Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.006 11 5.6 0.8 6 29 6 29 3 35 0.88

2 4 0.66 1.2e+03 -1.0 1.2 54 68 40 54 31 56 0.78

3 4 2.3e-14 4.1e-11 42.2 3.3 3 64 100 161 98 166 0.94

4 4 0.052 93 2.6 0.0 5 22 251 268 248 274 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.006	11	5.6	0.8	6	29	6	29	3	35	0.88
2	4	0.66	1.2e+03	-1.0	1.2	54	68	40	54	31	56	0.78
3	4	2.3e-14	4.1e-11	42.2	3.3	3	64	100	161	98	166	0.94
4	4	0.052	93	2.6	0.0	5	22	251	268	248	274	0.83

Coding Sequence: atgTCATACGACGCTACCTGGTGTCCCATTTGCGATAAGCAGGTAAGCTCAAAGTGCCGAGACACGAACGAGCTGCTCCAACATATTCGCAAATGTCATTCAGCGAAGTCCAGAGATAATCCAGAATATCAGTGCAGCCTCTGTTATCATAAATTGCATAAATCAAGATCAAGATTaggtttattaaagaataagaTCAATCGATTATCCCACCCTGAACTAATCTCAAGAAATGCATCAATGtcaatgagaaagaaaaaaatattttccaccaAAGTCGAGACGTGGAAATGGCACTCGAGAAGATTACTATGTCCATCGTGCAATCAGGAATCTGCTCCGTTAATTTCCGTAAAGCAGCACAAGTTCACGAGTTCACATCTGGGCGCCCTGTGTCTCTTAGGGTGCTGGCCGCTGTGCTTTATGCCGCTAACGACGAGTCGTGATAAACGGACACGCATGGTGTGTCCAGTGTGCGGTTACGATTACGGCGCACGTGTGGGAAGTAAGTGCAGCTTGTTGCAGGGTTGCGGTAAACAATTGCCAGAAGTAAATCCAGCTATGAGAAAATTTACGGAAAATAAATCCACCACGTGTTTCGGGTATCCCGAGAGGAAATTGCACTTTGAACAGATTCCGGTAAACATGcACAAATACGACATTATGGGAAGTGGATGCAgaagtagaaataattttatttcatccgCACGTAATCCTCAATGTCACCAGCATCAATTTATAGACGGTGAGCAGAGCGAATGTCAATTTTGTAGGAGTCGATCGATACCGAAATTACATAACCATGGAATGGATGGACATTACGATTACGATTATCACATAAACaatgcaaattattattacgacaATTGTAACCAGTAA
Protein Sequence: MSYDATWCPICDKQVSSKCRDTNELLQHIRKCHSAKSRDNPEYQCSLCYHKLHKSRSRLGLLKNKINRLSHPELISRNASMSMRKKKIFSTKVETWKWHSRRLLCPSCNQESAPLISVKQHKFTSSHLGALCLLGCWPLCFMPLTTSRDKRTRMVCPVCGYDYGARVGSKCSLLQGCGKQLPEVNPAMRKFTENKSTTCFGYPERKLHFEQIPVNMHKYDIMGSGCRSRNNFISSARNPQCHQHQFIDGEQSECQFCRSRSIPKLHNHGMDGHYDYDYHINNANYYYDNCNQ

Sequence clustering based on sequence similarity using MMseqs2