Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.21 3e+02 2.4 0.2 26 46 91 111 84 117 0.84

2 9 0.0014 2 9.4 0.3 21 45 114 138 110 142 0.90

3 9 1.6e-05 0.023 15.6 0.2 21 46 142 167 138 173 0.86

4 9 0.026 37 5.3 0.2 21 43 170 192 166 197 0.89

5 9 0.0058 8.2 7.4 0.2 21 44 198 221 193 224 0.90

6 9 0.061 87 4.1 0.0 21 45 226 250 223 256 0.80

7 9 3.8 5.3e+03 -1.6 0.1 26 45 259 278 250 285 0.76

8 9 0.056 79 4.3 1.0 27 46 288 307 282 313 0.84

9 9 0.019 26 5.8 0.0 21 45 310 334 306 340 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.21	3e+02	2.4	0.2	26	46	91	111	84	117	0.84
2	9	0.0014	2	9.4	0.3	21	45	114	138	110	142	0.90
3	9	1.6e-05	0.023	15.6	0.2	21	46	142	167	138	173	0.86
4	9	0.026	37	5.3	0.2	21	43	170	192	166	197	0.89
5	9	0.0058	8.2	7.4	0.2	21	44	198	221	193	224	0.90
6	9	0.061	87	4.1	0.0	21	45	226	250	223	256	0.80
7	9	3.8	5.3e+03	-1.6	0.1	26	45	259	278	250	285	0.76
8	9	0.056	79	4.3	1.0	27	46	288	307	282	313	0.84
9	9	0.019	26	5.8	0.0	21	45	310	334	306	340	0.89

Coding Sequence: ATGGATGTCCATCGTTCCGATGACatcacaaataatatttcgatTAAATCGGAAGTCGAATTTGGTTGCCAACATGTTAAAATTGAAGAGTTGGACGACGTGGAAATCAAGCTGGAATCCCTTCATCATGCcattgatattaaagaagaTCCTTTACTAAACGAATCTCTATTGGATGAAGATTGTAAGTTCCCGTTACAAACTCACACCGATCGAAAGCCGTTTGCGTGCAAACTTGGTGATTTTAAACGGTCAGGCAAGAAGCTTCTCGAGTGTActatttgcgattataaatgttcgcAGAAAACAAGTTTGAGAACCcatttacgaactcataccggggaaaaaccgttcgGGTGTACTGTTTGCGAGTATAAATGTTCTAATAATACCAATTTGAGAAGGcatttacgaactcataccggcgagcAGCCGTTCGGGTGCACCGTTTGCGATTACAAATGTTCTCAGAAAACTAATTTGAGAAGGCATTTACGAACTCAcaccggggaaaaaccgttcgAGTGTACcgtttgcgattataaatgttctgaCGATATCAATTTGAGAAGGCATCAGCGgactcataccggcgagagGCCGTTCGAATGTGCAATTTGCGGTTATAAATGTTcccaaaaaacaaatttgagaaACCATTTTTGGACGCAcaccggcgagaaaccattcGACTGTACCGTTTGCGGTTACAAGTCTTCTCGAAAAGGAAACTTGAGAGCGcatttacgaactcataccggcgaaAAACTGTTACAATGCACTGTTTGCGATTATCAATGTTctcacaaatttaatttgagaaTGCATAAACAAACTCACGCCATCACGAAGCGGTTCGAGTGTACTGTTTGTGCTTATAAATGCGCTCAAAGAACCGATTTGAGAAGGcatttacgaactcataccggggaaaaaccgtacGAGTGTACtctttgcgattttaaattttcttataagaataatttgaaaaggcATTTGCGAACTCATACCAGCCACAAACTGGTTCAGTCTGGTGTTTAA
Protein Sequence: MDVHRSDDITNNISIKSEVEFGCQHVKIEELDDVEIKLESLHHAIDIKEDPLLNESLLDEDCKFPLQTHTDRKPFACKLGDFKRSGKKLLECTICDYKCSQKTSLRTHLRTHTGEKPFGCTVCEYKCSNNTNLRRHLRTHTGEQPFGCTVCDYKCSQKTNLRRHLRTHTGEKPFECTVCDYKCSDDINLRRHQRTHTGERPFECAICGYKCSQKTNLRNHFWTHTGEKPFDCTVCGYKSSRKGNLRAHLRTHTGEKLLQCTVCDYQCSHKFNLRMHKQTHAITKRFECTVCAYKCAQRTDLRRHLRTHTGEKPYECTLCDFKFSYKNNLKRHLRTHTSHKLVQSGV

Sequence clustering based on sequence similarity using MMseqs2