Basic Information

Gene Symbol
-
Assembly
GCA_949152445.1
Location
OX424550.1:10620825-10625160[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.4 50 6.0 0.6 6 21 219 234 219 235 0.94
2 13 0.00019 0.024 16.4 0.7 2 23 261 282 260 283 0.94
3 13 0.021 2.6 10.0 4.3 1 23 295 317 295 317 0.97
4 13 4.7e-05 0.0059 18.3 3.4 1 23 328 350 328 350 0.99
5 13 0.00015 0.019 16.7 1.9 1 23 358 381 358 381 0.96
6 13 0.011 1.4 10.8 0.1 2 23 388 409 387 409 0.95
7 13 0.0086 1.1 11.2 5.1 1 23 415 437 415 437 0.98
8 13 3.6e-07 4.5e-05 25.0 1.2 1 23 443 465 443 465 0.96
9 13 2.8e-05 0.0035 19.0 0.8 1 23 471 493 471 493 0.98
10 13 1.2e-06 0.00015 23.4 0.2 1 23 499 521 499 521 0.98
11 13 0.00027 0.034 15.9 0.3 1 23 527 549 527 549 0.96
12 13 4.7e-05 0.0058 18.3 2.2 1 21 555 575 555 577 0.96
13 13 2.4e-06 0.0003 22.4 0.6 1 23 583 605 583 605 0.98

Sequence Information

Coding Sequence
atggaaATAAGTGCTCAGACATTCGACAGAATATGCCGCGTCTGTTTAATAGAATGTGCCGACATGAAGTCTCTATTTACAAAAATGGACGGCGAAAAACGCAACTTGTTCGAAATACTTGCATTTACTGCTgatattaatgttaaattaaagGATAGTCTGCCAAAACAGGTTTGCGGTGAATGTGAGTCGGTCATGTGCAAAGCTGATGCATTTAAGCGCCGCTGTCTTAATTCTGAGACGATTCTAAACAACATCTACCAAAGCTCTTTGAACCGTGGTGAAACATCGAGTATTGACAGAAAATGCTCGATAAAAGATGAAAATAGGGATATAACtgaaaaattaagcaattataTTAGTTTTGAGACTTCAAGTGTTACTAATTACAGTTGCGAGGACAGTTTTGATAAGAAAAATGTGATTATACAAGATCCTGCATTATTTCCAAACGCTGACGCTAGTTTTTGTAAGCTCACTGACTCTGCAGTACCTGAAGACCTCGGACAACCTGTCAAAGAAGAGATAAGCCTGAATTTTGATGATGAAATCACCTTTCCTGATCACTACGATGATGACAGACCGTGTGACACATTACCTATAGAATTTAAAGAGGAAGAACCTTTACAAACAGCAAAGAAATACACATGTTGCTGTAGACTAACATTTACTACTAAAGATAAGTATAAAAGCCATTTAAAGCAAGAAAACTGTAAtaagtacaaaaagattttagaaaaagttaataaaagcaAATTAGTTGCCataaaaaatgaaatagaatGCGTTGAATGTAATAAGAAGTTCAAAACTCCAAATGCCTGGAGCATACACCAAGAAACCCATCATAATGAACACTTATCCGAAAGCAAATCCCTATTGCATGTTTGCAAATTCTGCTTATGTCAGTTCAAAACGGAGGCAGCATTAAAAACTCACATACTAAAACACGAAAAAACCGTAAACAGCAAAACAGAATCGTACCAATGCTCGTTCTGTTTACgaaaattcaaaaacaaaacttcgCTAACCGCTCATCTACAGCGCCATGAAGAAACGGACAACATAAAACACATTTGCAAAGTATGTAAACGAGAATTTAAATACAAAGCTTATTTAGAAAACCATGTTTTAACGATGCATTCAAGAAAAAATGGTATAAGTTGTGAGGTTTGTGCCCAAAGTTTTCCTAACGAAGAGAGTTTAGAATTGCATAAAGACAGTCACAAAAATGAGAAAAAGCACCGTTGCACGGTTTGCAATAAAGCTTTTCTGATGTTGTGTACGCTGAAGGAGCATATGCGGACACATACTGGTGAGAAACCGTTCTTGTGCTCGCAATGCGGACGAGGGTTTAGTCAGAAGACTAATTTAGCACAGCATATGAGAAGACATCAGGGGCTGAAGCCTTTTAAGTGTGAGAACTGTGAAAAGAGATTCGTATCAAAAGGCGAACTCGATGCTCACAACAGAAAACACAGCGGAGCGCACCCTTTTGTCTGTGACGACTGCGGCAATGGCTTCACGACCTCAAGCGCCCTAGTGAAACACCGCCGCATACACACCGGGGAAAAACCTTACCTTTGTGACCTCTGTCCAATGAGGTTTGCTGCATCAGGGACTTTGAAGAACCATAGACGAACCCACACCGGTGAACGACCCTTCCAATGTTCTTATTGTGAAAAAGCCTTCGTCCAACGCAACGATTTGATCTCCCACATCCGATGCCACACTGGAGAAAAGCCTTATATTTGTACTCAATGTGGTCAGTCGTTCAGAAAAGCTTCTGGATTGAAGAGTCATGTCAAAATGCATGTCAAGGAGCCAGGGAACTTGCTGCAAGGTGTCAGTGTGATGTTGAATGGGGTGCAGTGTGCGGAACAGTGA
Protein Sequence
MEISAQTFDRICRVCLIECADMKSLFTKMDGEKRNLFEILAFTADINVKLKDSLPKQVCGECESVMCKADAFKRRCLNSETILNNIYQSSLNRGETSSIDRKCSIKDENRDITEKLSNYISFETSSVTNYSCEDSFDKKNVIIQDPALFPNADASFCKLTDSAVPEDLGQPVKEEISLNFDDEITFPDHYDDDRPCDTLPIEFKEEEPLQTAKKYTCCCRLTFTTKDKYKSHLKQENCNKYKKILEKVNKSKLVAIKNEIECVECNKKFKTPNAWSIHQETHHNEHLSESKSLLHVCKFCLCQFKTEAALKTHILKHEKTVNSKTESYQCSFCLRKFKNKTSLTAHLQRHEETDNIKHICKVCKREFKYKAYLENHVLTMHSRKNGISCEVCAQSFPNEESLELHKDSHKNEKKHRCTVCNKAFLMLCTLKEHMRTHTGEKPFLCSQCGRGFSQKTNLAQHMRRHQGLKPFKCENCEKRFVSKGELDAHNRKHSGAHPFVCDDCGNGFTTSSALVKHRRIHTGEKPYLCDLCPMRFAASGTLKNHRRTHTGERPFQCSYCEKAFVQRNDLISHIRCHTGEKPYICTQCGQSFRKASGLKSHVKMHVKEPGNLLQGVSVMLNGVQCAEQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00041986;
90% Identity
iTF_00301422;
80% Identity
-