Cmac001083.1
Basic Information
- Insect
- Callosobruchus maculatus
- Gene Symbol
- Mbd2
- Assembly
- GCA_900659725.1
- Location
- CAACVG010001216.1:627358-630955[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 3.4e-09 1.3e-05 24.8 0.2 8 73 15 97 8 101 0.87
Sequence Information
- Coding Sequence
- ATGGCGAGCATAACAATCGAGAAAACAAAATACGAGTGTGCCCAGCCCCAGCTATCCAAGAAATGGCAAAGGGAAGATGTGCTAAGGAAAACGGGGCTTTGTGTGGGTAAAGTGGACGTGTACTACAGAAACGCCCGAAGTGATGGTTGTTTGGTGCCCCCAATTCGACAGACAGCCAGCATCTTCAAGCAACCGGTCACTGTTTATAAAACACAAGAAGGTAAAGTAAAATCAGATCACAAAAACGGCAATCAAGAAAAACCGAAACAACTTATGTGGGAAAAACGTTTAGAAGGTCTGAGGGCTTGTGATATAGATGGTCATGAGTTTGAAGCGATGGAACTACCAAAAGGTTTAAAGCCTGTGGGACCAAATGTCAACGAAGAGACAATCATACAAAGTGTGGCGACTGCACTACACGTTTCTTCTCAGCCCGTTACAGGACAGACTAACACAAAGACCCTGTTAGAAAAAAACCCTGGCGTTTTCTTAGACCCCAAACAGCCATTGGTTCATGCTGTTAACATTTCAGATGAAGATATCAAAAAGCAAGAAGAAAGAGTAGCATTAGCAAGGAAAAAATTACAGGATGCTCTAAGGATGTGA
- Protein Sequence
- MASITIEKTKYECAQPQLSKKWQREDVLRKTGLCVGKVDVYYRNARSDGCLVPPIRQTASIFKQPVTVYKTQEGKVKSDHKNGNQEKPKQLMWEKRLEGLRACDIDGHEFEAMELPKGLKPVGPNVNEETIIQSVATALHVSSQPVTGQTNTKTLLEKNPGVFLDPKQPLVHAVNISDEDIKKQEERVALARKKLQDALRM
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01351724;
- 90% Identity
- iTF_00248963;
- 80% Identity
- -