Cleu021677.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Cerastis leucographa
Gene Symbol
Poxn
Assembly
GCA_963082945.1
Location
OY720369.1:8614219-8618161[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 4.1e-20 1.4e-16 61.8 0.1 74 125 19 70 15 70 0.97

Sequence Information

Coding Sequence
ATGGCTGAAGGAAAAAGAAAAGCAAAATCATTTAGAAGAATTTTGATTGTACAGCAAGTCGCAACCCCGACAGTCGTCAAGAAGATTCTGCGGTTAAAACAAGAGAACCCCGGTATGTTCGCTTGGGAGATTCGCGAGAGGCTCCTGAGCGCTAGAGTGTGTGAGCCACACTCCATACCCTCGGTGTCTAGTGTGAACCGGATTCTCAGGAACAGTGGACTGGCTTGGAGTGATGATGACACTAGGAGTGCTCATGAGTCATACCCCCAGCCGGATTTACCGCCAAACATGATGGAATACATGTCAATGAAGAATTCTCTACAACCTTCAGGGATACCGTCGCAACCGACTTCCCCGTACTTCGCTCACTCAGCGGTCAGGGTCCCTCCACCACAGCACGCAGATCCAACGCAGCTGTACGACCGACGACTGGCAACATCCTGGCTTCTAGCCAATCAGGTCCAAGCACAAGGCCTTCTGAAACCCTACCCTATCAACCCCTGGCAAAGAATAATGTTGCCATACCATGATTCCAAAAACTTCTCTCCATATGCATTGAATTTACACAACGATCTCCTAAACCGAATAAACCCTGATGAAGTGAAATCAGAAAATTCAGAACATATTTCAGTTGAAACAAGCGACGATAGCACGGACAGGCCAGATGTAGATGAAGACCAGAAATcgcatgaaaaagaaaaaaagaaaaatccgTATTCCATAGAGGAGCTTTTGAAAAAGCCGGATAAGATGGTGAATGTTAATCCGATTGGGTTCCAGAATTTTCTAAGGCAGCCTAGTGGGAGTATGATTGAAAGTAGCCAGGATGTGAGCAACAGGAGTTCACCAGCAAGTTTCTGTTCGGTACAAAGTGGGGTTTCAAATGATTGCTTTTCTGAATCCGCAAGCTCGGAAATTAAGGCGGGGAATTGA
Protein Sequence
MAEGKRKAKSFRRILIVQQVATPTVVKKILRLKQENPGMFAWEIRERLLSARVCEPHSIPSVSSVNRILRNSGLAWSDDDTRSAHESYPQPDLPPNMMEYMSMKNSLQPSGIPSQPTSPYFAHSAVRVPPPQHADPTQLYDRRLATSWLLANQVQAQGLLKPYPINPWQRIMLPYHDSKNFSPYALNLHNDLLNRINPDEVKSENSEHISVETSDDSTDRPDVDEDQKSHEKEKKKNPYSIEELLKKPDKMVNVNPIGFQNFLRQPSGSMIESSQDVSNRSSPASFCSVQSGVSNDCFSESASSEIKAGN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00968001; iTF_01260076; iTF_01152129; iTF_00745666; iTF_01533019; iTF_01439908; iTF_00186150; iTF_00273575; iTF_00425351; iTF_00001148; iTF_01030184; iTF_00375178; iTF_01119306; iTF_00685411; iTF_00711831; iTF_01064635; iTF_00281227; iTF_00042604; iTF_00809092; iTF_00282316; iTF_00907020; iTF_01534796; iTF_01166669; iTF_01264589; iTF_01491911; iTF_01076464; iTF_00171726; iTF_01342190; iTF_00038739; iTF_00036660; iTF_01361592; iTF_01377448; iTF_01527148; iTF_00907854; iTF_01221520; iTF_00000306; iTF_00040789; iTF_00018138; iTF_01285508; iTF_01425037; iTF_00785166; iTF_00783440; iTF_01441019; iTF_01031118; iTF_00851777; iTF_01230546; iTF_00771894; iTF_00952696; iTF_01029241; iTF_00973755; iTF_00951805; iTF_00784366; iTF_00928659; iTF_00831172; iTF_01063726; iTF_00622803; iTF_01085174; iTF_00726332; iTF_00302079; iTF_01075407; iTF_00450088; iTF_00709206; iTF_00667434; iTF_00121412; iTF_00237542; iTF_00147431; iTF_00447113; iTF_01094891; iTF_01093068; iTF_00071410; iTF_00123346; iTF_00445143; iTF_00758135; iTF_00446104; iTF_00924632; iTF_01246872; iTF_00122362; iTF_01192687; iTF_00806705; iTF_00888241; iTF_01026156; iTF_00111634; iTF_01117186; iTF_01028262; iTF_01062770; iTF_00374067; iTF_00810035; iTF_00172885; iTF_01525989; iTF_00677589; iTF_00449079; iTF_00441464; iTF_00823873; iTF_01360587; iTF_00157176; iTF_00822986; iTF_01502062; iTF_00706930; iTF_00404884; iTF_01436061; iTF_01197696; iTF_00637624; iTF_00908818; iTF_00636374; iTF_00850712; iTF_00300172; iTF_01180280; iTF_01179461; iTF_00177082; iTF_01027291; iTF_00363999; iTF_00274400;
90% Identity
iTF_00281227;
80% Identity
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