Basic Information

Gene Symbol
RREB1
Assembly
GCA_949152445.1
Location
OX424524.1:13650722-13664734[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.078 9.8 8.2 0.5 1 23 94 117 94 117 0.94
2 11 0.024 2.9 9.8 0.1 1 23 307 329 307 329 0.97
3 11 0.0013 0.16 13.8 0.4 1 23 338 360 338 360 0.99
4 11 0.00078 0.098 14.5 2.0 1 23 366 389 366 389 0.97
5 11 0.0032 0.39 12.6 1.6 1 23 745 768 745 768 0.96
6 11 0.00026 0.033 16.0 1.3 2 23 965 986 964 986 0.97
7 11 0.12 15 7.6 6.5 1 23 992 1015 992 1015 0.97
8 11 0.087 11 8.0 1.3 1 23 1048 1072 1048 1072 0.91
9 11 0.089 11 8.0 0.2 1 23 1093 1116 1093 1116 0.96
10 11 0.024 3 9.8 0.3 2 23 1156 1177 1155 1177 0.92
11 11 0.03 3.7 9.5 5.3 1 23 1183 1205 1183 1205 0.97

Sequence Information

Coding Sequence
ATGCAGGGTGCTGCCAGTGCCCCCGCGCCTCCCGCGGCCGAACCGCCATCTTCACAACAAATCAAAACAGAGGAGGTCATCAGTGAAGCAAAAATCGAGGCCGACGAAGAAATGGACGGCATTCAAATTGAAAAGCAGGAGCTGCGCGTCACTAGGACGACGAGCATCGACAGTGACAACCGATCAGACAGGAGCGAGGAGGAAGACCTGAGGAGAGCACGCAAACGTGCCGCATCCACCTCACCATCTCCCATGCCGATGGACAAAAGAACAGCAAGGTTCGAGTGCCCCAAGTGCCGGCAGCGATTCGACTCGGTCAACGCTTTCGACATCCACCGATTCACTGCGCACAGTGACGACACCAAAACTGGCTTCGACGATCTTACCTTCGTCGATTTCTCAAGCAAAAAGTTCCCTGAAATTGCCAGAGGAGTCTGCGAGAGGAACCCGCACGTGTCAGTGACCGACCAGCGTTACAGATGTGACATGTGCTGCCGAGACTTCCCGTGTGGACAAGCTTTGGACATTCACAGGAAATCGTGCCTCTCCGCCACCCGAATTCCTACCCCTGAAAGAGATCGCAGGGAGGATTTCTTCGCCAAATTAGATCTCAGAAACAGATCCTTTGGCATTCCTGGAACGTTGACTCCACCAATGGACAGATTCACTCCTAAGTTCGATGATAATCATCTTACCAACGGCATCAGACACATCGATGCCGCTCGCGACTTGGCAGATATTCAATCGATATTAAACGTCACGTCAGCTGGCGGCCTCTTAGAGAGGCTCACAGGCACTAGAGTGTCTTTAGAAAGTTCGGTTCTTACCCCTCCGGACACCATTATCAAGGACAGAGATCAAGAGGAAACCCAAGACAACTTCGCAGCAGAGTTCAGAAGAATGAAGCTGCGTGGAGAGTTCCCCTGTAGGTTGTGCCCTGCCAAGTTCCCTAACCTAAGAGCTTTGAAGGGACACAATAGAGTGCACTTGAGCGGAACGGGCCCGGGACCTTATCAGTGTAACATGTGCCCTCATGCCTCTTTAGATAAGGCTGCGTTAGTACGTCACATGCGTACACATAACGGGGACAGGCCGTATGAATGCGCCGTCTGTAATTACGCTTTTACTACCAAAGCCAACTGCGAGCGTCACTTAAGGAATAGACATGCTAAAGTCACAAGAGAAGATGTGAAACGCTCAATAATTTACCATCCGTCTGAGGATCCTAATAATGATGAAGTTAATTCTAAACTAGCAAGGGATGAAGTGAAGAGATCGCTTGCCTTCCACACCCCTGACATTGATAGGCGAAACGAAAGTTCGGGACGCGATACGCCACTTACGCACTTTACTCCAAGTTTCATTACCGATAGACATCCAGTCACTAACTTAACAACTAAACCGTTACCGTTACCATTGCCATTACCTGAGTCACCTCTACCTCTGCCTATCCAAAGAGATGTAGAGCAGCCACAACCTCGAATTAAAGTGAAGGGTATCGGTCAGCTGACGCAAATACCGGAGTTTAGGCCACCAGAAATCTCGTACAAGTCCAACGACATCTCACACGATTCGTACGATGAAGAAGCTCCCGTTGACTTGAGCACCAGTGACAATAATAGTTGTGATGTTCTTGATCTCAGTAAGAAGAAACGTGACACCGATTCTGAGGAGCCTAAGGCTGCACCACGACCTTCGTTCGAGCCCGATGCAGCGAGCGTCGCTGCTTCAGCATACGATAGGACAAGGTTCCTCTTAGCCTCACAAAGACTTTTTGAAAACTCGCTGCCTAAAATCGATCCGGCATTCTATGCCACCCAGCTGTCGCAGCTGTACGCCGGCACAGTTCCTGGCATCCATGGTTTATCTTTGCCACCATCCTTTCCTATCGCCCCTTACTTACTTCAACCTCCGTTTTTTCCTCACCCAACTGATTCTCAGGAACTTGCCGAAATAAAACAGCACATACAGAAAGAAATTATGCGAGGCTTGAGCATGTCTGGTGGCAGACTCGTCCCAAATGACCAAGACAGTCAGCCTAAAATTGAGCCTGAGGAAGAAGAACAGAAACCACCGCCATCGATCTCACCGATACCTTCGCCGCACTCTGAATCTCCACGCCCACCAATGAATAACACTCTCGTCCCTCAAACGGATTCCGTGAAGATGGTAATAAAGAATGGTGTTCTGATGCCCAAGCAGAAACAAAGGAGATACAGAACTGAAAGACCATTTTCCTGTTCTCAATGTTCGGCGCGGTTTACTCTCCGGTCTAACATGGAACGCCACGTTAAGCAACAACATCCTCAGCACTGGAGTGTCAGAAGACCAGCTCCGAGAGCGCCACCACCGTACCCAACACCTGACTCACTGACTGATCGCATGAAATTCGCTTTACTAGCTCGCCACCTTGAAAGGCCCTTGCAACAATCGGATCGCTCGCCTGTGCGACGAGATTCTGATGAAGTAGCCGATAATGAGGAAGATGAAGAAGATACCCTAGTAATAGACGAGGAGCCTGATCAGGAAGACAAGGCGGAAGATCACACCGCGGCGCGCCTTGCAGCCGCTGAAATCCTAATGGCTACGTGCCAACAGGAAATGACTAAGGACTTCGACCTTAAAATCGCTGGGAACTTGATCAACAAGCCTGTTCCTATTATCAATGATAAGACGGAGTCAGGAACAAACTCTATCTCACCGACTCAAGAGCCACTGCATATCCCGGTGGTGCCTACTCGCAGTGACGAGGAAGAAGATGAAGAGGGTCTAGTGGCCTCCACGAGTGAGGGAAATAACTCTGGTAGCGATGAAAATAAATCAAACGACGAAACAGATACAGCTCTACCACCAAAGAAAAAGTCCGCTTACAGCCTAGCACCCAACCGAGTATCGTGTCCCTACTGCCACCGCAAGTTCCCTTGGTCCTCATCGCTCCGTCGCCACGTCCTGACGCACACCGGACAGAAACCATTCAAGTGTCCGCACTGCACACTTCTCTTCACCACCAAGTCGAACTGCGACCGCCATCTATTGAGGAAGCACGGAGGTTCTGCCAGAGCTGTCTTGGCTGAACCAATCCCTGACACGGTAACCCCACCACAAATAATAAACGACGCCAGAGCAGTGCCAGAAAGGCCTTACAAATGCGTGTCTTGTCCTACTAGCACCTTTTCATCCCTTGAAACGCTAAAGAAGCATATGTCGTCCAGACACGGGATTGATTCTCAACCAGACCCTGAAATTGTGGAAGAAACCAATGAAGGTGGTCTAGTGTTTAAATGCCACCTATGTGAAGCGTCATTTGGAGAAAGGAGTGGAGCCCTGTCGCACTTGGCGACGGGACACACGACTGAATATGAGCAGCTGGTCAGCAAGGGTGCCTTGGATGCTGCCAGTGACAGGAGTGAAagcgctgatgatgatgaaaggggaAAGTTTCCTGACCATGCCAACAGAAAGGTGGTCTGCGCATTCTGTATCCGTCGATTCTGGTCAGCTGAGGACCTCCGTCGTCACATGCGGACTCATTCGGGAGAGAGACCATTTGCTTGCGACCTGTGCCGACGTCGCTTTACCCTGAAGCACAGCATGCTGCGACACCGCAAGAAGCACCGCGAAGAAATCACTGATGATGAGGAAGCTTCCCCACCTAATACGCCGCGTGAAGATGCTGTCACTAATGGATATCGCTACCAAGACGAAGACGGCTCAGGCAATGAAATCCCTAGCAAtgtcaacaacaacaactcGCCTCCCTCCGCTCCATATGAAAAGAAGCTCAAACTGGACATGACTTCGCGCAAATACTCTTCCGAGGCCGACGATCCGGAGAACAGCGACCTCATCGGCAAACTGCTCGGAATCCCCGACAAAACCATCAACAAGCTACTCTCCTCCGCAGACGAGGCCGCGAAAATCCTTGGCGTGAATAAATGA
Protein Sequence
MQGAASAPAPPAAEPPSSQQIKTEEVISEAKIEADEEMDGIQIEKQELRVTRTTSIDSDNRSDRSEEEDLRRARKRAASTSPSPMPMDKRTARFECPKCRQRFDSVNAFDIHRFTAHSDDTKTGFDDLTFVDFSSKKFPEIARGVCERNPHVSVTDQRYRCDMCCRDFPCGQALDIHRKSCLSATRIPTPERDRREDFFAKLDLRNRSFGIPGTLTPPMDRFTPKFDDNHLTNGIRHIDAARDLADIQSILNVTSAGGLLERLTGTRVSLESSVLTPPDTIIKDRDQEETQDNFAAEFRRMKLRGEFPCRLCPAKFPNLRALKGHNRVHLSGTGPGPYQCNMCPHASLDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHAKVTREDVKRSIIYHPSEDPNNDEVNSKLARDEVKRSLAFHTPDIDRRNESSGRDTPLTHFTPSFITDRHPVTNLTTKPLPLPLPLPESPLPLPIQRDVEQPQPRIKVKGIGQLTQIPEFRPPEISYKSNDISHDSYDEEAPVDLSTSDNNSCDVLDLSKKKRDTDSEEPKAAPRPSFEPDAASVAASAYDRTRFLLASQRLFENSLPKIDPAFYATQLSQLYAGTVPGIHGLSLPPSFPIAPYLLQPPFFPHPTDSQELAEIKQHIQKEIMRGLSMSGGRLVPNDQDSQPKIEPEEEEQKPPPSISPIPSPHSESPRPPMNNTLVPQTDSVKMVIKNGVLMPKQKQRRYRTERPFSCSQCSARFTLRSNMERHVKQQHPQHWSVRRPAPRAPPPYPTPDSLTDRMKFALLARHLERPLQQSDRSPVRRDSDEVADNEEDEEDTLVIDEEPDQEDKAEDHTAARLAAAEILMATCQQEMTKDFDLKIAGNLINKPVPIINDKTESGTNSISPTQEPLHIPVVPTRSDEEEDEEGLVASTSEGNNSGSDENKSNDETDTALPPKKKSAYSLAPNRVSCPYCHRKFPWSSSLRRHVLTHTGQKPFKCPHCTLLFTTKSNCDRHLLRKHGGSARAVLAEPIPDTVTPPQIINDARAVPERPYKCVSCPTSTFSSLETLKKHMSSRHGIDSQPDPEIVEETNEGGLVFKCHLCEASFGERSGALSHLATGHTTEYEQLVSKGALDAASDRSESADDDERGKFPDHANRKVVCAFCIRRFWSAEDLRRHMRTHSGERPFACDLCRRRFTLKHSMLRHRKKHREEITDDEEASPPNTPREDAVTNGYRYQDEDGSGNEIPSNVNNNNSPPSAPYEKKLKLDMTSRKYSSEADDPENSDLIGKLLGIPDKTINKLLSSADEAAKILGVNK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00961349;
90% Identity
iTF_01533483;
80% Identity
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