Cspo036202.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Catocala sponsa
Gene Symbol
-
Assembly
GCA_963564715.1
Location
OY751351.1:10584510-10585586[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.1e-07 8.1e-05 23.9 0.1 25 67 22 64 14 117 0.79

Sequence Information

Coding Sequence
ATGAAAATAGAGAACACAAGAAAACAGCCCTACAAAATGGATACCACTGCAGATCAAGCCGCTCAAGTGATAGCACTACTGCAAACAGGGATGCGACAGTGTAATGTTGCTCGACAACTGAACTTGAGCCGTTTTGCCATTCGTCGAGTGCTCCAACGGTTTCAAGAGACTGGGGGCTACACCCGGAGACAAGGATCAGGAAGACGGCGCTGTACATCTGAGAGAGATGACCGTTTCATTGTGACGACGTCATTGCGGAACCGTTTCTCCAATGCTGTTGAGCTGCAACAGCAGCTCCGTGGGGCTCGTAGAACCGCAGTAAGCACATCTACGATTAGAAGAAGGCTGCGAGAAAGGAGTATTGCGGCCAGAAGACCAGCCAAGGgcccgaaattaacgccacagcATCGTAGAGAGCGATTACAGTTCGCTCGAGAACATCTCAACTGGGATCTTGAACAATGGAGGACCGTACTCTTCTCAGATGAGACGAGAGTATGTCTCTTCGTTAACGATAGGCGAAGGAGAGTGTACAGAAGGCGAAACGAACGGTTTTCTGAAGCTTGCTTGGAGGAGACAGTGGAATATGGAGGGGGATCTTGCATGTTCTGGGGCGGAATTTCAGTCGACGGCAAGACGGAACTCGTTTGCGTATCCCGGACTGGAGGTGCTCGTGGTCAGGGATCACTAACCGCTCATCGGTACATAACCGAGGTGCTGGACATGCATGTAGTCCCATATGCAGGATATGTTGGGGATGGGTTCACTttaatgcacgacaatgctCGTTCCCATACCGCAGTAATCGTGCAGGATTATCTACACGAGGTTGGGATTCCAGTTTTGCAGTGGCCAGCGAGAAGCCCAGACCTGAATCCAATAGAGCATCTCTGGGATGAACTAAAACGACGAGTACGGTTACGTGATCCTGCCCCAGCAACTCTACAAGACCTCCATGATGCTGTAATTGAAGAATGGAATAGGATTCCTCAAGATAGTGTGGTACGGCTGATTGGGTCCATGCAAGAACGAATGGAAGCTGTTATTAGAGCAAGAGTGGGTTGCACTAGGTTTTAA
Protein Sequence
MKIENTRKQPYKMDTTADQAAQVIALLQTGMRQCNVARQLNLSRFAIRRVLQRFQETGGYTRRQGSGRRRCTSERDDRFIVTTSLRNRFSNAVELQQQLRGARRTAVSTSTIRRRLRERSIAARRPAKGPKLTPQHRRERLQFAREHLNWDLEQWRTVLFSDETRVCLFVNDRRRRVYRRRNERFSEACLEETVEYGGGSCMFWGGISVDGKTELVCVSRTGGARGQGSLTAHRYITEVLDMHVVPYAGYVGDGFTLMHDNARSHTAVIVQDYLHEVGIPVLQWPARSPDLNPIEHLWDELKRRVRLRDPAPATLQDLHDAVIEEWNRIPQDSVVRLIGSMQERMEAVIRARVGCTRF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00281281; iTF_00282369; iTF_00281250; iTF_00281282; iTF_00282338; iTF_00281251; iTF_00281283; iTF_00282339; iTF_00281252; iTF_00281284; iTF_00281285; iTF_00821797; iTF_00281254; iTF_00281255; iTF_00281287; iTF_00282343; iTF_00281256; iTF_00282344; iTF_00281257; iTF_00281289; iTF_00282345; iTF_00281258; iTF_00281290; iTF_00282346; iTF_00281259; iTF_00281291; iTF_00282347; iTF_00281260; iTF_00281292; iTF_00282348; iTF_00281261; iTF_00281293; iTF_00282349; iTF_00281262; iTF_00281294; iTF_00282350; iTF_00281263; iTF_00282351; iTF_00281264; iTF_00281296; iTF_00282352; iTF_00281265; iTF_00282353; iTF_00281266; iTF_00281298; iTF_00281235; iTF_00281267; iTF_00281299; iTF_00282323; iTF_00281268; iTF_00281269; iTF_00282357; iTF_00281270; iTF_00281271; iTF_00281272; iTF_00282360; iTF_00281241; iTF_00281273; iTF_00282361; iTF_00281274; iTF_00281275; iTF_00282331; iTF_00281276; iTF_00282332; iTF_00281277; iTF_00282333; iTF_00282365; iTF_00281278; iTF_00282334; iTF_00282366; iTF_00821790; iTF_00281279; iTF_00282335; iTF_00282367; iTF_00281280; iTF_00282336; iTF_00281249; iTF_00282337; iTF_00821793; iTF_00282340; iTF_00821796; iTF_00821794; iTF_00281286; iTF_00282342; iTF_00821798; iTF_00821795; iTF_00282355; iTF_00282354; iTF_00281301; iTF_00821789; iTF_00821792;
90% Identity
iTF_00281281; iTF_00282369; iTF_00281282; iTF_00282338; iTF_00281251; iTF_00281283; iTF_00282339; iTF_00281252; iTF_00281284; iTF_00281285; iTF_00282341; iTF_00821797; iTF_00281254; iTF_00281255; iTF_00281287; iTF_00282343; iTF_00281256; iTF_00282344; iTF_00281257; iTF_00281289; iTF_00282345; iTF_00281258; iTF_00281290; iTF_00282346; iTF_00281259; iTF_00281291; iTF_00282347; iTF_00281260; iTF_00281292; iTF_00282348; iTF_00281261; iTF_00281293; iTF_00282349; iTF_00281262; iTF_00281294; iTF_00282350; iTF_00281263; iTF_00282351; iTF_00281264; iTF_00281296; iTF_00282352; iTF_00281265; iTF_00282353; iTF_00281266; iTF_00281235; iTF_00281267; iTF_00281268; iTF_00281269; iTF_00282357; iTF_00281270; iTF_00281271; iTF_00281272; iTF_00282360; iTF_00281241; iTF_00281273; iTF_00282361; iTF_00281274; iTF_00281275; iTF_00282331; iTF_00281276; iTF_00281277; iTF_00282333; iTF_00282365; iTF_00281278; iTF_00282334; iTF_00282366; iTF_00821790; iTF_00281279; iTF_00282367; iTF_00281280; iTF_00282336; iTF_00282337; iTF_00821793; iTF_00282340; iTF_00821796; iTF_00821794; iTF_00281286; iTF_00282342; iTF_00821798; iTF_00821795; iTF_00281297; iTF_00281250; iTF_00281298; iTF_00281299; iTF_00281248; iTF_00282354; iTF_00282323; iTF_00282355; iTF_00282332;
80% Identity
-