Basic Information

Gene Symbol
MBD-R2_1
Assembly
GCA_001625245.1
Location
LUGF01026696.1:762773-778020[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2e-13 8.6e-10 39.2 0.0 5 64 539 596 535 618 0.88
2 2 2.6 1.1e+04 -2.9 0.0 36 45 733 764 721 766 0.57

Sequence Information

Coding Sequence
NNATCTGACGAATGGATCAGTGTGAGCAGCTCTAGGTTGAGGCCCATCGGCACTGCGAAAACAACTCCTCCCTTACAGACTCCCGTCTCACACGCCCCAGAGAGGAGTCATCAAGTCGTGAAGGAGGAAATGCCAGAGGAgaacaagagaccggcgtatgGTGTCGGTGAGCGGTGCCTGGCGCGGTGGAGGGACAATCGCCGCTTCGTCGCCACTGTGACTCAAGTTTTAAAAGATGgtaGCTACGAGATTATGTTTGACGATGGTTTTACATGGAAATGTACAAATTCCAGACTTTACAAACTGAAGGATTCCGGAAAAAATTCAGATAATCTCAGCATCGATACATCTGTCCATCCGTTGACATCAGCGCCCTCACCTGTCCAACCGGGCGTTGGTCCCAGTTCTGGAACTAATCAGACCTCGACCCACTCGCCGTTTCACACTCATTTGTTCGACCCCACACGCGATTACTTGGGTTCCAAAACGGAACGCCGTGAAATGAAAcgtaaattgaatattaaagagATATTTAATATCGgtcaaaagaagaaaaagatggCGACACCCCGGGAAAAGACTGTGCGGATTGtaaaagagaagaagaaaaagagagCCTATAGGCGGAAGGTCAAACAGGAACCAGAAGATGTGATCAAAAAGGAAATACCAGAAGCTGTAGCCTCTATAATCGGAACTGTTGGTCAAAATAATCCCATTGATAGCAAAAAAGGAACAGAAGCTAATATTTATGGTAGTGGAAAGGAAAATGACGAAAACAATGAATCTAAAACCGAAGCAGATGTTCCTGAACAGGACAGTTCAGATTTTTCTGACACACAAACTACCGAAAATAATGCATCAATAGAAACTGCTAGTGAGGAAGAAGTGAAACTTGTGAAATTCGATAAACCTGAAGGGAAGCATGAGCAAGTGattgataaaattaaagaagCAATTAACAAACTAGAGGGAGGAATAGAGGAAGTTAGTAAAATTACCCAAATTAAGGAAGAAATAAAGGATATTATGGAAGTTGATAAAATTGATTCACCTAAACCTGAAGTACAAGACGAAGTAGTTAAAGAAGAAAGAGAAAAGCTTGAAATTGCCAACGATGTACCTGTCAAAGAAGAAACCGTGCCAGAAGAAACACCAATACATACAGCCGAACCGTCAAAACAGCTATTCCTAAAGGAAGATGTAAAAGAAGAGATCGAGAAAGATAAAGTCGTCAAAGAAGAAACGACGAAAGAAGAATCCCAATGTGCCAAAGAAGTTAAAGAGGAAGAAGACGTGAAACCGAAGAAGAAGCTATCAAAAATAAAGAAGTGCAAAAAACTGAGGATGCTCCAAGAGAAGAAAGTGAAGAAACAGGTAGAGAAGGTTAAAAATGAATTGCAAGATATGAAGAGACAGATTGAAGAAATGAAACTGCAAATGTTGCAGAAGACGGAAGAGCTGGCGGCCAAGAATCTGGAGATGCCGGAGAGTTTCTTGCTGCCGGGCGAGTGGTGCTGCAAGTGGGTCAACGGCCAGCCGGTGGGCACAGTCAGCGAGCTGGAGAGCGAGCCGCAGGCCAGCAACAGACTGGGGCTGCCGCGGCGGAGCGTTCAGgtcgaGGATAAAAGACTACCCGAGGGATGGACTAAACACATGGTGAGAAGGAGCCTGGGCCAGTCCGCTGGAAAATGGGATGTGGTATTAGTGGGTCCCGACAACAGACGTTTTCATACGAAGACCGACATGCGCAACTTCATGGAGACCCACGGAGAGTCGCTCAAGCATTATGAGCATGCGTTATTTGACTTTGGGGTTCACCTGAAACTGGCCAGGCGTATGGGCTGGTACAAGCGGACCAGCGAAGACGCGCCCCCGCCTACTGGCGTCATCAACAGTCTCTCGCCGCTGGTCAAGAGGAAGAGTTTCATGAAGAAGAGAGAACATAAAGAGAAGAAGAGAAGGATGAAAGCCTCGTCTAAGTCTTTGTCACTGCCGCCCGCCGAAGCGAGCGAGCAGACGCCAGCTGTTGCGGAGGCGCCAGAAATGATTATCGACAGGACGCCCGTGGAGGACGGATACGTGTTCGTGGGCTCGTTGAAAGTCCAAGTGATCGACAATCTGCTCCGGTGTCCGGCCGAGGGCTGCTACAAGTCGTTCAGAAACAACACCCTCATCAAAATGCACATTAAATATTACCACCGAGACCTGAGGAAAATGCTCGGGGCCACGCCGAAGGTTCTAGATCTAGCCTACGCTCGGACAAAACCCACGGGCAAAGAGGTGAAGAAGAGACGACCAGCGAACATGACTAAGGTCATCAAAGTGAAACTACCGAAACTCGAAGACGTGAAACCGCAGCCAGAACCTTCCGAGGTGACCGTGGAACCTACCATCCAACCGAGACCGCCCAGATTAATACCCAGGTCTCTGGACTCGCCCAAACTCCGCCAGGTGCTAGCTAACAAGCCGGTCAAGCGGCCGAAGGTCCTTCTTCCTGTCAGAAGGCCCGATCCCGAACCAGAGGAGACCATAGTCGAGTTAGATGACGTAAAAATCTCGATCCCGGACATACCGCTGGCCCTGGACTTCGAGACGGCCATCGCGACGCACACGGTGACGAAGCCGGATGACTGCAAGGCCGTAAAGGACGAGGACGATTGGTACGGCCACTCGGACTTCGACACGGCCAGCTGCCCCGGCTCGGGCAGTCCGGACTCGAAGGCCGCGGAGAAACAAAATGAGGAAGTACAGGAGCAGACCGGCTACGAACAGCCAGATGTGAAGGAGAACATGTATATGTATACAGAAAGCGGCGAGAGGATAAAGATCGAGCACATGAAGCGCGAGGAGATCATCAACTGTCACTGCGGGTACCGCGAGGAGGACGGACTTATGGTGCAGTGCGAGCTGTGTCTGTGCTGGCAGCATGCGCTGTGTCACAACATACAGAGGGAGGCAGAGGTGCCTGAGAAGTACACATGCAGCATATGCCTGAACCCGAAGCGGGGGCGGCGCTCCAGGCGGTTCCTGCACGACCAGGACCGGCTGTACGAGGGGCTGCTGCCGGGGGCGAAGCCCTGcgagtcgctgcggcgctcgcaCGAGCTGTCCGGCAACTTGCTAAGGATACAGGACGCGCTGCACGCGTTACGTGTCAAGTATCACGTCGCCACAACAAAGAACCATCCCAAACTGTATCTATGGGCGAAGGACTGGGAGAACGCCGAGATAACGATGACCCAAGAGAAACTCAATTCAGACTACTCGGATCTGAACATTATCATCAACAACATCGGCAAAGAGAATCTGCCGGTCAAGTCGGACGATATGAAGGACTTGTTGGAGGACGAGCAGAGGGACTTGAGTATGAACTCCCTGGCCAGCCCCGGAGGTACTTCCCTGGACCTGCCCATCAGCACTGCAGACCTGGAGCGGCTGGCGAAGACCGTTCAAGAACAAGATGGCGGTCGTGTGGGCGTGACGGGCCCGCAGCCCGAGGCGGCCATCGACAACGGCGTGTGTCGCGAGCGCCTGCTGCGCCATCTGCAGCGCTGCCAGGCGCTCATGGACGCGCGGCTCGACTCTATCGAGGCGCAGGTCGCAGAACTTGAGTCACAAGATCCATCCTTTGAAGACGATGAAACAGCAGACTATTTCCCAAGGACAAAACAGACAATACAGATGCTAATGCGCGATCTCGATACCATGGAAGAGTTGGGGATTATCACATAG
Protein Sequence
XSDEWISVSSSRLRPIGTAKTTPPLQTPVSHAPERSHQVVKEEMPEENKRPAYGVGERCLARWRDNRRFVATVTQVLKDGSYEIMFDDGFTWKCTNSRLYKLKDSGKNSDNLSIDTSVHPLTSAPSPVQPGVGPSSGTNQTSTHSPFHTHLFDPTRDYLGSKTERREMKRKLNIKEIFNIGQKKKKMATPREKTVRIVKEKKKKRAYRRKVKQEPEDVIKKEIPEAVASIIGTVGQNNPIDSKKGTEANIYGSGKENDENNESKTEADVPEQDSSDFSDTQTTENNASIETASEEEVKLVKFDKPEGKHEQVIDKIKEAINKLEGGIEEVSKITQIKEEIKDIMEVDKIDSPKPEVQDEVVKEEREKLEIANDVPVKEETVPEETPIHTAEPSKQLFLKEDVKEEIEKDKVVKEETTKEESQCAKEVKEEEDVKPKKKLSKIKKCKKLRMLQEKKVKKQVEKVKNELQDMKRQIEEMKLQMLQKTEELAAKNLEMPESFLLPGEWCCKWVNGQPVGTVSELESEPQASNRLGLPRRSVQVEDKRLPEGWTKHMVRRSLGQSAGKWDVVLVGPDNRRFHTKTDMRNFMETHGESLKHYEHALFDFGVHLKLARRMGWYKRTSEDAPPPTGVINSLSPLVKRKSFMKKREHKEKKRRMKASSKSLSLPPAEASEQTPAVAEAPEMIIDRTPVEDGYVFVGSLKVQVIDNLLRCPAEGCYKSFRNNTLIKMHIKYYHRDLRKMLGATPKVLDLAYARTKPTGKEVKKRRPANMTKVIKVKLPKLEDVKPQPEPSEVTVEPTIQPRPPRLIPRSLDSPKLRQVLANKPVKRPKVLLPVRRPDPEPEETIVELDDVKISIPDIPLALDFETAIATHTVTKPDDCKAVKDEDDWYGHSDFDTASCPGSGSPDSKAAEKQNEEVQEQTGYEQPDVKENMYMYTESGERIKIEHMKREEIINCHCGYREEDGLMVQCELCLCWQHALCHNIQREAEVPEKYTCSICLNPKRGRRSRRFLHDQDRLYEGLLPGAKPCESLRRSHELSGNLLRIQDALHALRVKYHVATTKNHPKLYLWAKDWENAEITMTQEKLNSDYSDLNIIINNIGKENLPVKSDDMKDLLEDEQRDLSMNSLASPGGTSLDLPISTADLERLAKTVQEQDGGRVGVTGPQPEAAIDNGVCRERLLRHLQRCQALMDARLDSIEAQVAELESQDPSFEDDETADYFPRTKQTIQMLMRDLDTMEELGIIT*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-