Basic Information

Insect: Callosobruchus maculatus
Gene Symbol: ZFHX3
Assembly: GCA_900659725.1
Location: CAACVG010008620.1:191507-348673[-]

Transcription Factor Domain

TF Family: Homeobox
Domain: Homeobox
PFAM: PF00046
TF Group: Helix-turn-helix
Description: This entry represents the homeodomain (HD), a protein domain of approximately 60 residues that usually binds DNA. It is encoded by the homeobox sequence [7, 6, 8], which was first identified in a number of Drosophila homeotic and segmentation proteins, but is now known to be well-conserved in many other animals, including vertebrates [1, 2], as well as plants [4], fungi [5] and some species of lower eukaryotes. Many members of this group are transcriptional regulators, some of which operate differential genetic programs along the anterior-posterior axis of animal bodies [3]. This domain folds into a globular structure with three α-helices connected by two short loops that harbour a hydrophobic core. The second and third form a helix-turn-helix (HTH) motif, which make intimate contacts with the DNA: while the first helix of this motif helps to stabilise the structure, the second helix binds to DNA via a number of hydrogen bonds and hydrophobic interactions, which occur between specific side chains and the exposed bases and thymine methyl groups within the major groove of the DNA. One particularity of the HTH motif in some of these proteins arises from the stereo-chemical requirement for glycine in the turn which is needed to avoid steric interference of the β-carbon with the main chain: for cro and repressor proteins the glycine appears to be mandatory, while for many of the homeotic and other DNA-binding proteins the requirement is relaxed.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 3.8e-15 8.9e-13 47.9 0.2 1 57 1837 1893 1837 1893 0.97

2 3 3.8e-20 9e-18 64.0 0.5 1 57 2099 2155 2099 2155 0.98

3 3 7.8e-08 1.8e-05 24.5 0.1 1 42 2416 2457 2416 2461 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	3.8e-15	8.9e-13	47.9	0.2	1	57	1837	1893	1837	1893	0.97
2	3	3.8e-20	9e-18	64.0	0.5	1	57	2099	2155	2099	2155	0.98
3	3	7.8e-08	1.8e-05	24.5	0.1	1	42	2416	2457	2416	2461	0.96

Sequence Information

Coding Sequence: ATGCCCACTGTGTCCGCGGCGCGTGAGCATCCGAGTCCCGGCGGCAACCGCACCGACACCCCCGCTGACCCCCCCGGCCGCTCCGACGCTGACGCCAACGCCGCAGAGATGAGTCCAGAACAGGAGGCCAGTCCGCCGCCGGCCGCACCAGGTGCGTCACCGCCTCCGCCACCGCCTCCTCCCCCCGCGTCCGCGACGCGGTTGCCTTCTACGTCTCCGCACCAAGAGGGCGCCACCTCGGACGTGGAACAGTTCTCGGGAAAGATCGTTTACAACCCGGACGGTTCCGCCTACATCATCGAGGATTCGGAGAGCGAGGGGGAGGCGCAAACGGGATCGGGGGGCGGGCAGATGCCGGCAGCGGCAGCAGACGTGCCCGTAGTGCCCGCCCCCCTACAGGCGGTCTACGTGTCCAGGCTCATGCATGCCAAAGCCGGcgtGCGTCAACCAGCGCATCCGACGGAACTGCCTGCGGTGCACAGCTACCGCGTGGTGGCGCTGCGGGACGCGCGACCGCCGCGGCCAGCGTCTGTGCCCGTGAAGCCCATCCTGATGTGCTTCGTGTGCAAGCTAAGCTTCGGCTTCGCCAGATCGTTCGCCAACCACGCGCAGGCCGAACACGGCGTCACGCTGAAGGAGAACGAGCGTGAAGTGCTAGCCGCAGACTGCTCCGCCATCTTGCAGTGCGTGGGGGTGGACAAGAGGCCCATGGTGTCGCTGCTCGAACCGCTCGTGCACGACCCCCAACACCACCACTCCAATCAAATAGTTCCTGTTCATACTGTACAAAATCGAAACGAAGGTCCTTCGCCCGTCAGCGAGACCCCGCCATGTTCCTCGACCCGGACGACTCCGGGCAAATCTCCGTCACCACCTTTCGCCACACCACCTGCCTTCATGACCGGCACAACGATAGGAGTCTGTCCGGAGCATCTTCAAGGCAGGCCCTCCGGAGTCGAGTGTGCCCGCTGCGAGATGATCCTCGCCTCCGGGAGGTTAGGCCCCGCCGGCTTGGCGAACGTGCATAGCAGAAACTCGTGTAAAACGCTTAAATGTCCCAAATGTAATTGGCATTACAAGTACCAAGAAACCCTCGAGATCCACATGAAAGAAAAACACCCGGAAGCTGAAACTAGTTGCATTTACTGCATAGCGGGACAGCCTCACCCGCGGTTAGCACGAGGCGAAACCTACACCTGTGGCTACAAGCCGTACCGATGCGAGGTCTGCAACTACTCAACCACAACCAAAGGCAATCTCAGCATACACATGCAATCGGACAAACACTTGAACAACATGCAGGAATTGCAGAACGGTGGAGCACCCAATCAAGAAGCCCGACAGGCCTCGCCCAAAGCTCCGCCGCTACACCACTCACCCGTCAGCAGCGGCCACAAACCTAAACCTAGCTTCAGGTGTGACGTGTGCAACTACGAGACGAACGTCGCAAGAAACCTGAGGATACACATGACCTCCGAGAAGCATACGCATAACATGCTGGTGCTACAACAGAACGTAAAACATATGCAAACGTTGTCAGCGTTGCACCATCAACAACACCCCCAGCAGCACATGGAGAGTTTGTATGGAATGTACCCTGGATTGGGTGACAAGCCTGAAGCTGCTCTTGCTGACATGGCGTACAACCAAGCGCTGCTAATACAGATGATGACTGGTGGGCAGATACCTGGACATGGAGGTCCCGCGGATATGTCTGCACACTCCGACCTCGGATTGAATCCCGAAACGATGGAACCACCTCCGGAACCGGCAGATCCTGATCCTGATAAGATATTTCAATGTTGTGTATGTAACGTGTTCCAAACGGATAGCCTGGAGGAGCTGGGTAGGCACCTGGCGCTGGATCGAACGAGACTGCGGGAGCAAGAGATCCTCGCTGTGGTGGCAGGCCACTATGTCTGTAAGCTatgtacatacaaaacaaaCCTGAAAGCCAACTTCCAATTGCACTGTAAGACTGACAAACATCTCCAGAGACTCCAGCACGTAAACCACGTGAAAGAGGGCGGCCCTAGGAACGAATGGAAGCTGAAGTACGCTTCAGCACCTGGAGGCGTGCAAATCCGTTGCAACGCCTGCGACTACTACACGAACTCCGCGCACAAGCTTCAGCTGCACGCCGCTGCTGGAAGGCACGACGCTGGAGTGGCTCTGTTGAAGCACCTGCTGGAGAGGTGTTCGACATTGAGTCCGAACCAAGCGCGCGTGTTCCATTGCTCGCTGTGCGGATTCTCCTCGACGAACCGACTGCCTCTCCTGCAGCACGTCCGATCTCTGAAGCACCTGCATATGGAGCAGCTACATCAACTGCAAAGGCGAGCTGAAGGAAAGGACAATTCGCCGGAGATCGGGGAAGTTTTTCACGTCGTACCTGCACCTATCGAACACCAACAACAGCATCAACCTCATCAAATGACGCAAGAACGTCGAGATAGCGTAAACTCGGAGCAAAGCCAACATGACTCTACACGAGACCAGGTCAAATCAGAACCTCGTGAAGAACTGGAAGAGCAGCCAAGCTCTGAAGGAGGATCTCAACAACATATGTGTCCCTTTTGTGAGTATTCAAGCGATTCTGAGATGCGTATTCAAGCGCATATTTTGGCTCAACACGGAACTAACAACGCACCGCCATCTCAAGAACAACCTCTGCTCCATTGTCCGCTGTGTCAGGATGCGTTCAAAGATAGGACAAGCTTAGAGCGCCACGTTATGCAGATCCATTCCGTTAACAGCGAGGGTCTGCAACGATTATTGATGCTCGTGGACCAGAGTCATTGGTTGAACCAGTCGTCGAGAACCCCTACACCTAACAATTCAATGCAAGTGCAGCAAACTGTATCGCCTACATCCGTGTCTTCCAAAGAGTCTAATAGGTTCGAGAAGAGCGATCCTAGTCACCAGGACACTGAACCTGACCTTCTCTCACCCACCAGCGATGACAATCCTGAAGAATCGGAACGTTGTGGAACTTGTTATAAGACATTTCGCAATATCGATGAACTCTGCTACCACCAGAATGAAACTGGACACCTGGAGATCAAGCAAACACCAAGCGGTCCCGGGTACGTCTGCTGGAAGAAAGGCTGCAACCAGTTTTTTCCAACAGCGCATACTCTCCAGATGCATTTCAAGGAAGTACACGCCAAAAATTCGATCGCGAATATGTCGGTGTCGGAAAAACACGTCTACAAGTACAGATGTAACCAGTGCTCTCTAGCTTTCAAGACCTTGGAGAAACTGCAGCTACACTCGCAGTACCATATGATCCGGGATGCCACGAAGTGTGTTTTGTGCGGTCGCAGCTTTAGATCACTGGTGGCCTTGCATAAACACGTTGAAAGTGTTCACTCTGAGCTGACCGATGAGGAGCTGAACGCCTACAAGACAAGTCTGATGAATAACCCGCTGCTGTTGGCTGGCCTGCAAGGACAAGTATTGGATAGCTCCACCAACGAAATACTGAAAAAGGAGTCTTTACGCAGCGAAGAGGAATCCGGAGAATGCGACGACAGCAAAGAACTGAGCACTAGTCAGTCATTAGATGATAGCAATCAAAACGACGGCGATAATTCTGATGACAGCATCATCTACAAAGATCAGCAATTCTTAGAAGACTACCTGAACTCCCAGGCAATCGCCGAAGACAGTTACAATGACCCAAATAGAAAATACAAATGCCATCGGTGCAAAGTAGCCTTCACAAGACAAAGCTATTTAACCGCCCACAATAAAACCCTTTTGCACCGAAAAGGTGAGAAATTAAGCTACCCTATGGAGAAATACCTGGACCCGAACCGGCCTTACAAGTGCGACGTGTGCAAGGAGAGCTTTACACAGAAAAATATCCTCCTGGTGCATTACAATTCGGTGAGTCATTTGCATAAATTGAAGCGCGCCATGCAAGAACAgcaaaataataacaacaatCCGCCTATATCGCCGATAACCGGCGGGACGCAACCACAGAATTTGACGTTAACCCCAAAAAGCACGTCATCCGAAGAGGACGACAAGAAGAAATATCGGTGCAATATATGTAAAGTGGCCTATACGCAAGGTAGCACGTTGGATATCCATATGCGTAGCGTGCTCCATCAAACTCGGGCAAGCAAGTTACAAGATTTAGCGATGGCCGGACAGATAGACCTGACAAAACCATTAATTGAACAACCCGATGCCATGCAGTCTCCGAAACAGCCAAGCCCGACGCCAGGTAGTGGGGACAAACAACCCTCTCCTACCACCCCACCATCACCTGGCCTCTCAGGTAGCCAGCAGCAGCCGCAGGGGATGATGAGCCTGAGTTGTCCGAAGTGCGGCGCGCAGTTCACCTCGCAAGACCAGTTGAACGCTCACCAGCAGTTGTACTGCATGTTCGCCTCGCCTATGGCGATCTTCCAAGGGGTGCCGGAACCGGGTCAGGCGAAATCTCCACCACCTGGTGGCACGGAACAGGACGCCGCCGCGGCGATCCGATTGAACTTGCCCAAGAAAACGGGTTCGCACATGTACAAACACCTACTGGAAAGCTTCGGGTTCGATTTAGTGATGCAATACAATGAGACGCACCAGCGAAGACAACGGCAGCAGCGAGAAGCGGAAGAAAAAGCTGCTAGCGAAGCGAATACACCACCGCCTCCGAAGGAAGAGGAGCCGGCCGCTATTGTGGAAGCAGCGCCTGCTGCGACTGAGTGCGAACTGACTGACAACAAGCAGACCACCGAAGAAGATGTCACGGATAGCGACCTACCCGAAGTAAGTAAATCTACGTGCCAACATTGCAATAAAGAGTTCTCTAGTGTGTGGGTGTTAAAATCTCACTGTGAAGAAGTTCATAAAGATTTAGTGCCACTTGAATTCTTAGAAAAGTATGCTCAACAGTTCAAAAACGAGTACGAAAAGAAAACCGTGGTGGTGACAGCGGCGACGTCGTCGACAGTGAACACTACCCCGAGGTCCACGACGCCCGGTGGATCGACGCCTACGACAACGGCCGTACCGACATCCACGAGCCCAGTGGAGAACACCCCCACACCAGAAAAGGAGGACGAGTCCAAAGAGCAACTGCACCAGAAGCTCAACATTCCCCCGGAAGCCCCATCTACGCCGACGTCTTCTACCACACCGGCAAGCAGTACGGACTCCTTGCCGGCCAACATCCAGGCCATGATTGCGCAAAGCATGGCCCAGAACCCGATGGCCTTGGCCCAGCAGATGTCCGAGATGCAGGCCGCGCTCAACGTGATGCAACTACAACAGTTGAACTTCAGTCCCATGATGCAGATGATGGGCATGGGGCTTCCACTGGGTCTGAATGCTCTGGCTGCGATGAACCTTCAGCCCCCGTTGGTACCGCTCATGATGCCACCGCCACCTTATGATCCCATGTCTCAGTTCGGACCTCAGGACCAGCAGGCATTGTTGGCCAAGCAGCAACAGGCGATGATGCAGCAACAAGCGGCCGTCAACGCTGCAGCTAATCAGAAACGAGCCCGCACCCGCATTACTGACGACCAACTGAAGATCCTGCGAGCTCATTTTGACATCAACAATTCTCCATCCGAAGAACAAATCCACGAAATGGCATCCCAGAGTGGTCTTCCGCCCAAGGTCATCAAGCATTGGTTCCGCAATACGCTTTTCAAAGAGCGGCAAAGAAACAAGGACAGCCCGTACAACTTCAACAACCCACCTTCTACCACATTAAATCTGGAGGAGTACGAGAAGACAGGCGAGGCGAAGGTCATGCCTTTAAACAGTTctggtagtagtagtgatgaacACAAGCCCACCAAGGACTCTCCACACCAATCTCACAACGAAATAAAAACTGAGATGAAAGAAGAGCCCGTTGAGGAGCAACCTCCGCCAAAATATGAAGAGAAGCAACAAGAATGTAATGAAGAAAAGCCTAACATATTTAACTTGCCTCTAAATCTGCAGCCACCGCAGAGCCCTGTAACCTCAATCGCCAGTTCTGACAACCAAAGCGTATCGCAACCAAGCACACCCAATAATCTTACTCTAACATCGATTATAGCTTCTCAGCTTGGTGACACTATCACAACTAGCACTCCGACGATGAATATGACCAACATGAGCACTCATCATGGGCTAACTAGCCCAATGCTACCACCACCAAAGCTGAATCAACAGAATTTTCCCAACCCAAACAATATGCAAGGTATGTTGCCTCTTACACCAAATAGGTGTTTGAGCCCAAGCAGAGAATACAGCAATCCTGGAAGTAACTCCGGATCTACTGGTAAGAGAGCTAATAGGACAAGATTCACTGACTACCAAATCAAAGTCCTCCAagagtttttcgaaaataatgCATACCCCAAAGACGATGATCTCGAATACCTATCCAAGCTCCTAAGTCTCAGCCCTAGGGTAATAGTTGTCTGGTTCCAAAATGCTAGACAGAAAGCTCGGAAGGTCTACGAAAACCAACCTGCAGCCGATCCAGTACCTGGTATCCCTGACGAAAGCGGAGCTAATCGATTCCAACGCACTCCAGGCTTAAATTACCAATGTAAAAAATGCCTATTGGTATTCCAAAGGTACTATGAACTTATTAGGCATCAGAAGACGCATTGCTTCAAAGAAGAAGACGCTAAGCGATCAGCTCAAGCTCAGGCAGCAGCTGCTCAAATAGCTGCTGTTCTCAGCTCCGAAGACTCGAATTCAAGCACTACCGTAGAGCAACAGCAACACCAAGCTCCTCCTCAGCCGCTACAATTGCCGCCCCAAGCAGGTGTGCAACAACAGCAGCAACAACCTGTTCAGCAAAATCCAGCACACAGTCCTTCCTCTCAGCCAAATCCTTCCACTACTCCCACTCCAAGTCAAAGCCAAAGCAGTTTTGCTCCCACGTCTCCCTCACCCTCAGAAACAAAAGAGGGTACCTTCCAGTGTGACAAATGTAACCTAGTTTTTCCACGTTTCGAACTCTGGCGAGAGCATCAGCTGGTCCATCTGATGAATCCCAATCTCTTTCCGCCTTCATATCCGCCAGATTCTCCGTTTGGGATTCTGCAGCAGCATGCTCAGCTGCAGCAACTAAACTCGAATTTAGATCTAAGTAAGCCGCAGAATAATGCTCCTCAGCAGAATATTCCGCATCCTCTAATAAACATGTTAAACAATGTTACTGGACAGAAAAGGAAGGTCGAAGAATTTGAAGGTGAAAGCGATACGTCTGATCAACCGAAGGACAAAAGGTTACGGACGACTATTCTGCCAGAACAGCTTGACTATTTATATCAAAAGTATCAAATCGAAAGCAATCCTTCGAGGAAAATGCTAGAAAACATTGCTAGAGAAGTCGGACTAAAGAAGCGGTGGTGCAGGTATGGTTCCAAAACACTAGAGCCAGAGAGAGAAAAGGGCAATTCAGAGCTCATGCTCAAGTGA
Protein Sequence: MPTVSAAREHPSPGGNRTDTPADPPGRSDADANAAEMSPEQEASPPPAAPGASPPPPPPPPPASATRLPSTSPHQEGATSDVEQFSGKIVYNPDGSAYIIEDSESEGEAQTGSGGGQMPAAAADVPVVPAPLQAVYVSRLMHAKAGVRQPAHPTELPAVHSYRVVALRDARPPRPASVPVKPILMCFVCKLSFGFARSFANHAQAEHGVTLKENEREVLAADCSAILQCVGVDKRPMVSLLEPLVHDPQHHHSNQIVPVHTVQNRNEGPSPVSETPPCSSTRTTPGKSPSPPFATPPAFMTGTTIGVCPEHLQGRPSGVECARCEMILASGRLGPAGLANVHSRNSCKTLKCPKCNWHYKYQETLEIHMKEKHPEAETSCIYCIAGQPHPRLARGETYTCGYKPYRCEVCNYSTTTKGNLSIHMQSDKHLNNMQELQNGGAPNQEARQASPKAPPLHHSPVSSGHKPKPSFRCDVCNYETNVARNLRIHMTSEKHTHNMLVLQQNVKHMQTLSALHHQQHPQQHMESLYGMYPGLGDKPEAALADMAYNQALLIQMMTGGQIPGHGGPADMSAHSDLGLNPETMEPPPEPADPDPDKIFQCCVCNVFQTDSLEELGRHLALDRTRLREQEILAVVAGHYVCKLCTYKTNLKANFQLHCKTDKHLQRLQHVNHVKEGGPRNEWKLKYASAPGGVQIRCNACDYYTNSAHKLQLHAAAGRHDAGVALLKHLLERCSTLSPNQARVFHCSLCGFSSTNRLPLLQHVRSLKHLHMEQLHQLQRRAEGKDNSPEIGEVFHVVPAPIEHQQQHQPHQMTQERRDSVNSEQSQHDSTRDQVKSEPREELEEQPSSEGGSQQHMCPFCEYSSDSEMRIQAHILAQHGTNNAPPSQEQPLLHCPLCQDAFKDRTSLERHVMQIHSVNSEGLQRLLMLVDQSHWLNQSSRTPTPNNSMQVQQTVSPTSVSSKESNRFEKSDPSHQDTEPDLLSPTSDDNPEESERCGTCYKTFRNIDELCYHQNETGHLEIKQTPSGPGYVCWKKGCNQFFPTAHTLQMHFKEVHAKNSIANMSVSEKHVYKYRCNQCSLAFKTLEKLQLHSQYHMIRDATKCVLCGRSFRSLVALHKHVESVHSELTDEELNAYKTSLMNNPLLLAGLQGQVLDSSTNEILKKESLRSEEESGECDDSKELSTSQSLDDSNQNDGDNSDDSIIYKDQQFLEDYLNSQAIAEDSYNDPNRKYKCHRCKVAFTRQSYLTAHNKTLLHRKGEKLSYPMEKYLDPNRPYKCDVCKESFTQKNILLVHYNSVSHLHKLKRAMQEQQNNNNNPPISPITGGTQPQNLTLTPKSTSSEEDDKKKYRCNICKVAYTQGSTLDIHMRSVLHQTRASKLQDLAMAGQIDLTKPLIEQPDAMQSPKQPSPTPGSGDKQPSPTTPPSPGLSGSQQQPQGMMSLSCPKCGAQFTSQDQLNAHQQLYCMFASPMAIFQGVPEPGQAKSPPPGGTEQDAAAAIRLNLPKKTGSHMYKHLLESFGFDLVMQYNETHQRRQRQQREAEEKAASEANTPPPPKEEEPAAIVEAAPAATECELTDNKQTTEEDVTDSDLPEVSKSTCQHCNKEFSSVWVLKSHCEEVHKDLVPLEFLEKYAQQFKNEYEKKTVVVTAATSSTVNTTPRSTTPGGSTPTTTAVPTSTSPVENTPTPEKEDESKEQLHQKLNIPPEAPSTPTSSTTPASSTDSLPANIQAMIAQSMAQNPMALAQQMSEMQAALNVMQLQQLNFSPMMQMMGMGLPLGLNALAAMNLQPPLVPLMMPPPPYDPMSQFGPQDQQALLAKQQQAMMQQQAAVNAAANQKRARTRITDDQLKILRAHFDINNSPSEEQIHEMASQSGLPPKVIKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYEKTGEAKVMPLNSSGSSSDEHKPTKDSPHQSHNEIKTEMKEEPVEEQPPPKYEEKQQECNEEKPNIFNLPLNLQPPQSPVTSIASSDNQSVSQPSTPNNLTLTSIIASQLGDTITTSTPTMNMTNMSTHHGLTSPMLPPPKLNQQNFPNPNNMQGMLPLTPNRCLSPSREYSNPGSNSGSTGKRANRTRFTDYQIKVLQEFFENNAYPKDDDLEYLSKLLSLSPRVIVVWFQNARQKARKVYENQPAADPVPGIPDESGANRFQRTPGLNYQCKKCLLVFQRYYELIRHQKTHCFKEEDAKRSAQAQAAAAQIAAVLSSEDSNSSTTVEQQQHQAPPQPLQLPPQAGVQQQQQQPVQQNPAHSPSSQPNPSTTPTPSQSQSSFAPTSPSPSETKEGTFQCDKCNLVFPRFELWREHQLVHLMNPNLFPPSYPPDSPFGILQQHAQLQQLNSNLDLSKPQNNAPQQNIPHPLINMLNNVTGQKRKVEEFEGESDTSDQPKDKRLRTTILPEQLDYLYQKYQIESNPSRKMLENIAREVGLKKRWCRYGSKTLEPEREKGNSELMLK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00260867;
90% Identity: iTF_00260867; iTF_00249199; iTF_00248752;
80% Identity: iTF_00260867;