Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00067 1.8 9.2 0.0 20 43 90 113 82 124 0.88

2 6 0.69 1.8e+03 -0.5 0.1 16 46 143 173 139 177 0.77

3 6 0.54 1.4e+03 -0.1 0.0 21 43 204 226 198 235 0.81

4 6 0.015 38 4.9 0.0 20 46 259 285 252 287 0.89

5 6 0.017 45 4.7 0.0 21 43 288 310 284 317 0.89

6 6 0.0034 8.9 6.9 0.3 24 46 319 341 311 345 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00067	1.8	9.2	0.0	20	43	90	113	82	124	0.88
2	6	0.69	1.8e+03	-0.5	0.1	16	46	143	173	139	177	0.77
3	6	0.54	1.4e+03	-0.1	0.0	21	43	204	226	198	235	0.81
4	6	0.015	38	4.9	0.0	20	46	259	285	252	287	0.89
5	6	0.017	45	4.7	0.0	21	43	288	310	284	317	0.89
6	6	0.0034	8.9	6.9	0.3	24	46	319	341	311	345	0.85

Coding Sequence: ATGGCTGAAATACTGGAGCCCAACAACTCAAGTCGGCTTAAGTTGGAGGCTGAGGAAAGTGAGGATATCAAGATTGAGCCGGAGGATGAGGAAGAGGACGGAGAATCGGATGAATTGGAGGACAAAACAGGTCTGGAGTCTTCCTACTGCGATCTCTGTTCAGAGACGTTCGATTCACAAGAAGAATTTGACGCACATCTAGAAATGCATAAAGAACTGATTAAAATAGAAGATTTCATACAAAGCAAGGCGCAAGACGTAAAGAAAGACCCGGAAAAGCCGTTCGTCTGTCCCGTTTGCTTCAAGGCGTTCGGAAGAAAGAAATACTTGAATCGACATAAAACTTCACACTCCGATACAAAGGCGCACGTTTGCGATTTGTGTTCGAAGGCCTTCATAAAACGTGAATATTTGATGAATCACAAACGAACTACGCACAACAGCAAAAGGGATTTCGCTTGCGACTTGTGCGGCAAACAGTTTCGTAACATCGGTCACCTCAAACAACATAGAAAACTACATTCGAAAGAAGGATTTTTAAAATGCGACGAGTGTGATAAAGAATTTTCAAACTCCACCGCGTTGTCCATTCATAAGAGATATCACAGCGGAGAACGTCCGTTTAGTTGTTCGTTCTGCGGTGATTTATTCACGAATAACGGTTCGTTGAAAAAACACGAAAGAATACACAAAGGCATCAAGGCGTACACGTGTCAAGATTGCGGACGCCTGTTTATGGAATCCAGTCATCTGAAATATCACATGAGAACACATCGCGATGAAAAACCGTTCGATTGTTCGCGTTGCGATAAGAAGTTTAGAGATAATAGCGCCTTGAAGAGGCATTTTCGTCTTCACACTGGCGAGAGACCTTTTAGCTGTGATATGTGCACGCGGAAGTTCACTCAATCGGGACAATTGAAGAAACATCGTTTGACACACACTGGTGAACGACTGTATTCGTGTGATATTTGCCATAAATTTTACGCTCAGTCGTACAGTATGAAGAGACATATGAGGAAAGTTCACGGCAAAGTTGATACCGCTTAG
Protein Sequence: MAEILEPNNSSRLKLEAEESEDIKIEPEDEEEDGESDELEDKTGLESSYCDLCSETFDSQEEFDAHLEMHKELIKIEDFIQSKAQDVKKDPEKPFVCPVCFKAFGRKKYLNRHKTSHSDTKAHVCDLCSKAFIKREYLMNHKRTTHNSKRDFACDLCGKQFRNIGHLKQHRKLHSKEGFLKCDECDKEFSNSTALSIHKRYHSGERPFSCSFCGDLFTNNGSLKKHERIHKGIKAYTCQDCGRLFMESSHLKYHMRTHRDEKPFDCSRCDKKFRDNSALKRHFRLHTGERPFSCDMCTRKFTQSGQLKKHRLTHTGERLYSCDICHKFYAQSYSMKRHMRKVHGKVDTA

Sequence clustering based on sequence similarity using MMseqs2