Basic Information

Gene Symbol
TFPT
Assembly
GCA_963675205.1
Location
OY776084.1:24414421-24418833[-]

Transcription Factor Domain

TF Family
HMG
Domain
HMG_box domain
PFAM
PF00505
TF Group
Other Alpha-Helix Group
Description
High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms, and can be broadly divided into two groups, based on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif, while the latter can contain multiple HMG-box motifs. HMG-box domains can be found in single or multiple copies in the following protein classes: HMG1 and HMG2 non-histone components of chromatin; SRY (sex determining region Y protein) involved in differential gonadogenesis; the SOX family of transcription factors [1]; sequence-specific LEF1 (lymphoid enhancer binding factor 1) and TCF-1 (T-cell factor 1) involved in regulation of organogenesis and thymocyte differentiation [2]; structure-specific recognition protein SSRP involved in transcription and replication; MTF1 mitochondrial transcription factor; nucleolar transcription factors UBF 1/2 (upstream binding factor) involved in transcription by RNA polymerase I; Abf2 yeast ARS-binding factor [3]; yeast transcription factors lxr1, Rox1, Nhp6b and Spp41; mating type proteins (MAT) involved in the sexual reproduction of fungi [4]; and the YABBY plant-specific transcription factors.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.9 8.1e+03 -0.9 0.1 53 65 54 66 52 69 0.81
2 2 7.2e-18 1.5e-14 55.9 1.4 1 68 140 212 140 213 0.91

Sequence Information

Coding Sequence
atgacagtCCAACAGATTAACTCGAATATTTCTGACGACTCAGATGATATGGTTAGTTTACCATCTGAAGAGGAAATTTATAGACGAAAATATCAGTTGTTGTTAGAACGATGTGAAGTCTTACAACAGGATAACGAAAGAATTATAAATAGAATTCATGAAGCTAAAAAAATAACCAAGCGCTATCGAAAAGATATCAAGTTGTTGGTTGAAAGGTTGGATAGCCATGGCGATCAGTTTAGAACAGCGTCTTTGGAGGTTGAGACTAAGTCCGAGGTAGTTGTACGACCTCCCCGTGCTGGTGGCAAAACTCAAGCTGTGGCTAAACAGTCAGAAAAGCCCAGTGCTGCAAATGCCAAGAAACCTGGACCTAAAAGGAAAAGTAAAGCAGACAAGCCCGAGAGAGATCCTAATGCTCCAAAAAAGCCTTGTAATGCTTTCTTCCAATTCTGCCAAGAGCAGCGGCCATTAGTAGTAGCTGAAGCCAATTCCGAGATGGGTGCAGAGCCATCCAAACAAGAGGTAACCCGGCAGCTGGCATCGAGATGGAGAGCACTTAACAATGAGGAGAAAAGGGTATATGTTGCAATGTTTGAGagatcaaaagaaaaatatgcagAACAAATGTCAGCCTACATTAAGAAGGAACAATGA
Protein Sequence
MTVQQINSNISDDSDDMVSLPSEEEIYRRKYQLLLERCEVLQQDNERIINRIHEAKKITKRYRKDIKLLVERLDSHGDQFRTASLEVETKSEVVVRPPRAGGKTQAVAKQSEKPSAANAKKPGPKRKSKADKPERDPNAPKKPCNAFFQFCQEQRPLVVAEANSEMGAEPSKQEVTRQLASRWRALNNEEKRVYVAMFERSKEKYAEQMSAYIKKEQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00345809;
90% Identity
iTF_01491937; iTF_00282395; iTF_00869630; iTF_00823042; iTF_01360616; iTF_01502089; iTF_00908846; iTF_00794607; iTF_00157201; iTF_00706962; iTF_00637654; iTF_00677622; iTF_00823897; iTF_00404923; iTF_01152159; iTF_00147459; iTF_01332708; iTF_01441093; iTF_01439937; iTF_00667490; iTF_00177123; iTF_00273603; iTF_00745699; iTF_01061891; iTF_00383653; iTF_01526021; iTF_01028294; iTF_01094918; iTF_01119334; iTF_01363110; iTF_00327080; iTF_00425384; iTF_01425064; iTF_00447145; iTF_00907049; iTF_01118313; iTF_01246985; iTF_00906154; iTF_00907882; iTF_01342218; iTF_00924683; iTF_01093099; iTF_00888268; iTF_01084268; iTF_00952717; iTF_01192717; iTF_00111662; iTF_00124270; iTF_01533934; iTF_00622831; iTF_01534832; iTF_00123377; iTF_01532017; iTF_00449106; iTF_01062802; iTF_01063762; iTF_00809139; iTF_00036724; iTF_00375220; iTF_00038773; iTF_00810069; iTF_01029269; iTF_01487701; iTF_01085238; iTF_00037815; iTF_00771927; iTF_00850743; iTF_00711864; iTF_00973784; iTF_01094040; iTF_01361624; iTF_00300217; iTF_00301177; iTF_00726361; iTF_00758170; iTF_00831226; iTF_00851802; iTF_01030234; iTF_00951835; iTF_01230587; iTF_01533051; iTF_00172956; iTF_00364028; iTF_00445180; iTF_01117212; iTF_00122397; iTF_00274429; iTF_01527229; iTF_00120510; iTF_00185310; iTF_01064670; iTF_00302111; iTF_00186176; iTF_00446144; iTF_00685440; iTF_00928704; iTF_01027328; iTF_00039815; iTF_00043500; iTF_00041776; iTF_00040818; iTF_00042633; iTF_01285541; iTF_00786003; iTF_00785206; iTF_01260102; iTF_00374121; iTF_00171755; iTF_00072152; iTF_01362428; iTF_01338761; iTF_01340114; iTF_00932554; iTF_00931407; iTF_00889215; iTF_01031146; iTF_01026186; iTF_00237579; iTF_00821835; iTF_00049903; iTF_00636404; iTF_01166695; iTF_00709236; iTF_00441493; iTF_00001175; iTF_00000334; iTF_00017336; iTF_00018166; iTF_01436088; iTF_01538746; iTF_00783483; iTF_00784394; iTF_01197725; iTF_01377472;
80% Identity
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