Basic Information

Gene Symbol
-
Assembly
GCA_942486075.2
Location
CALNXM020000744.1:130383-132160[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.0018 0.087 13.5 0.6 2 20 256 274 255 278 0.88
2 10 0.99 48 4.9 3.8 6 23 288 305 288 305 0.98
3 10 9.4e-07 4.6e-05 23.8 2.5 1 23 311 334 311 334 0.97
4 10 4.3e-06 0.00021 21.8 1.9 1 23 343 365 343 365 0.98
5 10 0.031 1.5 9.6 0.9 1 23 371 394 371 394 0.88
6 10 0.0023 0.11 13.2 0.4 3 23 400 420 399 420 0.96
7 10 0.085 4.2 8.2 3.1 2 23 429 451 428 452 0.93
8 10 0.00035 0.017 15.8 0.1 1 23 458 481 458 481 0.96
9 10 1.8e-05 0.00088 19.8 0.5 1 23 487 509 487 509 0.99
10 10 5.3e-05 0.0026 18.3 8.3 1 23 515 538 515 538 0.98

Sequence Information

Coding Sequence
ATGTCTTTGGCTACATTATGTCGATTATGTGTGTGCCCTTTCCACGATTGCAAGCAATTATTTGATGAAAACGGTCAGTGCAATGATGCCTATGATATAGCCACCAAATATTTTGACCCAATGTTATTAAATTCCGAACAAGAATTGAACTCACCAGTTATATGTGCAGAATGTTGGCAGCATATCAGTGACTTTTATAATTTCCAACAGTCTGTGTATACGGCACAATCCAAGTTGGAAGATGTTAAGCAAATTGTACCAATTATTAAACTAGAGGAAGAACTAATAGACGAAACAGCTATAGCAAACAGTGACCCACAAAGCGATGCTTTATTGAATGATGAACTTAAAGATGAAGAGCACATATCCGATGTAGATACGTTCGATATACGAGACGACAATCCCTTCAGTTCAGATGATGAGAGACCCCTATTAGAAAGTATAAAGAAAGTTACCAGGAAGAAGACAGCTTCGAAGAGAAGTGCTAATAAAAAGGATGCATCTGGAGAAAGCACAGAAAAGGCTAAAACGCCACCAAAGAAAAAAGAAAAACGTATTAAAAAAGGCACCAAAAGCAAAACAAAGGCAAAAGCTACTGATAATGAAATAAAGGCAGAAGCGTCTGAAGATCCCAATGATTCAGCTAATAATAATGAACAAAGTGGCAGTCAAAATGAAAACGCCTCATCCAGCGACAAAATTAGTTACAATAAACAAAGAACTTTGGAGAATGATGCGTATATAGCTGCCTGGCGTAGTGAGTTGGAATGTGAAATTTGTCATGCCGCATTTTCAAACTATACTTTGTTACGTAAACATTTTGTGCAAGAACATCCGGGAGAAAAATTCTATGTACTATGTTGTCAACGGAAATTTACCCATCGTTTTCATATAGTAGAACACATACGCCTACATATGGATCCCAATGCCTTTAAATGTGAAATATGTGGTCGTTGTAGTACCAACAGCAGAAACTTAACTAAACATATACGAGAATTACACACTGAAGAGGGAAAACTACGTCCCTTCGAGTGTACAGTCTGTCACAAGTCTTTCATAAACAAGACAGTATTAAGAATTCACATGGAAACGCATGAAACGAATCTTACCCACATATGTAAGGAGTGCGGCAAAGGATTTCCCTCCGAGCAAAGGCGAAATCTACACGAAAAATCAGTGCACAATGCTGATCGAATTTGCGATCAGTGCGGCAAGACATTGCATGGCCCATATGCTCTCAAGAAGCATCTACTGGAACATGCTGGCGTGCAAAAGCGTAAATGGCCCTGTGACCAATGTGGTGCCGAATTGCACTCACATTCTAGTTTAAAAAGACACAAACTCATTACACATCACGATGGTTCCACAGTGTATGTATGCAGTGAGTGTGGCAAAGTTGCCACTACGGAAATGGCATTACGTAGTCACAAGAAGAATGTTCATCAAACTGAGCGCAAATTCAAATGTACAATATGTGAGAAAAGCTTTAAGTTTGCAATAGTGCTACGCgaacatatggctacgcatacaggcgaagatctctaccaatgtccacattgcacgaaaacattcaaaaccaatgccaatatgcaccatcatcgtaagaaggcacatcctaaagagtgggcagaggctcgtatgaataaaCCACAATCGACAAAAGTTGATTTCAATCTGGTACAAAATGAAGTCGTTATATAG
Protein Sequence
MSLATLCRLCVCPFHDCKQLFDENGQCNDAYDIATKYFDPMLLNSEQELNSPVICAECWQHISDFYNFQQSVYTAQSKLEDVKQIVPIIKLEEELIDETAIANSDPQSDALLNDELKDEEHISDVDTFDIRDDNPFSSDDERPLLESIKKVTRKKTASKRSANKKDASGESTEKAKTPPKKKEKRIKKGTKSKTKAKATDNEIKAEASEDPNDSANNNEQSGSQNENASSSDKISYNKQRTLENDAYIAAWRSELECEICHAAFSNYTLLRKHFVQEHPGEKFYVLCCQRKFTHRFHIVEHIRLHMDPNAFKCEICGRCSTNSRNLTKHIRELHTEEGKLRPFECTVCHKSFINKTVLRIHMETHETNLTHICKECGKGFPSEQRRNLHEKSVHNADRICDQCGKTLHGPYALKKHLLEHAGVQKRKWPCDQCGAELHSHSSLKRHKLITHHDGSTVYVCSECGKVATTEMALRSHKKNVHQTERKFKCTICEKSFKFAIVLREHMATHTGEDLYQCPHCTKTFKTNANMHHHRKKAHPKEWAEARMNKPQSTKVDFNLVQNEVVI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00435903;
90% Identity
iTF_00200179;
80% Identity
-