Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0045 51 4.4 0.1 21 43 19 41 12 47 0.70

2 7 0.012 1.3e+02 3.1 0.0 18 44 44 70 40 73 0.85

3 7 0.0012 14 6.2 0.0 21 44 75 98 67 106 0.89

4 7 0.084 9.5e+02 0.4 0.2 21 34 103 116 99 130 0.69

5 7 0.002 22 5.6 0.0 21 51 131 161 123 162 0.83

6 7 0.0019 21 5.6 0.0 21 44 159 182 154 185 0.89

7 7 0.0041 46 4.6 0.1 21 44 187 210 182 219 0.75

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0045	51	4.4	0.1	21	43	19	41	12	47	0.70
2	7	0.012	1.3e+02	3.1	0.0	18	44	44	70	40	73	0.85
3	7	0.0012	14	6.2	0.0	21	44	75	98	67	106	0.89
4	7	0.084	9.5e+02	0.4	0.2	21	34	103	116	99	130	0.69
5	7	0.002	22	5.6	0.0	21	51	131	161	123	162	0.83
6	7	0.0019	21	5.6	0.0	21	44	159	182	154	185	0.89
7	7	0.0041	46	4.6	0.1	21	44	187	210	182	219	0.75

Coding Sequence: ATGAAGTCATTTACGAAGGACAGCAATTTGACGGTGCACATGCGCACACATACTGGTGAAAAACCGTTTACATGCGAAGTTTGCATGAAGTCCTTTACTGCGAGGAACCATTTAACAACACATATGAGAAGGCATACTGGAGAAAAACCGTATTTGTGTGGAGTTTGTAAGAAGTCTTTTACGCAGAATAACAGTTTGACATTGCACATGCGAACGCACACCGGAGAAAAGCCGTATACGTGTGAAGACTGCATGCAATCATTTACGCAGGACAGCAATTTGACGGTGCACATGCGCACACATACTGGTGAAACACCGTATTTGTGTGAAATTTGTATGAAGTCATTTACTGCGAGAAACCATTTGACGATACATATGAGAACGCATACTGGTGAAACACCGTATACATGTGAAGTTTGTATGAAGTCTTTTACAAGTAGTGGCTCATTGACAACACACGTGCGCACGCACACTGTAGAAAAACCGTATACGTGTGAAGACTGCATGCAATCATTTACGCAGGACAGCAATTTGACGGTGCACATGCGCACACATACTGGTGAAAAACCGTTTACATGTAAAGTTTGCATGAAGGCATTTACTGCGAGAAACCATTTAACGACACATATGAGAACGCATACCGGCGAAAAACCGTATAGTGTGAAGTTTGCATGA
Protein Sequence: MKSFTKDSNLTVHMRTHTGEKPFTCEVCMKSFTARNHLTTHMRRHTGEKPYLCGVCKKSFTQNNSLTLHMRTHTGEKPYTCEDCMQSFTQDSNLTVHMRTHTGETPYLCEICMKSFTARNHLTIHMRTHTGETPYTCEVCMKSFTSSGSLTTHVRTHTVEKPYTCEDCMQSFTQDSNLTVHMRTHTGEKPFTCKVCMKAFTARNHLTTHMRTHTGEKPYSVKFA

Sequence clustering based on sequence similarity using MMseqs2