Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_014607495.2
Location
CP053177.1:5746835-5764681[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.00033 0.026 15.6 1.1 1 23 327 349 327 349 0.98
2 11 0.049 3.8 8.8 0.3 2 23 357 379 357 379 0.91
3 11 0.12 9.2 7.6 0.5 1 23 383 405 383 405 0.97
4 11 4.9e-05 0.0038 18.2 1.7 1 23 410 433 410 433 0.98
5 11 0.024 1.9 9.8 0.8 1 23 437 460 437 460 0.97
6 11 0.14 11 7.4 0.1 3 21 474 492 473 497 0.89
7 11 0.18 14 7.0 0.1 2 23 537 559 536 559 0.95
8 11 0.0064 0.5 11.6 0.2 2 19 574 591 573 595 0.93
9 11 0.00015 0.012 16.7 0.4 1 23 601 623 601 623 0.98
10 11 0.00011 0.0085 17.1 2.0 1 23 630 652 630 652 0.96
11 11 1.1e-05 0.00085 20.3 3.0 1 23 658 681 658 681 0.97

Sequence Information

Coding Sequence
ATGCGATGCTCAGTTGCCGATTGTGATAATGAAACGGATCATACTAAGTATCCAGGAATAACATTTCATGAGTTCCCACTAGACCCTGTGCTGAGGAAAGAGTGGCTGCATGCATTGGGCAAGGAGTTACTGTTCACGGACGATCTGGGGATCATTTGTTCCGAACACTTCTTGAGGGATGATCTGTATTATACCAAGGAAGATGGCTGGAGAGTGCGTCCTGGGGCCGTGCCTCTTGTTGTTCAGGATACCTCAAACACCTTTGTTGAACAGCAGGGCATCAAATTAGTGGGTGATGATCTACCAAAGGACCTGTGTATAGAGTGTGCACAACGCTTACTCAACTGCAGTAAGTTCCGGAACAAAAGTCTACGAGCGTATCTTATGTTGATGCAAATATCTGGGACCAATGAACCGTTAACACAAGAAAGCATAAACTCTCTGAATCGATATGAAAACCATCTGACAACATGTCTACAAAAAAAGATATTCGAACCTGATCATTTTGATCTAGTAGTTAAATATAAACCGTCAACTATACCCATAGAGAAAATTGAAGTTAAAGTAGAAGAATACCAAGAACCCAGTATCAAAGATGAAGAGAGTAAAAAAGAGGTGTTTATCGATGAATCAGATAAAAAAGACTTCATCAATGAATCTGATGATAATGCTGATGATGGTGGTGATGATGATGTAGATGATGACAATTTCGCAGACTATCTAAATTGCGAAATGGAACAAGAGTCAGACGAGGAACCAATCATAAAAGTGAAGAAGAAAAGAGACGTTAAAGAGAAACAAGTCAGAACGAGACAAACAACAAGAAAAAAGATTAATAAAACGAAAACTAAAAAGGTAGCCAAGAAAAAGGGTATTGAAGATGACCTGTCAATTTTTACAGTGACAGAATTGACAAAAGAAGAACAATTGGCAGATATACAAAAGAGACAAGACAGTGCTAATTATAAAAATGCTATATTTAAATGTACAATGTGTTTTAAAGGATTCATCAATGAAATTGCCTATGAGAAGCATATGACCAGACATACTGACGTGTGCGGTAAAAACGAATGTCCGGTGTGTAAGATACGATACAAGAACCTACGTCTTGTGAGACAACATCTGACTGCCTTCCACACGCAGAGATTTAGCTGTAACGAATGCTCATATGTCGGTATGAACAGACAAAACGCTCGACTTCATCAAAAATGGCACAAGGGGACCGAATACAAATGTCCTCATTGTGGGGAGGTGTTCAATAAATTCACATCATACATGGGCCACATACGTATAAAGCATCCGTCTGACTTTGTTTGTGAACTTTGCGGGTTTTCATACGTCAGCGAAAAGGGGAAGAAACTACATAAGAGGATGACGCATAGACTGGAAAACACAAAGATCCCACCGGACGCTCCATACTGTGAACCGTGCGACGTGAGATTTATATCTGAAGAGGCTTTACAAAGACATCTCAGCGTATCACCGAGACATAACGCTAATAAAGAAAAGAAGGCGCCCAATCACGGCAAGTTCATAAAGAAACCGGATCAGACGATCAAACGGGAAAACGTCGTGAAGAAGATGCGAGGGTACACCGGTCCACCTATACCTTGTGAACAGTGTGGCGTAGAGCTAGAAGACTTAAAGGAGTACACGGTACATTTCCGTAAACAACACGCAGATAAGAACAGAACGTTCTTCCCGTGCAAGCGACCGGTCATGTGTGACGTGTGCGGGAAACTATTCCAGTCTCAGGTGCATCTAAAAGACCACGCGTGGGTCCACACAGACGAGAAGCCCTTCAAATGCGATCTCTGCGGGAAAGCGTTCCGAATGAAGGCCCGTCTGCTCATACACAGCAAAATACATGACGCTGAGAAGAAAACCTTTCCGTGCCAGCAGTGCGGGAAACATTTCTCTACATACGCTAATCGGCAGAAGCATTTAGTTATTCATACAGGGATAAGATCATACGAGTGCGAAATGTGCGGGAAATGCTTCAAGCATGCCAGCGATAAACGGGCACACATCAACTATGTGCATCTCAAGAAACCGTGGCCGAAACGTACGAGAGGGAAAAGGACAGACACATTGATGGAGCATTCAGCACCAAATCTGAACATGGAAGTAGATGAAGACAAGGATATGCACAACCAGTATCGCAGAGCGTTTCTAAACTAG
Protein Sequence
MRCSVADCDNETDHTKYPGITFHEFPLDPVLRKEWLHALGKELLFTDDLGIICSEHFLRDDLYYTKEDGWRVRPGAVPLVVQDTSNTFVEQQGIKLVGDDLPKDLCIECAQRLLNCSKFRNKSLRAYLMLMQISGTNEPLTQESINSLNRYENHLTTCLQKKIFEPDHFDLVVKYKPSTIPIEKIEVKVEEYQEPSIKDEESKKEVFIDESDKKDFINESDDNADDGGDDDVDDDNFADYLNCEMEQESDEEPIIKVKKKRDVKEKQVRTRQTTRKKINKTKTKKVAKKKGIEDDLSIFTVTELTKEEQLADIQKRQDSANYKNAIFKCTMCFKGFINEIAYEKHMTRHTDVCGKNECPVCKIRYKNLRLVRQHLTAFHTQRFSCNECSYVGMNRQNARLHQKWHKGTEYKCPHCGEVFNKFTSYMGHIRIKHPSDFVCELCGFSYVSEKGKKLHKRMTHRLENTKIPPDAPYCEPCDVRFISEEALQRHLSVSPRHNANKEKKAPNHGKFIKKPDQTIKRENVVKKMRGYTGPPIPCEQCGVELEDLKEYTVHFRKQHADKNRTFFPCKRPVMCDVCGKLFQSQVHLKDHAWVHTDEKPFKCDLCGKAFRMKARLLIHSKIHDAEKKTFPCQQCGKHFSTYANRQKHLVIHTGIRSYECEMCGKCFKHASDKRAHINYVHLKKPWPKRTRGKRTDTLMEHSAPNLNMEVDEDKDMHNQYRRAFLN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00276508;
80% Identity
iTF_00276507;