Basic Information

Gene Symbol
-
Assembly
GCA_932526535.1
Location
OW052117.1:4222938-4232663[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 3.3 5.8e+03 -2.6 0.0 82 108 39 65 28 74 0.76
2 5 7.4 1.3e+04 -3.7 0.1 82 97 138 153 132 173 0.62
3 5 0.00014 0.25 11.5 0.0 18 91 275 349 270 368 0.85
4 5 6.1e-06 0.011 15.9 0.0 17 86 369 438 363 458 0.86
5 5 0.0043 7.5 6.7 0.0 20 58 463 501 450 519 0.86

Sequence Information

Coding Sequence
ATGGCTCCTGACAATTATAATGAGATAAAGGTGTGCAGGGTGTGCCTTGCACTGGATGTCAAAATGTATGATATGAAAGATTCAAAATGGGGTCAGATGTTTCAAAATGTCACCGGATTATTGGCTTGCAACAAGAAGAGCACAACTCACCTCGTTTGTTGGGAATGCGCTGCCCGACTTTCAGCGGCTGCAACATTCAAAGACAAAGCGCTACTAAGCGATGCCTTGCTTAAAGATTTAGTACACATACAACTTAACGACATCCTGACAATAAGAAAAAACTACAGTTATTTAAAATCTACCTTAACTGTTCATAAAATTTTGACATCTTCTGATATTTTAAATGAAGATTCCAAAGAAATAGAAGTACTTTTACATACAGACAAAAATGAAAATGTCAAAGAGACTGCACCAGAAATAAATCAAGTTAAAAAAGAAAATGATAACTTTGAGCTATGGATAGATATACCAATGAAAATTAAAGTAGAAAATGATCCTATAGCTGATAACAGTACGAATATTGAAGAGACAGATCCTATACCTGATAACAATATCAATATAGAAGACAAAAAAGTCTTTTCAGAAACAAATTTAAGTAATGACAGACAAGGTATTGACGATGAAATGAGTAATAATGATGATGACACAGTAATGAATGGTGAAGAAGAAGATAAAAAGCCAGTGATTGATGAAAAAGGTGATGTTGTGGAGAATAGTGAGACCAGTTCTAGTGAAGAAGATTCAGATGGAGAGTCTAGTAGTGATGCTAAAACGAAAATGTGTAATAAGGTTAGGACTAAGAAAGGAAAAGCAAATGTCAGAATCAACGATAAATTAAAAGAAAAAATAATTGAGTTGAAGAAAAACGGGGCCCCTGCTGTTGGCATAGCTAGGGAGACAGGATTGTCGATATCAGCTATTAATGGTTTTTGGGGTCGTTACTGCAAGAGTGGAAACACTTACCGAAAGTCTAACGCAGAGGGGTCGGCAGAAAAGGAGGACAAAACTGAAGCCTCTAGCTCAATTAAGGAACAGAGGTTGCATACAGCGAATATTGACCATAAAACGCGTACAGAAATGAAAAAGAGAATTAGTAAGCATAAAGAGCTTCATGAAGATTTGAAACAACGCATAATAGCGCTCAAGAAGGAAGGAATGTCTAACAGGCGGGTAGCTTGTGTTCTCAAAACTTCCCGTAGTACGGTTCGTAAGTGGTGGGACCGCTGGAGTTATGAAGGTCATATGGATAACTCCTCGGTTCAAGGTCGAAAGAGGAGGAAGACTACTCCTCAAGAAGATCAGCTCATAATAGACCGGGTGATGCAAGAAAAGAGCGTACACACCCCAACTTTAGCGAAGGAATTGGGTGTTTCTACAAGAGTCGATGCGAAGACCAAACAGCAAATAATTTCCATGAAACAAAATGGCGTCTCAGTTACCGAGATAGCTAACCAATTTCGAGTGACACGAACATCTGTATACGAATGGTGGCGACGTTGGTGTCATGATAATAAGATTGACGCGACCAGTGATAATGCTCCAAGTACGGCGACTGTACATGATCAGGATGCATCAGAAGATAGTACAGTGGGATCCACTGTCATATCGTCGTACAAGTCTGTATGGCAGAAATTATCAGATGAAGAGTCTGTTTCTTAG
Protein Sequence
MAPDNYNEIKVCRVCLALDVKMYDMKDSKWGQMFQNVTGLLACNKKSTTHLVCWECAARLSAAATFKDKALLSDALLKDLVHIQLNDILTIRKNYSYLKSTLTVHKILTSSDILNEDSKEIEVLLHTDKNENVKETAPEINQVKKENDNFELWIDIPMKIKVENDPIADNSTNIEETDPIPDNNINIEDKKVFSETNLSNDRQGIDDEMSNNDDDTVMNGEEEDKKPVIDEKGDVVENSETSSSEEDSDGESSSDAKTKMCNKVRTKKGKANVRINDKLKEKIIELKKNGAPAVGIARETGLSISAINGFWGRYCKSGNTYRKSNAEGSAEKEDKTEASSSIKEQRLHTANIDHKTRTEMKKRISKHKELHEDLKQRIIALKKEGMSNRRVACVLKTSRSTVRKWWDRWSYEGHMDNSSVQGRKRRKTTPQEDQLIIDRVMQEKSVHTPTLAKELGVSTRVDAKTKQQIISMKQNGVSVTEIANQFRVTRTSVYEWWRRWCHDNKIDATSDNAPSTATVHDQDASEDSTVGSTVISSYKSVWQKLSDEESVS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-