Basic Information

Transcription Factor Domain

TF Family: AF-4
Domain: AF-4 domain
PFAM: PF05110
TF Group: Unclassified Structure
Description: This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.0076 1.5e+02 1.5 0.3 3 31 6 34 4 36 0.83

2 3 7.7e-08 0.0015 18.0 12.3 30 154 60 185 51 278 0.55

3 3 6.2e-07 0.012 15.0 3.1 349 381 281 313 249 329 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.0076	1.5e+02	1.5	0.3	3	31	6	34	4	36	0.83
2	3	7.7e-08	0.0015	18.0	12.3	30	154	60	185	51	278	0.55
3	3	6.2e-07	0.012	15.0	3.1	349	381	281	313	249	329	0.83

Coding Sequence: atgtttTGTTTCAGCGTGGACCGGGACCGGCTTCGCGAAAAGGAACGACAGGCCCGGGCGGCTATGTCGGTCCAAGCGGAGCAGGCGGCCGCCCGAGGTGCGCCAGACACACGGCATGGCCACCATCATCACGGCCATCACAACCACGGCCACCACCACGTTGAGCCGGATCCTGCCACCAACGCGCTCTTCCGAGCTCCCGTTAGGGTGAACCCGGACGCCCACGACACGACGACCAAGCAGATCCAGTCGAAGCTTGGCAACTACTCGCTGGTCAAGCACCTGCTGGTGGACGAGCCGAAGCGGTTGTTCGGCATAGAAGGTGTACCAGCCTCACCAGCGCCGGTGAGCTCGAGTCACAGCCGGCTGCCGTCGTCGCGGAGTTCGCCCTCGACCGGAAGCAACACTACCAGCTCGTCGTCCCAAGAGTTCAAAAAGCCTGGCGGTAGCGGACCGCGTTCATCTTCCTCGACGTCGGTCGCGGCGTcttcgtcctcctcctcgacgTCCTCGTCGGCTCAACGCGGTGGTTTCGTCAAGCCTGCCGACAGTAAGCCTCCACATGGAGGCAGGGGAGGTTACCCCGGACAGCCCGTGAAACacgggagcagcagcaacgagcaTCGTAGTCATGGACTGATACCCGCCAAAGGCCCGCCTCCTGGTTCATCTTCCTCAGGAGGCATGGGCAGCAATAGTGGAGGAACTGCTGCTGGACAATCGTCGTCGAGTCTTATGGGAGGCAGCAGTGCTAATATGCAGAGACAGATGCATACCGCCAGTGTCAGACTGCCCAAGCTGAGCTTCGACGGTGGAAGCTCCAAGTTCAGCACACCCGAGCTCGAGCACATTCTGAAGgaAATGACCCAGCCACCGACGCCTCTGACCGCGATTGCCCAGACGCCTAGGAAAGAGTTGGAGTCCAAGTTCACCTTCAATCCCGTTCTCGCCAAGctAACGGAAGTTGTTCCAGAGCCAGTGAAGCCACCTTGTGCGAAAGTTTCGTCGAAGGTCAGAGCTATTTGA
Protein Sequence: MFCFSVDRDRLREKERQARAAMSVQAEQAAARGAPDTRHGHHHHGHHNHGHHHVEPDPATNALFRAPVRVNPDAHDTTTKQIQSKLGNYSLVKHLLVDEPKRLFGIEGVPASPAPVSSSHSRLPSSRSSPSTGSNTTSSSSQEFKKPGGSGPRSSSSTSVAASSSSSSTSSSAQRGGFVKPADSKPPHGGRGGYPGQPVKHGSSSNEHRSHGLIPAKGPPPGSSSSGGMGSNSGGTAAGQSSSSLMGGSSANMQRQMHTASVRLPKLSFDGGSSKFSTPELEHILKEMTQPPTPLTAIAQTPRKELESKFTFNPVLAKLTEVVPEPVKPPCAKVSSKVRAI

Sequence clustering based on sequence similarity using MMseqs2