Basic Information

Insect: Cantharis flavilabris
Gene Symbol: PBRM1
Assembly: GCA_949152465.1
Location: OX424436.1:52916968-52951768[+]

Transcription Factor Domain

TF Family: TEA
Domain: TEA domain
PFAM: PF01285
TF Group: Helix-turn-helix
Description: The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.9 3.9e+04 -3.9 0.0 31 48 1352 1369 1342 1374 0.72

2 2 2.5e-30 3.3e-26 92.5 0.1 2 66 1711 1777 1710 1779 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.9	3.9e+04	-3.9	0.0	31	48	1352	1369	1342	1374	0.72
2	2	2.5e-30	3.3e-26	92.5	0.1	2	66	1711	1777	1710	1779	0.96

Sequence Information

Coding Sequence: ATGAGTAAAAGGCGACGTACGAGTTCGATCGCAAGTCGACAAGAGGATGATTCCCTCGACGGGTTGGATGCCTCCACCAGCAGTGGCCCCACTATGCGAAAACGTAGTAAAAAACAGGATCCGCTGGAATTATGTCAACAACTCTACGATACTATCAGAAACTATAAAAAGGAAGACGGTACGCTTCTGTGTGACTCCTTCATAAGAGTTCCAAAGCGACGACAAGAACCAGGTTACTACGATGTTGTCACTAATCCCATGGATATGTTGAAAGTACAACAGAAACTTAAAACCGAAGAGTACGATGATATCAACGACATGCAAAGTGACATCGAGCTAATTGCAACTAACACGAAAGcattttacaaaagaaattcGCAAGAATATCGTGATGCCACGGATCTGCTCGAGTTATTTTTAACACTCAGACAAAAgtTATTTGATTTGAAAGACGACGACGAACCGAAAACCAAAATAGTTCTTAAAGTTGGAAAACTTGCAAGAAAAGCCGCGGTCGTGGCGGAAGCACGCATTCAAGAATCGGAACAACTTGATGATGCATCTGAAACGTCGAATCCTGAAGATGAATCTAACCTTATTGAGGATCTTTTCACGGCAGTTATGACTGCGTCTGATGCCGACAACAAACCTCTTCACACTGCGTTTCAGTTACTTCCATCGAAAAAGAAGTATCCTGAGTATTACGATATTATCTCGAATCCTATTGATTTAAAAGCCATTGCAATTAAGATACAAGCAGGCGAATATGGTCACATCAATGACCTGGAGAAGGATTTGTTTACTATGACTCGTAATGCGTGTATGTTTAACGAACCCGGTTCTCAAATTTACAAAGATGCAAAAACGTTGAAAAAGGTGATTAGcagcaaaaaaattgaaattgtacaTGGAATTTATTCGGGCGCGAAAAGTAGTGAGCGAATCCGAAATAAACGCCTTAGAGGCAGCAGCACGCTTTCGGCTGTCACTGCAGCCTTACCTGATGACGACTCCGACACGGAAGATCAAGAAGAAGTAATGGAAGAGGAGGAGacTGACTCTGCATATGATTACGAGAATCCTCTTTGGCAACTTTTTGAAGCTGTCAAAAGTGTTACTAGCTCTACTGGAACGCAACTAATCGAACCGTTTTGGAGATTACCTTCGAGGCGCTTTTATCCGGACTATTACAAGGAAATTAAGAATCCTGTTTCTTTGACCCAAATTAGACGGAAGTTGGTGAACAATTCTTATGGTACGGTAAGCGAAGTGGCGGGAGATTTGACCATCAtgtttgaaaatgcaaaaaaatataatttgcccAATTCCAAATTATATAAAGATGCAGTAAAGCTCCAAAAAGTGATGCAGTTGAAAGTACAAGAACTACTTGATATCGATCAGGTAACACACAGAGTCACTAACAAAAATCGAAAGGACACTGACAGTGATGCCGACGTAGAGGAAAaagaaaaggtttttaaaaagcGTGGTCCGAAACCTAAAACACCTGGCACTGTGATTGTAAGTGCCGGCCGGGGTAGACCACCCAAAGACGGAATACCACTCAAGAAACGACTTCATAATTTGGCCAAATACATGGTGGATTATGTGTGTGAGGATGGTCGTAAGCCCATGTTGGCTTTCATGGAAAAACCATCAAAGAAGTTATACCTAAATTACTACGAAGTTATCTCTGAACCTATCGACTTCTTAGACATAGAAGCTAAAATTAGGGCAGAGCaatacatcaatgaaaatgaGCTGGTGAAAGATTTCAAACTCATGTTTTCAAATTGTCGTCACTACAACGAAGAGAATTCGAATATTTATGAAGATGCAAACCTGTTGGAGAAGGttttacttgaaaaaattgGAGCGCCAATTCCTCAACCtgaaaaagaaaagaagaacGTTGTACGTAGTTGTAGACCCAGAAAAGTGCTAACTCCCACCGAGAAAAATTGCAAGACTTTATACGACACGATTCGCGATTACAAGGATCCCAAAAGCAGTAGGCaactttctttaatttttatgaagttaCCATCTAAGCTGGATTATCCTGACTATTACGAAGTGATAAGAAATCCAATCGACATGGAAAAAATAGCTCAGAAGGTCAAAAATAGTTTGTACGAAACTTTGGATGATCTTGTcaatgattttattttgatgttggACAACGCCTGCAAGTACAACGAGCCTGATTCCAAGATTTATAAGGATGCTTTGGTACTGCAACGAGTTTGTTTACAAACTAAGTTGCAGTTGAAAGATGACGACGACACTGTTCCTGACGTTCCAGCTGCTATCCAAGATTTACTGCTCAATCTTTTCACTACTGTCTACAACCACCAAGATTCGGACGAGCGATGCTATTCTGATTCTATGGCAGAGTTACCGGAACACGACGAAATCGACGGAAAGAAGATTCGAGCCTTATCGCTTGATTTAATAAAACGTCGTTTGGACAAAGGTTTGTACCGACGTTTAGACACTTTCCAAGAAGACGTTTTTGCTTGTTTGGAAAGAGCACGCTCGCTATCGCGTTCCGATTCACAAGTTTTTGAAGACTCGGTAGAGCTGCAATCTTACTTCATCAAGCAACGCGACGAGTTGTGCAAAAACGGTGAACTGCTTCTTTCTCCTGCTTTCAATTATACCCTCCCCCAGTTAACCGCAGACGTTGAATCTCTCAGACAAACTAAACTAATTCGTGAATCTTTCGAGGACGAAAATGAAACTCGGAGCTCGGACGATTCGATCATAAGGGATTCAAATTCAGGTGAATCTCTGACTTTAAATCAACAGACGTTTAAAGTGGGCGAGTTTGTTTACGTCGACTCTAAAGATAAGGGCGTTGATCCTCACATTCTGCTAATTGAACGTTTGTGGACCAACAATGAAGGTCAGAAAATGTTGTATGGAAATTATTACTTACGTCCAATTGAAACATATCACGTTACCACTCGAAAGTTTCTAGAAAAGGAAGTTTTCAAATCTGATACTCACGTTGCTGTGCCATTGGAAGAAGTACGAGAGAGATGTTGCATCATGAACATTAAACAGTATTTTAGCATGAAACCCGAGTTATATGACGAGAAAGACGTCTACGTTTGCGAATCTCGATACAGTACCAAAACCaggagttttaaaaaaatgaaagtttttccTGAAACTCCAGACATTCTGTTGGTGCAACGTGAGGTTCCACTAGAACCCAAACGAGTTGTGTCTGTTTTTAGAGAGAGAGTGGAAAAGCATAAGGACGAATTGGCCGAACTGCAAGAACAAGAAAAACTTATCGAGAAGGAAAAACCGaatgtgGTTGCATTTTCGAGTATGGAAATTGATGACGGAAATATTTACTATGAGCAGTACAATACTATTTGCAGTGGTCTAGTGAAAACTGGTGATTTTGTTTATGTTGCTGCAGATGGAGGACGGCAAACGATAGCCCAGATTGACAGCATTTGGGAAACTAAAGAtgGAAAATGTTTCTTTCGGGGCCCATGGTTTATTACCCCACCTGAAATTCCACACTCTCCGACAAGGATGTTTTACAAGCAGGAGCTATTCTTATCAAGTTTAGATGACACGAACCCGATTGTCAGTGTGGTAGGAAAATGTTGCGTTCTCGATTACCAGGATTACATTTCATCTCGAATAACTGAAATCACTGAGAGTGACGTCTACATCTGCAATTCGATGTACGATGAGATGAACCGACAAGTTCGTAAGTTACCCAGTGATGGTTTGAAGAAGTACAACCACAGTAATGCAGTGACGGAGGACGAAATTTACTTTTTCCCAAAGTTAATTAATCCACTTAAAGTGGGCAGCGATGTTGCCCAATTACAATCTGATACCATCAAACCGCAAAGTTCTACTGTAGTTGAAGTTGAGACTTTACCTGTGATTACAAAAATGACTGACATGGAGGTATTAATTGAGGACTCACTAGACGGTGGACCACCATCTGTAGGTTCAGGGGAAATTCCAACCACGGTCGTAACAACAACTAACAACACATTAGCTACACCCACAACATCCAAAAAGAAGTCAAACAAGAATAAAGTAGTGACAGGATACATTTTATATTCACGTGAAGTACGAAAGAACGTGGTAGCGAACAATCCCGAATCAAATTTCGGTGAAATTAGTAGACTAGTAGGTAACGAATGGCGTTCTTTACCTACTAACGAAAGGCAAGTCTACGAAGAGAAAGCTgctaaaattaatgaagaaacTAAGGCTTTACTTCTAAACGAAGAATGTGCAAGCCCCGGCCCACCTGTCGACCAaATTTATGAATGCTTGTGGGATGGCTGTGATTTTCAGTTCGAAGAAGTGTCCGATTTGATCGAGCACTGCGTGAAAGATAAAGATGGCCAGGGACACGTCCAAAGTTACTTTCAGGCTAATCCCGATTCCGAAATGAATTGCATGTGGCGCACTTGTGGTAGAATTAATAAGAAGAACATTCAACCGTTTCCAAATTTGTCCAGATTAATTCGACACGTTCGCGATATGCACATAAATAAGGGCAACGGTAGGAGTGTACCTCCTGCGGATCGAAGCAAGAATTTTGTCGGAGGCCGAACAATGCCAGTGTTGCAACCGTGCGTTTCAACAACGGCGGAAATTTTAGCcgCAAATTCTGCACCAGCTGTAGCGGTTACGCAGCCCCAGGAGCCGATGTTCATTTCGATACCTCCGAGACCTCAACGGGTGCTTCATTCCGAAGCGTACATCAAgtaCATTGAAGGATTGCAAACGGAAAACAAATATATTTCGCCATGGGAGAGGACGTTGAACGCTACCCGCGAAAATACTGCTCCTCCGGATGCAGAAAAGCTCAACCTGGTTTCGACGTGGCTTGGTAAGACGTACGAACAACAGGACGATGCGTTAAATGCATTATGGGAGTTGAGAAATCAATTACTCCGAGATTCGCTTGGAATCGTGAAAGCTAACAGTAGTGTGGCTACAACCAACACCATTTCTTCGCCGTGGACACCAGTAACGGGCCCGCAGGCCGATAGTAATGGCGCGGGCCCCGACACAAAAAATTTGGATGTCGGTGACGTCAGTGAGgaTGAAAAGGATATGACCGCAGCTGATGCGGAAGGAGTGTGGAGTCCTGATATAGAGCAGAGTTTTCAAGAAGCTTTGGCAATTTATCCCCCATGTGGGCGACGGAAAATTATACTCTCTGACGAAGGAAAAATGTATGgTAGAAACGAATTAATAGCCCGATATATAAAACTTAGAACAGGAAAAACGCGCACTCGTAAACAAGTCAGCTCGCACATTCAAGTTTTGGCGcgaagaaaattaagagagataCAAGCAAAACTTAAAGTTGATCATGCGGCTAAGGAGAAGGCACTACAGACCATGTCCGGCATGTCGAGTGCACAAATAGTTTCTGCTACGACAATGCACAGCAAGTCATCGAGTTTTGGTCTCAATCCTACATCCTATCCTGGACCGCAATTTTGGCAACCCGGCTTGCAACCTGGAACGTCACAAGAtgtgaaACCTTTCCAACAAACGCCATATCCTGGTAAACCTGCGACAGCAGTGTCTGCGGGTGAAGTGGGACCACTTCAAGCTCCACCACCTCCTCCGTGGGAGGGCCGTGCTATCGCAACGCACAAACTTCGACTTGTTGAGTTTTCTGCTTTTATGGAACAACACAGGGATGCCGACAATACGtaccaTAAACACTTGTTCGTTCACATAGGAGGTACGGCCACCTATGCGGATCCTTTACTCGAGGCCGTCGATGTTCGACAAATATACGACAAATTCCCCGAAAAGAAAGGCGGCCTGAAGGAACTATACGATAAGGGACCTCAGACCGCTTtctttttggttaaattttggGCGGATCTCAATACGAATATACAAGATGAGGCGGGCGCGTTCTACGGCGTCACGAGCCAATACGAAAGCAATGAAAATATGACCATAACATGTTCCACGAAAGTTTGTTCTTTTGGTAAACAGGTGGTCGAAAAGGTAGAAACAGAGTATGCACATTACGAAAGTGGTAGATTTATATATCGGATCCATCGTAGTCCAATGTGCGAGTACATGATCAATTTTATCCATAAATTGAAACACCTTCCTGAAAAGTACATGATGAATAGCGtattagaaaatttcacaatattACAAGTTGTTAGTAATAGAGAAACGCAAGAAACTCTCTTATGTACAGCGTACGTATTTGAAGTGTCGACATCGGAGCACGGTGCCCAACATCATATCTACAGGCTTGTTAAGGATTAG
Protein Sequence: MSKRRRTSSIASRQEDDSLDGLDASTSSGPTMRKRSKKQDPLELCQQLYDTIRNYKKEDGTLLCDSFIRVPKRRQEPGYYDVVTNPMDMLKVQQKLKTEEYDDINDMQSDIELIATNTKAFYKRNSQEYRDATDLLELFLTLRQKLFDLKDDDEPKTKIVLKVGKLARKAAVVAEARIQESEQLDDASETSNPEDESNLIEDLFTAVMTASDADNKPLHTAFQLLPSKKKYPEYYDIISNPIDLKAIAIKIQAGEYGHINDLEKDLFTMTRNACMFNEPGSQIYKDAKTLKKVISSKKIEIVHGIYSGAKSSERIRNKRLRGSSTLSAVTAALPDDDSDTEDQEEVMEEEETDSAYDYENPLWQLFEAVKSVTSSTGTQLIEPFWRLPSRRFYPDYYKEIKNPVSLTQIRRKLVNNSYGTVSEVAGDLTIMFENAKKYNLPNSKLYKDAVKLQKVMQLKVQELLDIDQVTHRVTNKNRKDTDSDADVEEKEKVFKKRGPKPKTPGTVIVSAGRGRPPKDGIPLKKRLHNLAKYMVDYVCEDGRKPMLAFMEKPSKKLYLNYYEVISEPIDFLDIEAKIRAEQYINENELVKDFKLMFSNCRHYNEENSNIYEDANLLEKVLLEKIGAPIPQPEKEKKNVVRSCRPRKVLTPTEKNCKTLYDTIRDYKDPKSSRQLSLIFMKLPSKLDYPDYYEVIRNPIDMEKIAQKVKNSLYETLDDLVNDFILMLDNACKYNEPDSKIYKDALVLQRVCLQTKLQLKDDDDTVPDVPAAIQDLLLNLFTTVYNHQDSDERCYSDSMAELPEHDEIDGKKIRALSLDLIKRRLDKGLYRRLDTFQEDVFACLERARSLSRSDSQVFEDSVELQSYFIKQRDELCKNGELLLSPAFNYTLPQLTADVESLRQTKLIRESFEDENETRSSDDSIIRDSNSGESLTLNQQTFKVGEFVYVDSKDKGVDPHILLIERLWTNNEGQKMLYGNYYLRPIETYHVTTRKFLEKEVFKSDTHVAVPLEEVRERCCIMNIKQYFSMKPELYDEKDVYVCESRYSTKTRSFKKMKVFPETPDILLVQREVPLEPKRVVSVFRERVEKHKDELAELQEQEKLIEKEKPNVVAFSSMEIDDGNIYYEQYNTICSGLVKTGDFVYVAADGGRQTIAQIDSIWETKDGKCFFRGPWFITPPEIPHSPTRMFYKQELFLSSLDDTNPIVSVVGKCCVLDYQDYISSRITEITESDVYICNSMYDEMNRQVRKLPSDGLKKYNHSNAVTEDEIYFFPKLINPLKVGSDVAQLQSDTIKPQSSTVVEVETLPVITKMTDMEVLIEDSLDGGPPSVGSGEIPTTVVTTTNNTLATPTTSKKKSNKNKVVTGYILYSREVRKNVVANNPESNFGEISRLVGNEWRSLPTNERQVYEEKAAKINEETKALLLNEECASPGPPVDQIYECLWDGCDFQFEEVSDLIEHCVKDKDGQGHVQSYFQANPDSEMNCMWRTCGRINKKNIQPFPNLSRLIRHVRDMHINKGNGRSVPPADRSKNFVGGRTMPVLQPCVSTTAEILAANSAPAVAVTQPQEPMFISIPPRPQRVLHSEAYIKYIEGLQTENKYISPWERTLNATRENTAPPDAEKLNLVSTWLGKTYEQQDDALNALWELRNQLLRDSLGIVKANSSVATTNTISSPWTPVTGPQADSNGAGPDTKNLDVGDVSEDEKDMTAADAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKLKVDHAAKEKALQTMSGMSSAQIVSATTMHSKSSSFGLNPTSYPGPQFWQPGLQPGTSQDVKPFQQTPYPGKPATAVSAGEVGPLQAPPPPPWEGRAIATHKLRLVEFSAFMEQHRDADNTYHKHLFVHIGGTATYADPLLEAVDVRQIYDKFPEKKGGLKELYDKGPQTAFFLVKFWADLNTNIQDEAGAFYGVTSQYESNENMTITCSTKVCSFGKQVVEKVETEYAHYESGRFIYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVSNRETQETLLCTAYVFEVSTSEHGAQHHIYRLVKD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00269761;
90% Identity: iTF_00269761;
80% Identity: iTF_00268247;