Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 6.4e-35 4.7e-32 109.4 0.2 2 85 105 186 104 189 0.94

2 2 5.8 4.3e+03 -2.7 0.1 12 37 198 223 196 241 0.57

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	6.4e-35	4.7e-32	109.4	0.2	2	85	105	186	104	189	0.94
2	2	5.8	4.3e+03	-2.7	0.1	12	37	198	223	196	241	0.57

Coding Sequence: ATGAGGATAGAACTGGCGGAAGTTGAAATATCGACGGAGGAGGAGTACTTGCCCGCTGCCGCCGCCGTCGCAGTGGACAACAGCAGTATGGACAGTAGCACGGACGATTACGACGGAGTCGAGGCCGAATTGACGAGCCTCTCCTGGCTGCAATCGTTGGACATCACCAGCGCATCCGGCTTGCCGACGCCGCCTTGTTCGCCATCGCCCCCGCCGGTCGTCCGTCAACCCCCGAAGAAACTGTCGCCTTTGGTCAAGGCCGAATTGGATCTCGCGGAAAATGCCGTCAAGTATCGAACGGATCCCGATGCGAAGCCACCGTTCTCTTACGCCACCATCATTTGTCTCGCGATGCGCGCCAACAATAATAAGGTCTCCCTTTCCAACATTTACGCATGGATTCGAGAGAATTTCCTGTTTTACAAATACGCCGATCCAGCCTGGCAGAATTCGATTCGGCACAATCTGTCGCTGAACAAATGCTTTGTCAAACTGCCGCGTTCTAAGGACGAGCCAGGCAAGGGCGGTTTCTGGAAGCTGGATCTCGAAAGAATGGAGGAAAGCAAACGATCAAGACGTCGCTCCGCGATCTCGCAGCGAATTCGCAACTCCAAGAAGCAATCCTCATCCGCGGCAAACACGACGACAACGATAGCGGCAACGGTaacggcgacgacgacaacgacgacggcAACGACGACGCTCAACGCTCTTCAGAACAGCTGCTCGCCACCCACCAGCTGTTTATCCAGCACTCTGTACGAGACCCCGCCTAGTAGCGTGTCACCCCCGATTCCGGACAGCCTGTCGGAAGTACCGGAATCGACGCAGGTGAGCTTGAGCGAGGACGATTTCACGAGCTTGTTGATCGCCGGCTGGGACGAAAATAATCAATTGGAGCTCCTCGATCTCTTGGACACCCTCTAA
Protein Sequence: MRIELAEVEISTEEEYLPAAAAVAVDNSSMDSSTDDYDGVEAELTSLSWLQSLDITSASGLPTPPCSPSPPPVVRQPPKKLSPLVKAELDLAENAVKYRTDPDAKPPFSYATIICLAMRANNNKVSLSNIYAWIRENFLFYKYADPAWQNSIRHNLSLNKCFVKLPRSKDEPGKGGFWKLDLERMEESKRSRRRSAISQRIRNSKKQSSSAANTTTTIAATVTATTTTTTATTTLNALQNSCSPPTSCLSSTLYETPPSSVSPPIPDSLSEVPESTQVSLSEDDFTSLLIAGWDENNQLELLDLLDTL

Sequence clustering based on sequence similarity using MMseqs2