Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.2e-14 1.9e-10 42.0 0.1 8 69 84 144 79 150 0.87

2 2 0.12 2e+03 0.3 0.0 3 24 261 282 259 291 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.2e-14	1.9e-10	42.0	0.1	8	69	84	144	79	150	0.87
2	2	0.12	2e+03	0.3	0.0	3	24	261	282	259	291	0.83

Coding Sequence: ATGGAAGATGATAGAACTGATCAGGAAGATGACTATGATTACGATGGGAGTGACGATATCTTCGCCCCTGAAGTTGTTTGCGTACCCATGTCTGGTGATGTACCTTATCAatTCGGCAAAGATGATTTAAGTACAACGAGCTCTACGCCCTCATTATCTAGTATTTTTGGAGGTGGAAGCAGTAGAAAAAGAACACGAGATAGAGGAGGCATCAAGAAACCGCCTGTTGATTTATCATCCCCACAGTTTCTGAAACCTTTCGAATATGGTTGGAAACGAGAGTTAGTTTTCCGTAGTGTAAGCGATATAGGAACGTCAAAGCGTAATGCTGATATCTATTACTATACACCTAAGGGAAAGAAAGTCAGATCTACTAGAGAAGTTATTGAAAACTTGACTGACGTTGAACTAACTATagataattttacatttttcaaagaACCTATTGGAGTTAATGACCCTGAGAAGGAAATTATTCGGGAAGCTAAAGTACGAGCTGAAAGAgaTCATAGTTCAACACCCCCTCCGGCAAAGAAACCATCACTTCCAAAAACACCGAAGGGTGAGAAAGCTGCAAAAGTAATGTCTCCAAGCCATAGTAACTTAAGTCCTGAACATACTACATCACCACCTAAAGTTGGTATCGCTAATTTTAGCGCTACGCCAAAGATTGTTTTGAAGCCCGTGAAGATTCCTTCAGCAAAGAATAAAAGCTCATCAAAGCCTGTATTTACACCTCCATCAAAAAGTAGCAGTTCtaaagGTTCTACACTTCGAGATCGTGAACGGTATCGGACAAATCTTCTGCCGTTGGATTTTGCCAAAATTCTGGTGACAAGGAAATCCAGGATGGTCCTGAAAACCAAATATAGTTTACCAAGGATGAAGGCAGAAGACCTCGGGACAGACAGTCAGCAGAATTCTCTTCTCCTTTAA
Protein Sequence: MEDDRTDQEDDYDYDGSDDIFAPEVVCVPMSGDVPYQFGKDDLSTTSSTPSLSSIFGGGSSRKRTRDRGGIKKPPVDLSSPQFLKPFEYGWKRELVFRSVSDIGTSKRNADIYYYTPKGKKVRSTREVIENLTDVELTIDNFTFFKEPIGVNDPEKEIIREAKVRAERDHSSTPPPAKKPSLPKTPKGEKAAKVMSPSHSNLSPEHTTSPPKVGIANFSATPKIVLKPVKIPSAKNKSSSKPVFTPPSKSSSSKGSTLRDRERYRTNLLPLDFAKILVTRKSRMVLKTKYSLPRMKAEDLGTDSQQNSLLL

Sequence clustering based on sequence similarity using MMseqs2