Ckad010745.2
Basic Information
- Insect
- Caradrina kadenii
- Gene Symbol
- PAX6
- Assembly
- GCA_947462355.1
- Location
- OX381691.1:5670520-5681881[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.1e-66 3.3e-63 211.3 0.3 1 118 18 139 18 146 0.96
Sequence Information
- Coding Sequence
- ATGCACAGCGCGGCGATGGGGGGCGGAGCCCTATTCGGGTGCTCCTCAGCTGGGCATAGCGGCATAAACCAACTCGGTGGGGTCTACGTCAACGGCCGGCCGCTGCCCGATTCGACGCGCCAGAAGATCGTGGAGCTGGCGCACTCGGGCGCGCGACCCTGCGACATCAGCCGCATCCTGCAGGTCTCCAACGGCTGCGTCTCCAAGATTCTCGGCAGCTTTGCACGCAGATATTACGAGACGGGATCGATAAAGCCCCGGGCGATTGGAGGATCTAAGCCAAGAGTGGCCACCACGCCGGTGGTCCAGAAGATAGCTGACTACAAGAGGGAGTGCCCGTCGATCTTCGCGTGGGAGATCAGGGATCGTCTGCTGAGTGAAAACGTGTGTAATAACGACAATATACCTAGTGTATTATGTTCCAATATGAAGTCAAAGAGCAACCGCCTTGTTGTCTATAAACCTAAGAAATTAGAGTGA
- Protein Sequence
- MHSAAMGGGALFGCSSAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGSFARRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSENVCNNDNIPSVLCSNMKSKSNRLVVYKPKKLE
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00947857;
- 90% Identity
- iTF_00446102; iTF_00122360; iTF_00840265; iTF_01260073; iTF_00947857; iTF_00323477; iTF_00318065; iTF_01429014; iTF_01402680; iTF_00922843; iTF_00819134; iTF_00325343; iTF_01334809; iTF_01333767; iTF_01173244; iTF_00345779; iTF_01152991; iTF_00971200;
- 80% Identity
- iTF_00840265; iTF_00947857; iTF_00446102;