Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.017 5.1e+02 3.5 0.0 21 45 6 30 3 34 0.90

2 9 0.0074 2.2e+02 4.7 0.1 22 45 35 58 30 65 0.88

3 9 0.0017 51 6.7 0.1 22 46 63 87 60 93 0.86

4 9 0.00033 9.8 9.0 0.0 22 45 91 114 86 122 0.88

5 9 0.88 2.6e+04 -1.9 0.0 22 43 119 140 116 144 0.77

6 9 0.0011 33 7.3 0.1 21 45 146 170 142 179 0.85

7 9 0.057 1.7e+03 1.9 0.0 21 44 202 225 199 234 0.84

8 9 0.0029 86 6.0 0.0 21 48 258 285 255 291 0.85

9 9 0.086 2.6e+03 1.3 0.0 22 44 287 309 282 313 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.017	5.1e+02	3.5	0.0	21	45	6	30	3	34	0.90
2	9	0.0074	2.2e+02	4.7	0.1	22	45	35	58	30	65	0.88
3	9	0.0017	51	6.7	0.1	22	46	63	87	60	93	0.86
4	9	0.00033	9.8	9.0	0.0	22	45	91	114	86	122	0.88
5	9	0.88	2.6e+04	-1.9	0.0	22	43	119	140	116	144	0.77
6	9	0.0011	33	7.3	0.1	21	45	146	170	142	179	0.85
7	9	0.057	1.7e+03	1.9	0.0	21	44	202	225	199	234	0.84
8	9	0.0029	86	6.0	0.0	21	48	258	285	255	291	0.85
9	9	0.086	2.6e+03	1.3	0.0	22	44	287	309	282	313	0.87

Coding Sequence: ATGGCGCTGCACTCTGGAGAGAAGCCCCATTTCTGCGGGTTGTGCTCCAAAGCGTATGCCACGAGCAAATCCCTCAAGAAACACTTCAAGACGCACACCGGAGACAGGCCTCACAAGTGCGCTGTGTGCTCCAAGTGCTTCAGCACGAGCAGTaacctcaaggatcacttcaagACGCACACCGGAGACAGGCCTCACAAGTGCGCGATGTGCTCCAAAAGCTTCAGGACGAGCAGTAACCTCTCGCATCACTTCAAGACGCACACCGGAGACAAGCCCCACATCTGCGGTGTGTGCTCCAAGGCGTTCGGGAATAGCCGTTCGCTAAAGAGACACATGGTCGTACACACCGGAGACAGACCGTACAAGTGCGCCGTGTGCTCAAAAGGCTTCAGCAACAAAATGAACCTAAGTGGTCACGTATGGAAACACACCGGAGAAAATCCGCACAAGTGCGGGGTGTGCTCCAAGGGATTCAGCTCGATCAGCAATCTCAGGAGACACATCATTACGCACACCAAACACAAGCCTTATAAATGTGCCGTGTGCTCAAAGGGCTTCAGCACTAAAACGACTCTGAAGGGTCACTTATGGATACATACCGGAGAAAATCCGAACAAGTGCGGGGTGTGCTCCAAGGGCTTCAGCTCGAACAGCAACCTCAAGATACACATCATTACGCACACCAAACACAAGCCTTACAAGTGTGCCGTGTGCTCAAAGGGCTTCAGCACTAAAACGACCCTGAATGGTCACTTATGGACACACACCGAAGAAAATCCGAACAAGTGCGGGGTGTGCTCCAAGGGCTTCAGCTCGATCAGCAACCTCAGGAAACACATCAGAACGCACACCAAAGACAAGCCTCACAAGTGTGCCATGTGCTCCAAGACGTTCGGGCCAAGCGGAACGCTCGAGAGACACATGGTTGTGCACACCAATGAATGTCGCAGCAATGCGCCGTGTACGACAAGGCACCAAACAATCACTGACCCTTATCTGTTTTCATTGTCAGAGTATTGA
Protein Sequence: MALHSGEKPHFCGLCSKAYATSKSLKKHFKTHTGDRPHKCAVCSKCFSTSSNLKDHFKTHTGDRPHKCAMCSKSFRTSSNLSHHFKTHTGDKPHICGVCSKAFGNSRSLKRHMVVHTGDRPYKCAVCSKGFSNKMNLSGHVWKHTGENPHKCGVCSKGFSSISNLRRHIITHTKHKPYKCAVCSKGFSTKTTLKGHLWIHTGENPNKCGVCSKGFSSNSNLKIHIITHTKHKPYKCAVCSKGFSTKTTLNGHLWTHTEENPNKCGVCSKGFSSISNLRKHIRTHTKDKPHKCAMCSKTFGPSGTLERHMVVHTNECRSNAPCTTRHQTITDPYLFSLSEY*

Sequence clustering based on sequence similarity using MMseqs2