Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0056 15 6.2 0.1 22 52 158 188 154 188 0.83

2 6 0.0018 4.7 7.8 0.0 21 44 185 208 180 213 0.89

3 6 0.016 43 4.7 0.0 21 46 213 238 209 244 0.85

4 6 2.3e-05 0.062 13.8 0.1 21 52 241 272 237 273 0.93

5 6 0.056 1.5e+02 3.0 0.0 22 48 270 295 268 300 0.85

6 6 0.00059 1.5 9.4 0.2 21 45 297 321 294 327 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0056	15	6.2	0.1	22	52	158	188	154	188	0.83
2	6	0.0018	4.7	7.8	0.0	21	44	185	208	180	213	0.89
3	6	0.016	43	4.7	0.0	21	46	213	238	209	244	0.85
4	6	2.3e-05	0.062	13.8	0.1	21	52	241	272	237	273	0.93
5	6	0.056	1.5e+02	3.0	0.0	22	48	270	295	268	300	0.85
6	6	0.00059	1.5	9.4	0.2	21	45	297	321	294	327	0.88

Coding Sequence: atggatgaaactagtgctagtgtacataatgaatgTGAAGAATATGTAGTGACTGATGAAGACAACAAGGACTTTCtaaagaatgtcactgtgaaacaagaacctgctgaggaggagagtgaaggtgatgttggacatgctgttccttacGGAGATGTTATTGATATAAAATACGAACCCGATATTAAAACCGAAGAATGTGAGACAGATAACTATTCAGGGACTGAAATTGTAACTGATGACTCTTTAATGAAAAAAGAATCAACTGAGGAGAGTggaggtgatgttggacatgctgttccttatggagacattgacaTATATGAACCTGATCTTAAAACAGAATGTGAGAGAATTAGTagagaaaataatttgtattcagtggccagttcatcttcccaaTGTGACAGGAAAATTGTAGTTTCCGAACATGATCAAAACCCAATCGACAATCACGTCGGCAAAAATGATGAACGAAGATATagctgtaatatttgcatgaagacattcagtcaaacCACGGGTCTAAagagacataaacgaattcacgcatgtgaaaaaccttttaagtgtgatatttgcatgaagacatttattCAAGCTTGGAATCTGAAGGCACATACAAgaattcacactggagaaaaGCCTTATGAGTGCAGTATTTGCGAGAAGACCTTCAGCCATGCGACAAACCTTAAGATGCATGAgcgaattcacactggagaaaaacctttgaaatgtaatatttgcaagaagaacTTTACACAAACGTCAAACTTAAACAGGCATAAACAAATCCTCCATGGCGAAAAACCTCTtgagtgtaatgtttgcggGAAGGCATTCAGAGACGCGTCATACTTAAAGACACATGaactaattcacactggagaaaaaccttttacatgtaatatttgcatgaggACATTTCGTCACGCTTCGAGTTTCAACAGACATAAACGTATTCATGATACTAAGaagtga
Protein Sequence: MDETSASVHNECEEYVVTDEDNKDFLKNVTVKQEPAEEESEGDVGHAVPYGDVIDIKYEPDIKTEECETDNYSGTEIVTDDSLMKKESTEESGGDVGHAVPYGDIDIYEPDLKTECERISRENNLYSVASSSSQCDRKIVVSEHDQNPIDNHVGKNDERRYSCNICMKTFSQTTGLKRHKRIHACEKPFKCDICMKTFIQAWNLKAHTRIHTGEKPYECSICEKTFSHATNLKMHERIHTGEKPLKCNICKKNFTQTSNLNRHKQILHGEKPLECNVCGKAFRDASYLKTHELIHTGEKPFTCNICMRTFRHASSFNRHKRIHDTKK

Sequence clustering based on sequence similarity using MMseqs2