Basic Information

Gene Symbol
topi
Assembly
GCA_963556745.1
Location
OY750785.1:7303252-7306451[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 9.1e-06 0.00066 20.5 0.2 2 21 106 125 105 126 0.95
2 17 0.75 54 5.0 0.2 1 23 157 180 157 180 0.95
3 17 0.00017 0.012 16.5 0.3 1 19 185 203 185 205 0.96
4 17 0.7 51 5.1 4.3 1 20 210 229 210 231 0.90
5 17 0.00039 0.028 15.3 0.2 1 23 244 267 244 267 0.95
6 17 7.5e-05 0.0054 17.6 1.0 1 23 273 295 273 295 0.98
7 17 1.6 1.2e+02 4.0 0.4 1 23 329 352 329 352 0.87
8 17 0.001 0.074 14.0 1.8 2 21 480 499 479 500 0.93
9 17 2.4 1.7e+02 3.4 0.1 3 23 507 528 507 528 0.95
10 17 0.023 1.7 9.8 1.7 1 23 533 556 533 556 0.94
11 17 3.7e-05 0.0027 18.6 0.2 2 23 562 583 561 583 0.96
12 17 0.75 54 5.0 0.9 2 20 587 605 587 607 0.91
13 17 0.00021 0.015 16.2 0.3 1 23 633 656 633 656 0.95
14 17 0.00029 0.021 15.7 0.7 1 23 662 684 662 684 0.93
15 17 0.051 3.7 8.7 0.1 1 23 690 712 690 712 0.98
16 17 0.0078 0.57 11.3 0.1 1 23 718 741 718 741 0.94
17 17 0.00098 0.071 14.1 1.5 3 23 749 770 747 770 0.95

Sequence Information

Coding Sequence
ATGACATGGTTTCAGGTGGAGTTTGACGGGGGCTTGCCACAAGGACTGTGCACATTGTGCTCAGAGAGCGCCATCGCCGCTATAAACTTCCGACAGCTTTGCAAGGAGTCCAACAACCAGTGGAAGCAAGTCACCTCCATTGTGGACAATATTGCTCCCCCGTCGAAAGAAGATGCCACCTATTACATATTCTACAATACCGATGATGGCTCAAATCCGACAGTGAAAGTTGTAAAAAAGCGGCCCGCTTCAGTCGAACCTATCTTATTAGTAGAAATGAAGCCAGCGAAAATGGCTCGCCTGTTATCTTCAATGCAATGTCCTGATTGCGGCAAACAATTTCCCAGTCCCGTTCATTTAAACTCCCATTTGAAGAACTCAGTGAAAAGAGCGTGCGAGTTATGTGGTCTCCTTTTTGACAAGCCAAAGTTTCCACAACACTTGCATAAGGCTCACAACAAGATTGTGTATCCCTGCAACCCCTGTCATCAAATATTTGAGGACGAGCTTTCTTTGGATTTACACTTGCTAAAAGCGCATGGGAAGAATTCTCATGAATGTAAAGTGTGCGGAAAAGGTTTCAGCAATGAAAGAGCTCTCACAGCACATTCGTACTGTCACTCACTATTCCTCTGCACATCATGCGGCCGAACTTTCGAGAACCGGAATTGTTACATGTACCATCGCCACCAATGTCAGCCAGAAACTCCTAGTTCAGAAACCAACGAATACATCTGTGACGTTTGTGGCAACTCCTACACTAAAAAGCCTTCCTTGAGGATTCATATAATCCAGAAGCATTTAAACGTCCTACCGTATGTTTGCGAAACATGTGGTAAACGAACCTCAACCATAGCCCATTTACGATCGCACGAAAAAGTGCATACACTTCATAGGAGAACGTTCAATTGTCATTGCGGAGCTGTAATGCGAACAGAATTAGGTTATCAGTTGCATTTACGTAACCATACTGGAGAAAAGCCATATGAATGCGATGAGTGCGGGGATAAGTTTCTGTCAGCTTCTAGACGGCTGGATCATATTAAACGTAGGCATAGGCCTACTAAAGATATGCCGCATGGCTGCAAAGAGTGTTCCGCGCGTTTCattGAAGAAGAGAAATACTGCCCGAAAGGAGCATGCGTGGCGTGCGCGTCGGCTGCTATGGCTGCGCAAGAATTCCGAGTATTCGTTCGCAACTCGCAAAGCATGTGGCATAAAGCAATAAATGCTCTCAATGAAGTGCCAAAATCCTACGGGCCTTCAGTCAAATCTCTATGCTCATTTGTAAAACCAGACAACTTTCAAACCCACACAGTTAAAGACTACACTGGGGGTGACTCAAAACAAATACTCAACAGATTAAGAACCCGCCTAACTAAAAGGAAGTCTGAAATCGAAAAGAAAGCCAGGACTCCACGGTCCGGGCCGGCCTGCAACTGTCCCGACTGTGACAAAAACTTTTTCAGTCCGTACTTTTTGCGTATGCACTTAAAAAATAGTGGATTCAAAGAAGGTTGCTTGCATTGCGGTGCGGTTTTGGCAAGAGGCGATGAAATTAAGGAGCATCTTTCTAAAGTTCACGGCGAAATGTTGTTTCTTTGCAAGAGATGCCCGATGTTGTTCACGAGCGAAATGAAGTTAAAGAAGCACAGTCGAAAAGCTCATAAACCTGGCGCTTGGACCTGTAATGACTGCGGACGATCTTTCCCGGGTAAGACGTCGCTTGAGGTGCACTCGCAAATGCACGCAGTTAGGACATGTAGGGCTTGTGGTGCGCAGTTCACGAACCGTGGTTGTTATAGGGAGCACAGGGCTCGGTGTGAACCGGACGCACGCCCAGATAGACATTCCCTCCCGCGTAACAAAAGATCGAACATTCGAGATCCCGCCACTTTCACATGCGATTACTGTGGCAAAACTTACCTTTCACGACCCCAACTTAAAAACCATATAATTTGGATACATATGGATGTTAGGCCGCACCAATGTCAGTGGTGTGGAAAAAGATTTTATACCCCATCTCGATTAGCGGAACATTCGGTCGTTCATACGCGGGAAAGGAATTACGAATGCGACATTTGTGGCGCGAAATTGGTGTCTAAAATGGCGGCTGTTTATCACAGACGAAGGCATACTGGAGAAAAGCCTTATGTGTGTGAAGATTGCGGCGAAGGTTTCATATCGGCATCAAGGAGGTCGGAACACGCGAAAAGGAGGCATGGGAGAGgacaaaaaatacattgtttgcAGTGCACATCTACTTTTGTTAGAAAATATGAGCTTATAAAACACATGGAAAAGGCACATAGGACTCAAGGACAGAACACAGTAGTCATAGATAAAGAAGACCAGGTTAGCTACGAaattgtaggtatttaa
Protein Sequence
MTWFQVEFDGGLPQGLCTLCSESAIAAINFRQLCKESNNQWKQVTSIVDNIAPPSKEDATYYIFYNTDDGSNPTVKVVKKRPASVEPILLVEMKPAKMARLLSSMQCPDCGKQFPSPVHLNSHLKNSVKRACELCGLLFDKPKFPQHLHKAHNKIVYPCNPCHQIFEDELSLDLHLLKAHGKNSHECKVCGKGFSNERALTAHSYCHSLFLCTSCGRTFENRNCYMYHRHQCQPETPSSETNEYICDVCGNSYTKKPSLRIHIIQKHLNVLPYVCETCGKRTSTIAHLRSHEKVHTLHRRTFNCHCGAVMRTELGYQLHLRNHTGEKPYECDECGDKFLSASRRLDHIKRRHRPTKDMPHGCKECSARFIEEEKYCPKGACVACASAAMAAQEFRVFVRNSQSMWHKAINALNEVPKSYGPSVKSLCSFVKPDNFQTHTVKDYTGGDSKQILNRLRTRLTKRKSEIEKKARTPRSGPACNCPDCDKNFFSPYFLRMHLKNSGFKEGCLHCGAVLARGDEIKEHLSKVHGEMLFLCKRCPMLFTSEMKLKKHSRKAHKPGAWTCNDCGRSFPGKTSLEVHSQMHAVRTCRACGAQFTNRGCYREHRARCEPDARPDRHSLPRNKRSNIRDPATFTCDYCGKTYLSRPQLKNHIIWIHMDVRPHQCQWCGKRFYTPSRLAEHSVVHTRERNYECDICGAKLVSKMAAVYHRRRHTGEKPYVCEDCGEGFISASRRSEHAKRRHGRGQKIHCLQCTSTFVRKYELIKHMEKAHRTQGQNTVVIDKEDQVSYEIVGI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00035947;
90% Identity
iTF_00035947;
80% Identity
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