Cscu016393.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Cheilosia scutellata
Gene Symbol
MBD-R2
Assembly
GCA_955612985.1
Location
OY015312.1:119622830-119626471[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.9e-19 2.4e-15 56.6 0.0 3 76 395 466 393 467 0.93

Sequence Information

Coding Sequence
ATGGTTCGTCGCTGTGTAATAGAAGGTTGTGAGTCGAAATCATCTACACCCCAACATCAAGGTGTTACCTTCCACTCATTTCCATTCGATTCTAAAACCCGCGAAGTATGGATAGAAAATTGTCATCTTCCGCCCGACAAAAACATCACAAAAACCATTTTGGTCTGTTCGCGACATTTCCGTCGCGCCGATTTCCAACCCATGAAGAATGGTAAATATCTGCTAAAGAGTGGAAGCACACCATCAGTATTCCCATGGGGCAAAACTGATTCTAGTTCGAGTAGTGTCGCCTCAGCTCCGATTAGTCGTGTCAACAGTGAAGCAGAAGTTGAAGCAGCGACTGCGTCCACAATTGAAGCAACAATTGCACAGATCATGGCCGAAACGGCCGAGTTAAATCGAGCGGCTGGTATTGTGCCCAAGGAATCGAAAAGGAAGACATCACGATCGGACGAGTCATCAATGGAAAGTCCTCGTTCACAGGGAAGTGGTCCGGCAAAGTTAGAACCGCTCACCAATTTTACTACCGGTGTGCGTTTAGATGTTCAAGAGATCAACGGGCAATGGCACGCGGCGAGGATTGTCGAAGTTGATAACGATGACCGTGAAGTACTcataaaattcgaaaaattcGGCAAATCCAAGAGAGCCGAATCAGAGGAGTGGATCCCAATGAACAGCCCTAGGCTGAGAGCGAAAGCATCAGCTAAACCGCCGTTAACCTTTCAGACTGACGAGAAGTGTTTCGCTCGTTGGACTGGATCGAGAAAGTTCCCAGCATACGTGCAGAAAGTCCTGGGCGATGACATGTATGAGGTTTTGTTCGAAGATGGCTTTGTAAAGGTTGTTCGTGCCAACCATATGAGCAAGGTAAAACCATTGCCTGAGAAGATGATGTCACCCTTTCAAGTAGTAAAGGGTAAGAGTCCAAGGAGCACTGCAGCCGATGCAGCTGCAATTATTGAGTCGCCATCTGCCGAAGAGGCGACTTCACCAAAGTCCTCAAAGCGTTCCCCAAAATCGAAGCGGAAGGATTGGCCTTTAATTTCTATGGATACACTTGATTTGCCTTCCCTAAAACTACCAGAAGTCCCAAAAGACGGCGAATGGACATGCCACTGGGTTAACGACCAACCTATAGGAAAGGAGGGTTTTCTTCTTATTGGCGAACACAAAAAGCCCACAGTCATTGTCGATGACTGGCGTTTACCGCCAAACTGGGTCAAACATATGTACCAGCGGTCGAATGTTCTCGGAAAATGGGATGTTATCCTTGTCAATCCATCTGGAAAACGTTTTCGTTCCAAGGCTGATCTCAAGCAGGCTCTAGAAGATGCCGGTCAGGTATACAACCCTGACGTTTATGACTTTAGCATTCACAGGCGACGTGCGAAGGATATCAACGCATATGTCTACACTGTTGATTATACTCCGCCGCCAAGGCCCCCGAGCACTTCATTAACGAGTCCGATAGCCACTACGGTGACTAGTACTCTAACGACTACatctttcacagaaacaccggTGGCCACCGCAGTGCCACCAATAGAGCTAATGACACCACCACCGGCACCGCCGAAAGTTAAGGAGCCTCTCGAGAAGACCAAAGAAGCAAAGGAATCAAAAGCTGCTGAAGGGAAGCAAGAAGTAAAAGAGGAAGTGGATCCTCCACCTGTGCTGCCACCTTTGGAGGATGGCTTTGCCTACATCGGAGGACTCAAAGTTCAAATCATCGACAACCTTTTCCGTTGTCCACAAGAGGGATGCTTCAAAAACTTCCGCAAAGAGAATCATCTACAGATTCACGTGAAACACTATCACCAAGATCTAATCAAgCTCCTTGGCGTGTGCCCCAATATGCAGGATTTGGCCCTGAAGCGTACCATTGGCCACCCAGACGTTGAACCACAACCCAAAAACCAGATCCCCAATCAGCAGTTCTTTGCCAAAATGCACCAGCAGGATCTGCAGCATTCGCGTGCCCATCGCAAGATGAGTGGCACCCCCACAGCCGTAGTGGCGACTATAACGTCTCCAATCCATGCCACGGCAATCGATGAAATTTCCTCAGTGTCATCTGCTCCCGTGTCGGCTGACGAATCAGCCGATTTCAGTTCAAGCAAAGGCAACTCTACCATGGACACATCTATCCTTGGTTCAGACATATCGCTTGTCACCGCTGATACAGTTGTTAAAGTCGAGCAGGTGGAACCGGCTGTTGCTTCATCATCTGTTACGGCTGAGGAGTCAAAAGCGGTTATAGAAACTCCAGCTCTGCCACCAGAGCCAAAGAAAGCTAAAATGTCGCTCATTAAGAAGGCTCTGAACACCGGCGCCAGGAAGAGCAATCGCCAGCGTACTACAAAGAAATATCTAACTGCCAGCACTCCGATTACCCCAGTTCCAGTGCTGGCTTCATCGTTCGACACCAGCTTCGGCGTCAGTGATTTTGAAGACACTCGTCACTCGTTCAACGCCACTCCGGACAAACCCATCGCGTCGACAAAAAAGCAACCAAAACTCCTCCCACCCGTAGCGACTGATCCGGCAAACACTACCGATGGGAACAGCCTCACAGCGAGCAGCTTTCCCGATCCTAGCGAGTCTCCAAAGTACATCAAGGAGAACGGGGAACTTATCAAGATAGTGCGCATGAAGCAAGAGGAGATCATCAATTGTCTTTGCTCCTATGGCGAGGAAGACGGTCTGATGGTCCAGTGCGAACTTTGTCTCTGCTGGCAACATGGCAGTTGCAATGGAATCGACAAAGAAAGCGACGTTCCCGACAAGTACGTCTGTTACATATGCCGCAATCCACAACGAGGTCGAGAATCGCGCAAATACATCCACGACCAGGATTGGATGTACGAGGGTAAGCTGCCAGCTGCCAACTACCACGAAGAGAATCCAATGCATCCAGAGCGCTTTGAGGTTCTAAAGAAAAGCCACACGCTGTCGGGTAATCTCGTTGAACTCAAACGCTTCCTTCACAGTCTCCAAGTGAAAATCAATATCGCCGGCAATAAAGACCATCCGAAGATGTACCTCTGGGAGAAGAGGTGGGACCCATTGCCCAAGGATGTTATCAAGACCGAGGGTGGCAACATCAAGTCAGAGGACATCGAAATGAAAGACATCAGCAAGGAGCAAAAAGCCCCAAAATCGACGATCGAACCGCATATCCCACAGCCCGAGGCACCAATAGATCCGGTCGAGTGCCAGCATCGCTTGCTGGAACACATCAAAGTGCAGCAGAGTTTGGTCATGAATCGGTTGGATAATATCGAAGCTCAAGTCAATGAACTAGAGACATTGGACAACTTGGTGGATTTGAAATCGGCCAACTTGGAAGAGACTAAGGATGTCTTGGCCACGTTCATAAAGGACTTGGAGATAATGAAAACCATCTCGAAAATCAATGCGCTAGCAAACATGAAGAATAACAGTTTGATGATGTTGAAGTag
Protein Sequence
MVRRCVIEGCESKSSTPQHQGVTFHSFPFDSKTREVWIENCHLPPDKNITKTILVCSRHFRRADFQPMKNGKYLLKSGSTPSVFPWGKTDSSSSSVASAPISRVNSEAEVEAATASTIEATIAQIMAETAELNRAAGIVPKESKRKTSRSDESSMESPRSQGSGPAKLEPLTNFTTGVRLDVQEINGQWHAARIVEVDNDDREVLIKFEKFGKSKRAESEEWIPMNSPRLRAKASAKPPLTFQTDEKCFARWTGSRKFPAYVQKVLGDDMYEVLFEDGFVKVVRANHMSKVKPLPEKMMSPFQVVKGKSPRSTAADAAAIIESPSAEEATSPKSSKRSPKSKRKDWPLISMDTLDLPSLKLPEVPKDGEWTCHWVNDQPIGKEGFLLIGEHKKPTVIVDDWRLPPNWVKHMYQRSNVLGKWDVILVNPSGKRFRSKADLKQALEDAGQVYNPDVYDFSIHRRRAKDINAYVYTVDYTPPPRPPSTSLTSPIATTVTSTLTTTSFTETPVATAVPPIELMTPPPAPPKVKEPLEKTKEAKESKAAEGKQEVKEEVDPPPVLPPLEDGFAYIGGLKVQIIDNLFRCPQEGCFKNFRKENHLQIHVKHYHQDLIKLLGVCPNMQDLALKRTIGHPDVEPQPKNQIPNQQFFAKMHQQDLQHSRAHRKMSGTPTAVVATITSPIHATAIDEISSVSSAPVSADESADFSSSKGNSTMDTSILGSDISLVTADTVVKVEQVEPAVASSSVTAEESKAVIETPALPPEPKKAKMSLIKKALNTGARKSNRQRTTKKYLTASTPITPVPVLASSFDTSFGVSDFEDTRHSFNATPDKPIASTKKQPKLLPPVATDPANTTDGNSLTASSFPDPSESPKYIKENGELIKIVRMKQEEIINCLCSYGEEDGLMVQCELCLCWQHGSCNGIDKESDVPDKYVCYICRNPQRGRESRKYIHDQDWMYEGKLPAANYHEENPMHPERFEVLKKSHTLSGNLVELKRFLHSLQVKINIAGNKDHPKMYLWEKRWDPLPKDVIKTEGGNIKSEDIEMKDISKEQKAPKSTIEPHIPQPEAPIDPVECQHRLLEHIKVQQSLVMNRLDNIEAQVNELETLDNLVDLKSANLEETKDVLATFIKDLEIMKTISKINALANMKNNSLMMLK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00724831;
90% Identity
iTF_00313476; iTF_00312650; iTF_00313520; iTF_00315972; iTF_00316011; iTF_00315183; iTF_00315219; iTF_00311853; iTF_00311817; iTF_00311091; iTF_00311054; iTF_00314356; iTF_00314308;
80% Identity
iTF_00312650;