Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 6.2 2.3e+03 -0.6 0.0 72 101 135 164 120 173 0.71

2 3 2e-23 7.5e-21 75.0 0.1 10 108 194 292 186 294 0.93

3 3 0.29 1.1e+02 3.7 0.1 80 109 296 325 290 326 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	6.2	2.3e+03	-0.6	0.0	72	101	135	164	120	173	0.71
2	3	2e-23	7.5e-21	75.0	0.1	10	108	194	292	186	294	0.93
3	3	0.29	1.1e+02	3.7	0.1	80	109	296	325	290	326	0.88

Coding Sequence: ATGGAGTTAATGGACATAGAAAATACAGTATCCTCGTCTTCGAAGTCTCCCACTGGAGTTGAATCGGAGGCTAGCAGAGTTATAGAAGGACATCGCGCTTGCCAGACCCAGAAAGCGCAATGGTTGTGTATAAGCGATATTTACGAGAAACTACACCGACCGAACGTGTACGACATCGGCGGTACTTACATCGACAACGTGCCAGATTTCTGGTTCACCTGCAAGACTGAACGAAGCCATGACATTTGTCTTGTACACCTGTTCGCTGGAAACCGCACAGAAGGCACCCACTCTGTAGGAGTCAGCAGAGACTCCCTAGTGTACAATGATAAGGAAAAAATAGTCCGGATGACTGGAGAAATCGATTCATTCAAATTTCACTGTAAACTGCACAACCAAAGCTACATCACCACCATCACTATTGAACATTCAAGCGTAGAGAACATTCTAAAGGGCAAGAAACTTTATATTGCGGTCAAATTAGTACAAAAAGAGAAAAGtgaatttgttaaattccaggATGTCGTTGACTCTGTGAAGATGCATCATGACAATGCTGCGCTGATGACGGAGCCTGTCGGTACCGATTTCATCATAGAAAGTGAAGACGGAGAAAAGTTTCCGGTACACAGAAGTGTGCTGTCTCTCCACAGCGATGTCTTCAAGGCCATGCTTCACGAGGACATGGCGGAGAGCCGAACCGGCCGAGTCAAACTAATAGATGTCAACAGTGAAgacttaaaaataatgttagaaTACATCTACACTAGCACAATCAGTGTGATAGAGAATATAAATTTTCCCAATGTTATCATGTTGGCGGATAGGTACAATATTGTGGGGCTTCGGAAGCTGTGTGATCACATACTGATGGACCAGCTGGCTCCTGACACGGCCCTCCACGTCCTGGTGATGGCCGACCGGTTTGACTGCAGCAATGTGAAGAATGAGGCTCTCCAGTACATCAAAAAGAACAAAGAACTCTTCAAGGACCATAAGTTTGAGGAAATTGACAATATGGCCTTAATCAAAGAACTGTGttctattttattgttttag
Protein Sequence: MELMDIENTVSSSSKSPTGVESEASRVIEGHRACQTQKAQWLCISDIYEKLHRPNVYDIGGTYIDNVPDFWFTCKTERSHDICLVHLFAGNRTEGTHSVGVSRDSLVYNDKEKIVRMTGEIDSFKFHCKLHNQSYITTITIEHSSVENILKGKKLYIAVKLVQKEKSEFVKFQDVVDSVKMHHDNAALMTEPVGTDFIIESEDGEKFPVHRSVLSLHSDVFKAMLHEDMAESRTGRVKLIDVNSEDLKIMLEYIYTSTISVIENINFPNVIMLADRYNIVGLRKLCDHILMDQLAPDTALHVLVMADRFDCSNVKNEALQYIKKNKELFKDHKFEEIDNMALIKELCSILLF

Sequence clustering based on sequence similarity using MMseqs2