Clat026364.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Cantharis lateralis
Gene Symbol
PBRM1
Assembly
GCA_963170105.1
Location
OY720629.1:36089703-36114708[+]

Transcription Factor Domain

TF Family
TEA
Domain
TEA domain
PFAM
PF01285
TF Group
Helix-turn-helix
Description
The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.9 3e+04 -3.8 0.0 31 48 1342 1359 1332 1364 0.72
2 2 1.6e-30 2.5e-26 92.5 0.1 2 66 1701 1767 1700 1769 0.96

Sequence Information

Coding Sequence
ATGAGTAAAAGACGACGTACGAGTTCGATCGCAAGTCGACAAGAGGACGATTCCCTCGACGGATTGGATGCCTCCACCAGTAGTGGCCCTACCATGCGAAAACGTAGTAAAAAACAGGATCCGcTGGAGTTATGTCAACAACTGTACGATACGataagaaattacaaaaaggaaGATGGTACACTTCTTTGTGACTCCTTCATCAGAGTTCCAAAGCGACGACAAGAACCAGGTTACTACGACGTTGTCACTAACCCCATGGACATGTTGAAAGTGCAACAGAAACTTAAAACCGAAGAGTACGAAGACATCAATGACATGCAAAGTGACATCGAGTTAATAGCAACCAACACAAAAGCATTCTACAAACGAAATTCGCAAGAATATCGTGATGCCACGGATCTGCTCGAGTTATTTATTTCGCTCAGACAAAaattatTTGATTCGAAAGACGAAGACGAaccaaaaactaaaattattcttaaagtTGGAAAACTTGCCAGGAAAGCTGCGGTCGTGGCGGAAGCTCGTATTCAAGAATCGGAACAGCTTGATGATGCATCTGAAACGTCGAATCCTGAAGAAGAATCTAACCTAATCGAAGATCTGTTCACTGCAGTTATGACGGCATCTGATGCGGACAACAAACCTCTTCATACTGCGTTTCAGTTACTTCCATCGAAAAAGAAGTATCCCGAGTATTATGATATTATTCCTAATCCTATTGATTTAAAAGCCATTGCAATTAAGATACAAGCAGGCGAATATAGTCACATCAATGACCTCGAGAAGGATTTGTTGACTATGACTCGTAATGCATGCATGTTTAACGAACCCGGTTCTCAAATTTACAAAGATGCAAAAACGTTGAAAAAAGTGATCAgcagcaaaaaaattgaaattgttcatGGAATTTATTCGGGCGCGAAAAGTAGTGAACGAATCCGCAATAAACGCCTTAGAGGCAGCAGCACGCTTTCAGCTGTCACTGCGGCCTTGCCTGATGATGATGATTCTGACATGGAAGACCAAGAAGAAGTGGTGGAAGAGGAGGAGACTGACTCTGCATATGATTACGAGAATCCCCTTTGGCAACTTTTCGAAGCTGTCAAAAGTGTGACTAGTTCAATTGGAGCGCCACTGATTGAACCGTTTTGGAGGTTACCTTCCAGACGTTTTTATCCAGACTactataaagaaataaaaaatcctgTTTCTTTGACCCAAATTAGACGGAAGTTGGTGAACAATTCCTACGGTACGGTAAGCGAAGTGGCCGGAGATTTGACGATCATgtttgaaaatgcaaaaaaatataatttgcccAATTCAAAGTTATATAAAgATGCAGTAAAGCTCCAAAAAGTGATGCAGTTGAAAGTACAAGAACTACTTGATATCGATCAGGACACTGACAGTGATGCCGACATAGAGGAAAAAGAAAAGGTTTTTAAGAAACGTGGTCCAAAACCTAAAACACCTGGCACTGTGATTGTAAGTGCTGGTCGTGGTAGACCACCCAAAGATGGAATACCACTCAAGAAACGACTTCATAATTTGGCCAAGTACATGGTGGATTACGTGtGTGAGGATGGTCGTAAACCTATGTTGGCTTTCATGGAAAAACCGTCGAAGAAGTTGTACCTGAATTACTACGAAGTTATCTCTGAACCTATTGACTTCTTAGACATCGAAGCTAAAATTAGGGCAGAGCAATACATCAATGAAAATGAGCTGGTGAAAGATTTCAAGCTCATGTTTTCGAATTGCCGTCACTACAATGAAGAGAATTCGAATATTTATGAAGATGCAAACTTGTTGGAGAAAGTTTTACTTGAAAAAATCGGAGCGCCTATTCCTCAACCTGAAAAGGAAAAGAAGATCGTTGTACGTAGTTGTAGACCTAGAAAAGTGTTGACTCCCACAGAGAAAAATTGCAAGACTCTATACGACACGATTCGTGATTACAAAGATCCCAAAAGCAGTAGGcaactttctttaatttttatgaagttGCCGTCCAAGTTGGATTATCCTGACTACTATGAAGTAATAAGAAATCCAATCGACATGGAAAAAATAGCTCAGAAGGTCAAAAATAGTTTGTACGAAACTTTGGATGATCTCgtcaatgattttattttgatgtttgaCAACGCCTGCAAGTACAACGAACCCGATTCGAAGATTTACAAAGATGCTTTGGTACTGCAACGAGTTTGCTTACAAACTAAGCTGCAGTTGAAAGATGACGACGATACTGTTCCTGACGTTCCAGCTGCTATTCAAGATTTACTGCTCAATCTTTTCACTACTGTTTACAACCACCAAGATTCAGATGAGCGATGCTATTCCGATTCTATGGCAGAGTTACCGGAACACGACGAAATCGACGGAAAGAAgaTTCGCGCCTTATCGCTTGATTTAATAAAGCGCCGTTTGGACAAAGGTTTATACCGACGTTTAGATACTTTCCAAGAAGACGTGTTTGCTTGTTTGGAGAGAGCTCGCTCGCTATCTCGTTCTGATTCGCAAGTTTTTGAAGACTCGGTGGAGTTGCAATCCTACTTCATCAAACAACGCGACGAATTGTGCAAAAACGGTGAACTGCTCCTTTCTCCTGCTTTCAATTATACCCTCCCCCAATTAACTGCAGACGTTGAATCTCTCAgacaaactaaattaattcgTGAGTCTTTTGAGGACGAAAATGAAACTCGCAGCTCCGACGATTCAATCATAAGAGACTCAAATGCAGGTGAATCGCTGACTTTAAATCAACAGACCTTTAAAGTGGGCGAGTTCGTTTACGTCGATTCGAAAGATAAAGGCGTTGACCCTCACATTCTTCTAATTGAACGGTTGTGGACCAACAATGAAGGTCAGAAAATGTTGTAtggaaattattacttacgACCAATTGAAACCTACCACGTCACCACTCgaaagtttttagaaaaagaagTCTTTAAATCTGACACTCATGTTGCTGTGCCATTAGAAGAAGTGCGAGAGAGATGTTGCATCATGAACATTAAACAGTATTTTACCATGAAACCGGAGTCTTATGACGAGAAAGACGTCTACGTTTGCGAATCACGATACAGCACCAAAACcagaagctttaaaaaaatgaaagttttccCTGAAACTCCAGACATTCTATTGGTTCAACGTGAAGTTCCACTCGAACCCAAACGAGTCATGTCTGTATTTAGAGAGAGGGTGGAAAAGCATAAAGATGAATTGGCCGAACTGCAAGAACAAGAGAAACTTATCGAGAAGGAAAAACCGaatgtGGTTGCATTTTCAAGTATGGAAATTGACGACGGAAATATTTACTATGAACAGTACAATACCATTTGTAGTGGCCTAGTAAAAACCGGTGATTTTGTTTATGTTGCTGCAGATGGTGGACGACAAACAATCGCCCAGATTGACAGCATTTGGGAAACTAAAGAtgGAAAATGTTTCTTTCGAGGCCCTTGGTTTATCACTCCCCCCGAAATTCCACACTCTCCAACAAGAATGTTCTACAAGCAGGAGCTATTCTTATCAAGTTTAGATGACACGAACCCAATTGTCAGTGTGGTAGGAAAATGTTGCGTTCTCGATTACAACGATTACATATCATCTCGAATAACCGAAATCACTGAGAGTGATGTCTACATCTGCAATTCGATGTACGATGAGATAAACCGGCAAGTTCGTAAGTTACCCAGTGATGGTTTGAAGAAATACAACCACAGTACTGCAGTGACGGAGGACGAAATATACTTTTTCCCAAAGTTAATTAATCCACTTAAAGTGGGCAGCGATGTTGCCCAGTTACAATCTGATACCATCAAACCGCAAAGTTCTACTGTAGTTGAAGTTGAGACTTTACCTGTGATTACAAAAATGACTGACATGGAGGTATTAATTGAGGACTCACTAGACGGTGGACCACCATCTGTAGGTTCAGGGGAAATTCCAACCACAGTCGTAACAACAACTAACAACACATTAGCTACACCCACAACATCCAAAAAGAAGTCAAACAAGAATAAAGTAGTGACAGGatacattttatattcacGTGAAGTACGAAAGAACGTGGTAGCGAACAATCCCGAATCAAATTTCGGTGAAATTAGTAGACTAGTAGGTAACGAATGGCGTTCTTTACCTACTAACGAAAGGCAAGTCTATGAAGAGAAGGCGGCTAAAATTAACGAAGAAACTAAAGCTTTGCTTCTAAACGAAGAATGTGCAAGCCCCGGCCCACCTGTCGACCAAatTTATGAATGCTTGTGGGATGGTTGTGATTTTCAGTTTGAAGAAGTGTCTGATTTGATCGAGCACTGCGTGAAAGATAAAGATGGGCAGGGACACGTTCAAAGTTATTTTCAGGCTAATCCCGATTCTGAAATGAATTGCATGTGGCGCACATGCGGTAGAATTAACAAGAAGAATATTCAACCGTTTCCAAATTTGTCCAGATTAATTCGACACGTTCGTGATATGCACATAAATAAGGGCAACGGTAGGAGTGTACCTCCTGCAGATCGAAGCAAGAATTTTGTTGGAGGCCGAACAATGCCAGTGTTGCAACCATGCGTTTCAACAACGGCGGAAATTTTAGCCGCAAATTCTGCACCAGCTGTAGCGGTTACGCAGCCCCAGGAGCCAATGTTCATTTCGATACCTCCGAGACCTCAACGTGTGCTTCATTCCGAAGCGTACATCAAgtACATTGAAGGATTACAAAcagaaaacaaatatatttcgCCATGGGAGAGGACGTTGAATGCTACTCGCGAAAATACTGCTCCTCCGGATGCAGAAAAACTCAACCTGGTTTCGACGTGGCTTGGTAAGACATACGAGCAACAGGACGATGCGTTAAATGCACTATGGGAATTGAGAAACCAATTACTCAGAGATTCTCTTGGAATCGTGAAAgctaataGTAGTGTGGCTACAACCAACACCATTTCTTCGCCGTGGACACCAGTAACGGGCCCGCAGGCCGATAGTAATGGCGCGGGCCCCGacacaaaaaatttggatGTCGGTGACGTCAGTGAGgaTGAAAAGGATATGACCGCAGCTGATGCGGAAGGAGTGTGGAGTCCTGATATAGAGCAGAGTTTTCAAGAAGCTTTGGCAATTTATCCCCCATGTGGGCGACGGAAAATTATACTCTCTGACGAAGGAAAAATGTATGgtAGAAACGAATTAATAGCCCGATATATAAAACTTAGAACAGGAAAAACGCGCACTCGTAAACAAGTCAGCTCGCACATTCAAGTTTTGGCGCGAAGAAAATTAAGAGAGATACAAGCAAAACTTAAAGTTGATCATGCGGCTAAGGAGAAGGCACTACAGACCATGTCCGGCATGTCGAGTGCACAAATAGTTTCTGCTACGACAATGCACAGCAAGTCATCGAGTTTTGGTCTCAATCCTACATCCTATCCTGGACCGcaaTTTTGGCAGCCTGGTTTGCAACCTGGAACGTCACAAGAtgtgAAACCTTTCCAACAAACGCCATATCCTGGTAAACCTGCGACAGCAGTGTCTGCGGGTGAAGTGGGACCACTTCAAGCTCCACCACCTCCTCCGTGGGAGGGCCGTGCTATCGCGACGCACAAACTTCGACTCGTCGAGTTTTCTGCTTTTATGGAACAACACAGGGATGCCGACAATAcgtaccaTAAACACTTGTTCGTTCACATAGGAGGTACAGCAACCTACGCGGATCCTTTACTGGAGGCCGTCGACGTTCGACAAATATACGACAAATTCCCCGAAAAGAAGGGCGGCCTGAAGGAACTGTACGATAAGGGACCTCAGACCGCCTTCTTTTTGGTTAAGTTTTGGGCGGATCTCAATACGAATATTCAAGATGAGGCGGGCGCGTTCTACGGCGTCACGAGCCaATACGAAAGCAATGAAAATATGACCATAACATGTTCCACGAAAGTTTGTTCTTTTGGTAAACAAGTGGTTGAAAAGGTAGAAACAGAGTATGCACATTACGAAAGTGGTAGATTTATATATCGGATCCATCGTAGTCCAATGTGCGAGTACATGATCAATTTTATCCATAAATTGAAACACCTTCCTGAAAAGTACATGATGAATAGcgtattagaaaatttcacaatattacaaAGCATACTCAGAAACACAGCAATGAATATGTTCTGA
Protein Sequence
MSKRRRTSSIASRQEDDSLDGLDASTSSGPTMRKRSKKQDPLELCQQLYDTIRNYKKEDGTLLCDSFIRVPKRRQEPGYYDVVTNPMDMLKVQQKLKTEEYEDINDMQSDIELIATNTKAFYKRNSQEYRDATDLLELFISLRQKLFDSKDEDEPKTKIILKVGKLARKAAVVAEARIQESEQLDDASETSNPEEESNLIEDLFTAVMTASDADNKPLHTAFQLLPSKKKYPEYYDIIPNPIDLKAIAIKIQAGEYSHINDLEKDLLTMTRNACMFNEPGSQIYKDAKTLKKVISSKKIEIVHGIYSGAKSSERIRNKRLRGSSTLSAVTAALPDDDDSDMEDQEEVVEEEETDSAYDYENPLWQLFEAVKSVTSSIGAPLIEPFWRLPSRRFYPDYYKEIKNPVSLTQIRRKLVNNSYGTVSEVAGDLTIMFENAKKYNLPNSKLYKDAVKLQKVMQLKVQELLDIDQDTDSDADIEEKEKVFKKRGPKPKTPGTVIVSAGRGRPPKDGIPLKKRLHNLAKYMVDYVCEDGRKPMLAFMEKPSKKLYLNYYEVISEPIDFLDIEAKIRAEQYINENELVKDFKLMFSNCRHYNEENSNIYEDANLLEKVLLEKIGAPIPQPEKEKKIVVRSCRPRKVLTPTEKNCKTLYDTIRDYKDPKSSRQLSLIFMKLPSKLDYPDYYEVIRNPIDMEKIAQKVKNSLYETLDDLVNDFILMFDNACKYNEPDSKIYKDALVLQRVCLQTKLQLKDDDDTVPDVPAAIQDLLLNLFTTVYNHQDSDERCYSDSMAELPEHDEIDGKKIRALSLDLIKRRLDKGLYRRLDTFQEDVFACLERARSLSRSDSQVFEDSVELQSYFIKQRDELCKNGELLLSPAFNYTLPQLTADVESLRQTKLIRESFEDENETRSSDDSIIRDSNAGESLTLNQQTFKVGEFVYVDSKDKGVDPHILLIERLWTNNEGQKMLYGNYYLRPIETYHVTTRKFLEKEVFKSDTHVAVPLEEVRERCCIMNIKQYFTMKPESYDEKDVYVCESRYSTKTRSFKKMKVFPETPDILLVQREVPLEPKRVMSVFRERVEKHKDELAELQEQEKLIEKEKPNVVAFSSMEIDDGNIYYEQYNTICSGLVKTGDFVYVAADGGRQTIAQIDSIWETKDGKCFFRGPWFITPPEIPHSPTRMFYKQELFLSSLDDTNPIVSVVGKCCVLDYNDYISSRITEITESDVYICNSMYDEINRQVRKLPSDGLKKYNHSTAVTEDEIYFFPKLINPLKVGSDVAQLQSDTIKPQSSTVVEVETLPVITKMTDMEVLIEDSLDGGPPSVGSGEIPTTVVTTTNNTLATPTTSKKKSNKNKVVTGYILYSREVRKNVVANNPESNFGEISRLVGNEWRSLPTNERQVYEEKAAKINEETKALLLNEECASPGPPVDQIYECLWDGCDFQFEEVSDLIEHCVKDKDGQGHVQSYFQANPDSEMNCMWRTCGRINKKNIQPFPNLSRLIRHVRDMHINKGNGRSVPPADRSKNFVGGRTMPVLQPCVSTTAEILAANSAPAVAVTQPQEPMFISIPPRPQRVLHSEAYIKYIEGLQTENKYISPWERTLNATRENTAPPDAEKLNLVSTWLGKTYEQQDDALNALWELRNQLLRDSLGIVKANSSVATTNTISSPWTPVTGPQADSNGAGPDTKNLDVGDVSEDEKDMTAADAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKLKVDHAAKEKALQTMSGMSSAQIVSATTMHSKSSSFGLNPTSYPGPQFWQPGLQPGTSQDVKPFQQTPYPGKPATAVSAGEVGPLQAPPPPPWEGRAIATHKLRLVEFSAFMEQHRDADNTYHKHLFVHIGGTATYADPLLEAVDVRQIYDKFPEKKGGLKELYDKGPQTAFFLVKFWADLNTNIQDEAGAFYGVTSQYESNENMTITCSTKVCSFGKQVVEKVETEYAHYESGRFIYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQSILRNTAMNMF