Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0036 14 7.0 0.1 11 45 106 141 100 150 0.80

2 6 0.022 87 4.5 0.0 11 45 134 169 129 178 0.81

3 6 0.0037 14 7.0 0.0 21 45 201 225 184 234 0.83

4 6 0.0042 17 6.8 0.0 11 44 218 252 213 257 0.85

5 6 5e-06 0.02 16.1 0.0 21 46 257 282 252 288 0.86

6 6 0.093 3.7e+02 2.4 0.0 22 44 286 308 281 312 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0036	14	7.0	0.1	11	45	106	141	100	150	0.80
2	6	0.022	87	4.5	0.0	11	45	134	169	129	178	0.81
3	6	0.0037	14	7.0	0.0	21	45	201	225	184	234	0.83
4	6	0.0042	17	6.8	0.0	11	44	218	252	213	257	0.85
5	6	5e-06	0.02	16.1	0.0	21	46	257	282	252	288	0.86
6	6	0.093	3.7e+02	2.4	0.0	22	44	286	308	281	312	0.88

Coding Sequence: ATGAACGAAATCAAGACTTTAgatgaattacaaattttagaaaatcctccttgcaatatttctaaaatttcgttTATTTCGGCTAGGGGGTTGCAAATTAAAACTGAAGAAGTCGAAGACATCGTTGACTACAAATTGGAAGATCTACATCATTCCATCGAAATTAAAGATGAAGATGGTTCGATCCTTGAAGCTGAGGTGAATAAAAAATACCAACGGCCTGCAATTGGGGTATTCGACAGCAAAAAATTCTTTTCGAAAAGTGATAGAAAACTGTTTACCTGTGAAGTTTGTGAGATGAAATTTGCACGTAAAGGAACTTTGAAAATTCATACacgaactcatactggcgaaaaaccttTTGGTTGTgaaatttgtcaacaaaaatttgttcagAGTGGAACTTTAAAAATTCATCGAAGAACCCACTCGGGTGATAAACCTTACGTGTGCCAAATTTGCAACAACAAATTTGCACAAATAGGAGGTTTGGAAGACCACTTAAGAACTCACAGGGGCGAAAAACTTTTCGCATGTGAAGTTTGCGAAGTGAAATTTGCGCGGAAGGGAAGTTTAAAAATTCATCTCCGCACTCACACAGGCGAAAAACCTTTTGTATGCGGAATTTGTCATCAAAAATTTGCGCAGAGTGGAACTTTAAAAATTCACTCAAGAACTCACACGGGCGATAAGCCATATGTATGtcaaatttgtaacaaaatgttTGCGCAAATCGGAGGTTTAGAAGATCACTtgagaactcataccggcgaaaaaccttTTACTTGTCAAATATGCGCGGCGAAATTTTCAAACagccaaaatttaaaagttcatttGAGAACTCACACGGGCGATAAACCTTACGAATGTCATATTTGTCGACAAAAATTTACCCAGGGAGGCAGTTTAAAATCTCATTTAGGAACTCATTCGGGTGAAAAACTTTTTCCTTGTGAAGTTTGTGAAgtgaaattttcaagtaaacaaGCTGCAAAAGTTCACTTGATAACTCATACAAACGATCGAACAGAACAATGA
Protein Sequence: MNEIKTLDELQILENPPCNISKISFISARGLQIKTEEVEDIVDYKLEDLHHSIEIKDEDGSILEAEVNKKYQRPAIGVFDSKKFFSKSDRKLFTCEVCEMKFARKGTLKIHTRTHTGEKPFGCEICQQKFVQSGTLKIHRRTHSGDKPYVCQICNNKFAQIGGLEDHLRTHRGEKLFACEVCEVKFARKGSLKIHLRTHTGEKPFVCGICHQKFAQSGTLKIHSRTHTGDKPYVCQICNKMFAQIGGLEDHLRTHTGEKPFTCQICAAKFSNSQNLKVHLRTHTGDKPYECHICRQKFTQGGSLKSHLGTHSGEKLFPCEVCEVKFSSKQAAKVHLITHTNDRTEQ

Sequence clustering based on sequence similarity using MMseqs2