Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 3.6e-22 1.8e-18 66.5 0.0 1 65 64 130 64 130 0.93

2 3 2.2 1.1e+04 -3.3 0.0 11 29 136 153 135 154 0.71

3 3 4e-17 2e-13 50.3 0.1 1 61 165 246 165 256 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	3.6e-22	1.8e-18	66.5	0.0	1	65	64	130	64	130	0.93
2	3	2.2	1.1e+04	-3.3	0.0	11	29	136	153	135	154	0.71
3	3	4e-17	2e-13	50.3	0.1	1	61	165	246	165	256	0.91

Coding Sequence: ATGTATGAAAGTGAAAACATTGTCTGCACTCCAAAGCGTTTTGCTCTCACAGAAGTAACTAATTCAGCGAATAATGTGTCGCCAACTGCTAACCTCAAGCTGCTGACTAGTGTCGCGTTACAAGAGAATGAAGTCGTACATTTAAATGCGCTACAATATCCTACACCACCGCCGAGCGCAATACATCGCAAAGAAAAATCGCTACAGATACTATGCGATAGATTCCTCGAACTTTACCCTCTTCATGGAAAAGGTACCGTCGAAATTCAATTAGATTGTACGGCTGCAAGGTTAGGTGTAGAGAAGAGACGAATGTATGACATTATAAACATACTAGAAGCTATGCAATGTGCCGttcataaaagaaaaaacacatATCTCTGGTATGGAGGATCAAGACTGAATGCTTTCTTAAAAATGCTAAAGAAAGAAGGGGAAATCCTTAAATTATCTGACGCTTTACGCGGGAAGGCTCCAAAGCCTCCTGCTCCCAAACATAAAACTCTTGGTGTCATGGCCCAAAGGTTtcttatgttatttttagtagAGTCACCGAACACCCTCATAAATCTTGAAATGGCTGTGAGAGTGCTAATTGACACCTCTAACAAGAACCATACATATCTCTCCCCAGATCAACAGGACAGGCAGCACAAATCAAAAGTCAGAAGACTCTATGACATAGCTAATGTATTCATTTCAGTTGGTCTCATTGAAAAGGTGTCTGGCAattctatattaaaaaaaccagtATTTAAGTATGCAGGGCCTTTTAAAGTCAAGAAGGCTGAAGAAGTGATACTTTATACACCTCCAATTACACCCCTTTTTGAGCAACAAACACCATTCCATGTGTTTGCTGGAAAGTCTAAGCGAAAACTTGAGTTCACCAATCCAAATCCATGCAAGGAATTCAAATTTGATGTTAACACACCAAAAGACACACCATCACACAAGTGGAATGATATCTTACTTGTGGCTAACATGGAACTTACTAAAATGAATTGTGGCAAAATAACTCATTTGTGA
Protein Sequence: MYESENIVCTPKRFALTEVTNSANNVSPTANLKLLTSVALQENEVVHLNALQYPTPPPSAIHRKEKSLQILCDRFLELYPLHGKGTVEIQLDCTAARLGVEKRRMYDIINILEAMQCAVHKRKNTYLWYGGSRLNAFLKMLKKEGEILKLSDALRGKAPKPPAPKHKTLGVMAQRFLMLFLVESPNTLINLEMAVRVLIDTSNKNHTYLSPDQQDRQHKSKVRRLYDIANVFISVGLIEKVSGNSILKKPVFKYAGPFKVKKAEEVILYTPPITPLFEQQTPFHVFAGKSKRKLEFTNPNPCKEFKFDVNTPKDTPSHKWNDILLVANMELTKMNCGKITHL

Sequence clustering based on sequence similarity using MMseqs2