Basic Information

Gene Symbol
-
Assembly
GCA_949152465.1
Location
OX424437.1:5032138-5034189[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 23 1.9e-05 0.0012 20.3 0.3 1 23 43 65 43 65 0.99
2 23 0.0042 0.27 12.9 2.6 1 23 71 93 71 93 0.99
3 23 0.0013 0.083 14.5 3.8 1 23 99 121 99 121 0.97
4 23 0.015 0.99 11.1 2.6 1 23 127 149 127 149 0.98
5 23 1.7e-05 0.0011 20.4 0.6 1 23 155 177 155 177 0.98
6 23 0.0001 0.0065 18.0 0.4 1 23 183 205 183 205 0.99
7 23 0.0029 0.18 13.4 3.5 1 23 211 233 211 233 0.96
8 23 0.00069 0.044 15.3 4.0 1 23 239 261 239 261 0.99
9 23 3.1e-05 0.002 19.6 1.0 1 23 267 289 267 289 0.98
10 23 0.00096 0.061 14.9 1.7 1 23 295 317 295 317 0.99
11 23 7.8e-05 0.005 18.3 0.9 1 23 323 345 323 345 0.97
12 23 0.00028 0.018 16.6 3.3 1 23 351 373 351 373 0.98
13 23 0.00021 0.014 16.9 3.5 1 23 379 401 379 401 0.98
14 23 0.0021 0.13 13.8 4.3 1 23 407 429 407 429 0.97
15 23 0.0019 0.12 14.0 6.4 1 23 435 457 435 457 0.99
16 23 0.0016 0.1 14.2 5.3 1 23 463 485 463 485 0.98
17 23 0.0027 0.17 13.5 1.5 1 23 491 514 491 514 0.95
18 23 0.00059 0.038 15.5 0.5 1 23 520 542 520 542 0.99
19 23 0.0002 0.013 17.1 1.4 1 23 548 570 548 570 0.98
20 23 0.00012 0.0077 17.7 2.2 1 23 576 598 576 598 0.98
21 23 0.028 1.8 10.3 1.9 1 23 604 626 604 626 0.95
22 23 1.5e-05 0.00094 20.6 1.5 1 23 632 654 632 654 0.99
23 23 4e-05 0.0026 19.2 0.9 1 23 660 682 660 682 0.99

Sequence Information

Coding Sequence
ATGAAGACGGAAGTAATAGAACCGAAGGTGGAACATCtgcatcattccatcgacattaaagaagacacttcaatttttgaatttcttccgAATAAAAAATGCGAAATCAAACCAAGCCTGAACCAGTATACCTGTGCAATCTGCGATTCCAAATTTGCCAGAAAAGATGGTTTGAGAATTCATTTAAGAAGTCACACCGGTGACAAACCGTATACGTGTGGATTTTGTGAGTATAGATGTGCTCGTAAGGATGTTCTAAAATTACACTTAAGATCCCATACCGGCGAGAGACCGTTTGCTTGTCATATTTGTGTGTGTAAATATGCCCGTAAGGAAAGTCTTACCATTCATCTGAGGAAGCATACGGGCGAGAGGCCGTTCACTTGTCGGAGTTGTGATTTTAGATGTGCTCGTAAAGAAGAGTTGATCATCCATTCACGAAGTCACACCGGCGAAGAACCATTTTCGTGTCAACTCTGTGATTATACAACTCCGCGTCTGGGCAATTTAAGAATTCATATGAAAactcacaccggggaaaaaccttATTCGTGTGAAATTTGCGACTATAAATCCGCGTTTATAGGCCAGCTCAAAAGACATATCAGAactcacaccggggaaaaacctttTATATGCTTTCATTGTGGGACCAAATTTGCAGCTAAGGATtgtttgaaaaaacatttagtAATTCACACTGGCGAGAAGCCGTTTAAATGCGAATTTTGCGACTTTAAATGTGTACGTAGGGATTATTTAGAAATCCATTTGAGAAAACATAcaggcgaaaaaccatttatgtgcgatatttgtgattataaaactACACAGAAGAAAAATCTGGTAAATCACCTGAAGgttcataccggggaaaaaccgtttaagTGTGAATTTTGTGACGTTAGATGCATGGACAAAGTTGGTTTAAAGAGGCACATAGAAACTCATGCCACAGAGAAACTTTTTAGTTGTGATATTTGTGATGGTAAGTTCACAACGAAAAGATATTTACTCAAACATGTAAGAGCTCATACGAGCGAGAAGAGGTTCAAATGttcaatttgcgattataaatgtgcgcAAAAGGTGAATTTGAGTACTCACTTCAGAATTCATACGGGCGAGAAGCCGTTTGAGTGTAAAATCTGCGGCTATAAATGTGCATATCAACATGGCTTGAAGAATCACTTGATAACTCATTCAGGGGAAAAACCGTTCttctgtaaaatttgtaattttcaatgCGCACGGAAGGTAAATCTGAGTAGTCACTTAAAAACTCATGCTGGAGTTAAATCATTTAAGTGTGAGTTTTGCGACTATAAGTGCACACATAAGCAGGGTTTAAAAAGTCATATCAAAGTTCATACTGGAGCCAAACcgtataattgtaaaatttgttccCATCAATTTGCGCATAAACAGAGTTTGGATAATCATTTGAGGACTCACACGGGAGAGAAGCCCTTTGCCTGCGAAagttgtgactataaatgtgcaCGTAAGGATGCTTTACGTAATCATGTAAAACTGACCCACATTGGGGGAAAACCCTATAAGTGTGAAGTTTGTGATTTTAGATCTTCAACAAAAGCATCTTTGGGTACTCACTTAAAAATCCACACCGGTGAGAAGCCGTACATTTGTAACGTTTGTGAGTATAAAACTGCGCATcagcaaagtttgaaaaatCACATAAGaattcataccggggaaaaaccgttttcaTGTACACTATGCTCCAACAATTTTTCAGATCAGAGTACTTTGAGGAAGCATCTGAAACTccacaccggggaaaaaccgtttttgTGTGAAAATTGCGATTTTAGAACTGCACATCGGGAATATCTAAAAATTCATTCGAgaattcatactggcgagaaaccatacaAATGTGTCATATGCGACTATCGGTGTGCGCGTAAGGGAGATCTAACAACTCATTTAAGAGTTCATACAGGCGACAAACCGTATAGGTGTGAAATCTGCGACTTCAGAACTGCTCAGAGTGGACATTTAAGTGCACACGTAAGAACTCATAAGTGA
Protein Sequence
MKTEVIEPKVEHLHHSIDIKEDTSIFEFLPNKKCEIKPSLNQYTCAICDSKFARKDGLRIHLRSHTGDKPYTCGFCEYRCARKDVLKLHLRSHTGERPFACHICVCKYARKESLTIHLRKHTGERPFTCRSCDFRCARKEELIIHSRSHTGEEPFSCQLCDYTTPRLGNLRIHMKTHTGEKPYSCEICDYKSAFIGQLKRHIRTHTGEKPFICFHCGTKFAAKDCLKKHLVIHTGEKPFKCEFCDFKCVRRDYLEIHLRKHTGEKPFMCDICDYKTTQKKNLVNHLKVHTGEKPFKCEFCDVRCMDKVGLKRHIETHATEKLFSCDICDGKFTTKRYLLKHVRAHTSEKRFKCSICDYKCAQKVNLSTHFRIHTGEKPFECKICGYKCAYQHGLKNHLITHSGEKPFFCKICNFQCARKVNLSSHLKTHAGVKSFKCEFCDYKCTHKQGLKSHIKVHTGAKPYNCKICSHQFAHKQSLDNHLRTHTGEKPFACESCDYKCARKDALRNHVKLTHIGGKPYKCEVCDFRSSTKASLGTHLKIHTGEKPYICNVCEYKTAHQQSLKNHIRIHTGEKPFSCTLCSNNFSDQSTLRKHLKLHTGEKPFLCENCDFRTAHREYLKIHSRIHTGEKPYKCVICDYRCARKGDLTTHLRVHTGDKPYRCEICDFRTAQSGHLSAHVRTHK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00271515;
90% Identity
iTF_00271515;
80% Identity
-