAAATCGTAAGACCAAAACGAAGCCCAACGAATTCAAGTGTGAATACTGCAAGAACTTTTGTCTGGAAAATCAGGAAGATCTCGATACGCATGTAAAGGAAATACACTCGACCGATACTCCTTATACATGTTCGCTGTGCACCAAGACGTTCACCAATGCCAAGCAACGAAATTGCCACTTTATGGTCAGTCACAAGTGGAAGTCACATGAGTGTGATGTTTGTCACAAAATGATAAAAGGTGGCAAGCCAGGTCTGAAGAATCATAAGGACAATGTGCACAACAAGTCGAACTTTGAGTGTGATATTTGCAAGAAGAAATTCGAGAACATCTCGCTAAGTCGGTTTCGGTATCATCTGCGATGGCACGACAGTTCAAAGTTGTTCTCCTGTAAGTCTTGTGATAAAACGTTCGTCACACGATATCACATGGAGGAGCACGAGCGGACGCATACCGACGAGAAATCATTCCTCTGCAGCATTTGTGGTCTAGGCTTGCGTTGCAAACAGAACTTGATTTGGCATATGAAGACGCACACCGGAGAAAGAACATATCAATGCACGCAATGCAGCAAAGCCTTCCCAACACCAACAGCTCTAGCGTGCCATATAAAGACGCATAGCAGCGAGAAAAAGCACGAATGCGACATCTGCAACAAGCATTTCAAGACGAAAGGCAGCCTCAAAACGCACATTGGCAATGTACACAAGGTGGACTTCAACGAAGGGACGCCAAACTCCTCGCCACGCTATTGTTGTCAGCTGTGTCCCAGAACATTCATTTTTGAACGTGATCTCATCAAGCATTTAAAAACCCACGAACATCGTCGCCATGTGTGCGATGTTTGCGGTCTGTCCTATATGCAATCTTCCCACTTAAAGAAGCACATGGAGTCCATTCATTTGAACTACAAGCCGCATGTTTGCACTATATGCGGTCATGCTTTCCCATTCGAGTTTAACTTGAAACAACACGAGTTGACCCACAAAGaaaagGAATTCAAATGCGATGTATGCGATAAGGCATTTACTTTGCTGCCATCACTGGTATCGCATCAGAGGACCCACACTGGCGAAAAACCCTACCAATGCCATCTCTGTGAAAGATCGTACGCCAACAGAGGGAATCTTAAAAGTCATGTTGAGAAGCATTTGCTGGAAGCGAAGCAGAACCAGACATTTACGCAAATCGTCTTGCCCGTCATTTCGGGAGCAATCGATATTCCACAACCGTCAACGTTCACTCTCTTTGATATCAGTAGTACTAACGCGGATCAGCAGCAGCTGGTCCACCAACAGCTCGAACACCAACAGATCGACCACCAGCAGATGCACCTTCAGCCGCAACAGCAGCacccgcagcaacagcagctcCCGCAgctccaccaccaccagcagccGCAAGAAGAAGTAGTAGTGTTTaattcactttaa
Protein Sequence: MCSVFKLDLNKFNIEDACRMCGKCDVITSSGLVNIFSADSQSDEKNKVLREFDLWKLSISEDDGLPQKVCKQCFGKFSLIHNFRKQCENIQVAFKTLFYKQRKLLPNTTNKVSAPIQSVELLPKIEVHDSGAENDHYHDNEGLDEIPFEDADCKSVQYFELETAKDSEPSKEDTLVEKKHDDEEDEPTIAELNEFNDEEWNTLSPKELIPKLEYDDDESSLSSDLLSSDDERKLNRKTKTKPNEFKCEYCKNFCLENQEDLDTHVKEIHSTDTPYTCSLCTKTFTNAKQRNCHFMVSHKWKSHECDVCHKMIKGGKPGLKNHKDNVHNKSNFECDICKKKFENISLSRFRYHLRWHDSSKLFSCKSCDKTFVTRYHMEEHERTHTDEKSFLCSICGLGLRCKQNLIWHMKTHTGERTYQCTQCSKAFPTPTALACHIKTHSSEKKHECDICNKHFKTKGSLKTHIGNVHKVDFNEGTPNSSPRYCCQLCPRTFIFERDLIKHLKTHEHRRHVCDVCGLSYMQSSHLKKHMESIHLNYKPHVCTICGHAFPFEFNLKQHELTHKEKEFKCDVCDKAFTLLPSLVSHQRTHTGEKPYQCHLCERSYANRGNLKSHVEKHLLEAKQNQTFTQIVLPVISGAIDIPQPSTFTLFDISSTNADQQQLVHQQLEHQQIDHQQMHLQPQQQHPQQQQLPQLHHHQQPQEEVVVFNSL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00315436;
90% Identity: iTF_00315436;
80% Identity: -